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Genome Integrity Discussion Group December 2011


for Members

Genome Integrity Discussion Group December 2011

Monday, December 5, 2011

The New York Academy of Sciences

Presented By


The greater New York Metropolitan area has become a leading center for research on chromosome biology and function, as well as for research at the interface between chromosome integrity and onset and progression of malignancy. The connection between cancer and genome integrity is widely appreciated, and the concentration of excellence in this field is unparalleled anywhere in the world. The Genome Integrity meetings are designed to provide a forum for interactions between the many basic science and clinically-oriented research groups working on these issues. We feel that these interactions will not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities will be revealed.

In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions.

The Genome Integrity Meetings are organized under the leadership of John Petrini (Memorial Sloan Kettering Cancer Center), and Rodney Rothstein and Lorraine Symington (Columbia University).

This meeting will include a scientific symposium from 2:00 to 5:30 PM, followed by a networking reception from 5:30 to 6:30 PM.

Registration Pricing

Student / Postdoc / Fellow Member:$0
Student / Postdoc / Fellow Nonmember:$15


* Presentation times are subject to change.

Monday, December 5, 2011

2:00 PM

RPA Directs Resection Polarity During Double-strand Strand Break Repair
Lorraine Symington, PhD, Columbia University Medical Center

2:30 PM

Regulation of Initiation of DSB Repair
Jean Gautier, PhD, DrSc, Columbia University

3:00 PM

The Rad 1 Paralogs and Their Place in the BRCA1-BRCA2 Pathway of Homologous Recombination
Simon Powell, MD, PhD, Memorial Sloan-Kettering Cancer Center

3:30 PM

Mechanical Forces Inherent in DNA Replication Loops Regulate Lagging Strand Polymerase Processivity
Isabel Kurth, PhD, The Rockefeller University

3:45 PM

Coffee Break

4:15 PM

Piwi-interacting RNAs Protect DNA Against Loss During Oxytricha Genome Rearrangement
Wenwen Fang, Princeton University

4:30 PM

5-Hydroxymethylcytosine: A Novel Epigenetic Mark?
Mamta Tahiliani, PhD, New York University

5:00 PM

Genomes in Conflict: Maintaining DNA Integrity During Virus Infection
Matthew Weitzman, PhD, University of Pennsylvania

5:30 PM

Networking Reception



John Petrini, PhD

Memorial Sloan-Kettering Cancer Center

Rodney Rothstein, PhD

Columbia University Medical Center

Lorraine Symington, PhD

Columbia University Medical Center


Wenwen Fang

Princeton University

Jean Gautier, PhD, DrSc

Columbia University Medical Center

Isabel Kurth, PhD

The Rockefeller University

Simon Powell, MD, PhD

Memorial Sloan-Kettering Cancer Center

Lorraine Symington, PhD

Columbia University Medical Center

Mamta Tahiliani, PhD

New York University

Matthew Weitzman, PhD

University of Pennsylvania


For sponsorship opportunities please contact Carmen McCaffery at or 212.298.8642.

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