Herbert Irving Comprehensive Cancer Center Annual Symposium
Wednesday, May 12, 2010
The progression of a cell from normal to malignant is a multi-step process involving a series of events within the cellular and tissue microenvironment. These ultimately result in dysregulation of key physiological processes, such as proliferation, apoptosis, differentiation, and migration leading to oncogenesis. With the abundance of high throughput technologies allowing for whole genome analysis, it has become increasingly clear that identification of individual oncogenes and tumor suppressors provides only a partial view of the complex, multivariate processes necessary for oncogenesis, tumor progression, and tumor maintenance. The goal of cancer systems biology is therefore to dissect the full complement of molecular interactions that are dysregulated in cancer and to interrogate it to elucidate the underlying pathological mechanisms, their behavior following therapeutic intervention, and their use as diagnostic and prognostic biomarkers.
This day long symposium at the Columbia University Medical Campus will bring together several prominent researchers using systems biology approaches, both computational and experimental, to dissect and interrogate the regulatory networks underlying multiple cancers, to model their perturbations, and to identify novel candidate targets for diagnostic and therapeutic intervention.
This Symposium is not taking place at NYAS. It will be held at the Columbia University, Alumni Auditorium, College of Physicians and Surgeons, 650 West 168th St.
Andrea Califano, Columbia University Medical Center
Discovering Master Regulators and Integrators of tumor-related phenotypes
James R. Downing, St. Jude Children's Research Hospital
The Molecular Pathology of Pediatric Leukemia
Joe W. Gray. Lawrence Berkeley National Laboratory/UCSF
Therapeutic insights in breast cancer from a preclinical systems biology approach
Antonio Iavarone, Columbia University Medical Center
Master regulators of development and cancer in the brain
Douglas A. Lauffenburger, Massachusetts Institute of Technology
Computational Modeling of Cell Signaling Network Logic
Arnold J. Levine, Institute for Advanced Study/CINJ at UMDNJ-RWJMS
The evolution of the P53 Family of Genes: Structure and Functions
Leona D. Samson, Massachusetts Institute of Technology
Complex Response to Damaging Agents
Chris Sander, Memorial Sloan-Kettering Cancer Center
Systems Biology of Cancer Pathways
Marc Vidal, Dana Farber Cancer Institute/Harvard Medical School