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Genome Integrity Discussion Group December 2010


for Members

Genome Integrity Discussion Group December 2010

Monday, December 6, 2010

The New York Academy of Sciences

Presented By


The greater New York Metropolitan area has become a leading center for research on chromosome biology and function, as well as for research at the interface between chromosome integrity and onset and progression of malignancy. The connection between cancer and genome integrity is widely appreciated, and the concentration of excellence in this field is unparalleled anywhere in the world. The Genome Integrity meetings will provide a forum for interactions between the many basic science and clinically-oriented research groups working on these issues. We feel that these interactions will not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities will be revealed.

In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions.

The Genome Integrity Meetings are organized under the leadership of John Petrini (Memorial Sloan Kettering Cancer Center), and Rodney Rothstein and Lorraine Symington (Columbia University). Meetings include a scientific symposium from 2:00 to 5:30 PM, followed by a networking reception from 5:30 to 6:30 PM.


*Presentation times are subject to change.

1:30 PM


2:00 PM

Breaking PAR: Recombination in the XY Chromosome Pair
Maria Jasin, PhD, Memorial Sloan-Kettering Cancer Center

2:30 PM

Transcription Termination and Genome Integrity
Max Gottesman, MD, PhD, Columbia University Medical Center

3:00 PM

Phosphorylation and the Regulation of Meiotic Recombination
Nancy Hollingsworth, PhD, SUNY Stony Brook

3:30 PM

Histone Methylation Directed Bypass of the Mitotic Checkpoint
Peter Thorpe, PhD (Rothstein lab, Columbia University Medical Center)

3:45 PM

Coffee Break

4:15 PM

piRNA-mediated Adaptation to a New Transposon Infection in Drosophila within a Single Generation
Jaspreet Khurana (Theurkauf lab, University of Massachusetts Medical School)

4:30 PM

Structure and Function in the SUMO Pathway
Chris Lima, PhD, Memorial Sloan-Kettering Cancer Center

5:00 PM

How Telomeres Solve the End-protection Problem
Titia de Lange, PhD, The Rockefeller University

5:30 PM

Networking Reception



John Petrini, PhD

Memorial Sloan Kettering Cancer Center

Rodney Rothstein, PhD

Columbia University Medical Center

Lorraine Symington, PhD

Columbia University Medical Center


Titia de Lange, PhD

The Rockefeller University

Max Gottesman, MD, PhD

Columbia University Medical Center

Nancy Hollingsworth, PhD

SUNY Stony Brook

Maria Jasin, PhD

Memorial Sloan-Kettering Cancer Center

Jaspreet Khurana

Theurkauf lab, University of Massachusetts Medical School

Chris Lima, PhD

Memorial Sloan-Kettering Cancer Center

Peter Thorpe, PhD

Rothstein lab, Columbia University Medical Center


For sponsorship opportunities please contact Cristine Barreto at or 212.298.8652.

Presented by

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