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Genome Integrity Discussion Group October 2010


for Members

Genome Integrity Discussion Group October 2010

Monday, October 4, 2010

The New York Academy of Sciences

Presented By


The greater New York Metropolitan area has become a leading center for research on chromosome biology and function, as well as for research at the interface between chromosome integrity and onset and progression of malignancy. The connection between cancer and genome integrity is widely appreciated, and the concentration of excellence in this field is unparalleled anywhere in the world. The Genome Integrity meetings are designed to provide a forum for interactions between the many basic science and clinically-oriented research groups working on these issues. We feel that these interactions will not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities will be revealed.

In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions.

The Genome Integrity Meetings are organized under the leadership of John Petrini, PhD (Memorial Sloan-Kettering Cancer Center), and Rodney Rothstein, PhD and Lorraine Symington, PhD (Columbia University). Meetings include a scientific symposium from 2:00 to 5:30 PM, followed by a networking reception from 5:30 to 6:30 PM.


*Presentation times are subject to change.

2:00 PM

Mechanism and Regulation of Meiotic Recombination Initiation
Scott Keeney, PhD, Memorial Sloan-Kettering Cancer Center

2:30 PM

Physiological Sources of DNA Lesions and Hierarchy of Repair During Quiescence
Benoít Arcangioli, PhD, Institut Pasteur

3:00 PM

RNase H2 and Genome Stability
Hannah Klein, PhD, NYU School of Medicine

3:30 PM

Microtubule-Depolymerizing Kinesin Klp10A is Required for Meiotic Spindle Integrity in Drosophila Females
Sarah J. Radford, Rutgers University (McKim lab, Waksman Institute)

3:45 PM

Coffee Break

4:15 PM

The Interplay Between Mre11 and Ku in the Repair of CPT-induced DNA Damage
Steven S. Foster, Memorial Sloan-Kettering Cancer Center (Petrini lab)

4:30 PM

The Regulation of DNA Deamination During Generation of Antibody Diversity
Uttiya Basu, PhD, Columbia University Medical Center

5:00 PM

ATP-independent DNA Strand Exchange by RecQ Family DNA Helicases
Steve Brill, PhD, Rutgers University

5:30 PM

Networking Reception



John Petrini, PhD

Memorial Sloan-Kettering Cancer Center

Rodney Rothstein, PhD

Columbia University Medical Center

Lorraine Symington, PhD

Columbia University Medical Center


Benoît Arcangioli, PhD

Institut Pasteur

Uttiya Basu, PhD

Columbia University Medical Center

Steve Brill, PhD

Rutgers University

Steven S. Foster

Memorial Sloan-Kettering Cancer Center

Scott Keeney, PhD

Memorial Sloan-Kettering Cancer Center

Hannah Klein, PhD

NYU School of Medicine

Sarah J. Radford

Rutgers University


For sponsorship opportunities please contact Cristine Barreto at or 212.298.8652.

Presented by

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