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Genome Integrity Discussion Group April 2011


for Members

Genome Integrity Discussion Group April 2011

Monday, April 4, 2011

The New York Academy of Sciences

Presented By


The greater New York Metropolitan area has become a leading center for research on chromosome biology and function, as well as for research at the interface between chromosome integrity and onset and progression of malignancy. The connection between cancer and genome integrity is widely appreciated, and the concentration of excellence in this field is unparalleled anywhere in the world. The Genome Integrity meetings are designed to provide a forum for interactions between the many basic science and clinically-oriented research groups working on these issues. We feel that these interactions will not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities will be revealed.

In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions.

The Genome Integrity Meetings are organized under the leadership of John Petrini (Memorial Sloan Kettering Cancer Center), and Rodney Rothstein and Lorraine Symington (Columbia University). The April 2011 meeting includes a scientific symposium from 2:00 to 5:15 PM, followed by a networking reception from 5:15 to 6:00 PM.

Networking reception to follow.


*Presentation times are subject to change.

2:00 PM

Understanding the Complexity of the Human RECQ Helicases in Genome Maintenance
Yilun Liu, PhD, Yale University

2:30 PM

XLF Has Overlapping Functions with ATM and Its Substrates during V(D)J Recombination and DNA Repair
Shan Zha, MD, PhD, Columbia University Medical Center

3:00 PM

The Pif1 Helicase, More Than an Inhibitor of Telomerase, Promotes Genome Stability at G4 Motifs
Ginger Zakian, PhD, Princeton University

3:30 PM

ATM Modulates RAG-mediated Monoallelic Looping of the 3’ End of the Tcra Locus to Control Accessibility and Cleavage
Julie Chaumeil (Skok lab, NYU Medical Center)

3:45 PM

Coffee Break

4:00 PM

Function and Formation of a Nucleosome-depleted Region
Lucy Bai (Siggia & Cross labs, Rockefeller University)

4:15 PM

Genetic Analysis of the DNA Damage Response
John Petrini, PhD, Memorial Sloan-Kettering Cancer Center

4:45 PM

Aberrant Base Excision Repair and Cancer
Joann Sweasy, PhD, Yale University

5:15 PM

Networking Reception



John Petrini, PhD

Memorial Sloan-Kettering Cancer Center

Rodney Rothstein, PhD

Columbia University Medical Center

Lorraine Symington, PhD

Columbia University Medical Center


Yilun Liu, PhD

Yale University

John Petrini, PhD

Memorial Sloan-Kettering Cancer Center

Joann Sweasy, PhD

Yale University

Ginger Zakian, PhD

Princeton University

Shan Zha, MD, PhD

Columbia University Medical Center


For sponsorship opportunities please contact Carmen McCaffery at or 212.298.8642.

Presented by

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