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Herbert Irving Comprehensive Cancer Center Annual Symposium

Herbert Irving Comprehensive Cancer Center Annual Symposium

Wednesday, May 12, 2010

Herbert Irving Comprehensive Cancer Center, Alumni Auditorium, College of Physicians and Surgeons, 650 West 168th St

Presented By

Presented by the Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York Presbyterian Hospital, the Systems Biology Discussion Group, and the Cancer & Signaling Discussion Group


The progression of a cell from normal to malignant is a multi-step process involving a series of events within the cellular and tissue microenvironment. These ultimately result in dysregulation of key physiological processes, such as proliferation, apoptosis, differentiation, and migration leading to oncogenesis. With the abundance of high throughput technologies allowing for whole genome analysis, it has become increasingly clear that identification of individual oncogenes and tumor suppressors provides only a partial view of the complex, multivariate processes necessary for oncogenesis, tumor progression, and tumor maintenance. The goal of cancer systems biology is therefore to dissect the full complement of molecular interactions that are dysregulated in cancer and to interrogate it to elucidate the underlying pathological mechanisms, their behavior following therapeutic intervention, and their use as diagnostic and prognostic biomarkers.

This day long symposium at the Columbia University Medical Campus will bring together several prominent researchers using systems biology approaches, both computational and experimental, to dissect and interrogate the regulatory networks underlying multiple cancers, to model their perturbations, and to identify novel candidate targets for diagnostic and therapeutic intervention.

Please note:

This Symposium is not taking place at NYAS. It will be held at the Columbia University, Alumni Auditorium, College of Physicians and Surgeons, 650 West 168th St.


Andrea Califano, Columbia University Medical Center

Discovering Master Regulators and Integrators of tumor-related phenotypes

James R. Downing, St. Jude Children's Research Hospital

The Molecular Pathology of Pediatric Leukemia

Joe W. Gray. Lawrence Berkeley National Laboratory/UCSF

Therapeutic insights in breast cancer from a preclinical systems biology approach

Antonio Iavarone, Columbia University Medical Center

Master regulators of development and cancer in the brain

Douglas A. Lauffenburger, Massachusetts Institute of Technology

Computational Modeling of Cell Signaling Network Logic

Arnold J. Levine, Institute for Advanced Study/CINJ at UMDNJ-RWJMS

The evolution of the P53 Family of Genes: Structure and Functions

Leona D. Samson, Massachusetts Institute of Technology

Complex Response to Damaging Agents

Chris Sander, Memorial Sloan-Kettering Cancer Center

Systems Biology of Cancer Pathways

Marc Vidal, Dana Farber Cancer Institute/Harvard Medical School

Interactome Networks