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Dynamics of Immune Cell Communication Networks
Thursday, October 11, 2012
The mission of the immune system is essentially "don't let in any intruders!" In the face of the number of self-molecular epitopes a human produces, and of the even larger number of non-self-antigens it encounters, this mission is easier stated than accomplished.
In terms of fitness, an immune system that triggers a full-blown response upon exposure to any non-self-antigen would be an evolutionary dead-end given its unsustainable energy cost. Humans have inherited a sophisticated system that operates well most of the time: intruders are kept at bay while innocuous visitors from the surrounding ecosystem (such as reproductive vectors from flowering plants) are appropriately disposed of without triggering a response. However, in some instances, the immune system fails, and can be deceived by confounding events. These glitches are to be blamed for autoimmune ailments, ineffective immunotherapies and adverse reactions to biologic-based therapies.
Qualitative narratives of the immune response do not account for the inter-individual variability with regards to autoimmune risk, lack of response to vaccination therapies and adverse response to a therapeutic antibody. This symposium will examine the behavior of the complex, dynamic network with interacting elements including leukocytes, cytokines, and chemokines, with an eye to defining an adequate or inadequate immune response.
*Reception to follow.
Registration Pricing
Member | $0 |
Student/Postdoc Member | $0 |
Nonmember | $40 |
Nonmember (Student / Postdoc / Resident / Fellow) | $20 |
The Systems Biology Discussion Group is proudly supported by
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Agenda
* Presentation times are subject to change.
Thursday, October 11, 2012 | |
6:00 PM | Welcome and Introduction |
6:15 PM | Finding Genes and Networks of the Immune System |
7:00 PM | Emergence of Scaling Properties in Cytokine Communication |
7:45 PM | Pharmacologic Targeting the Immune System: Challenges for Predicting Drug Safety in Humans |
8:30 PM | Networking Reception |
9:30 PM | Close |
Speakers
Organizers
Manuel X. Duval, PhD
Enumeral Biomedical Corp.
Manuel Duval is a bioinformatics scientist doing computational biology research for Drug Discovery and Development. His interest is in characterizing the mode of action of candidate therapeutics agents to cellular systems and to identify the source of inter-individual variability in drug response. Graduated from the Université Joseph Fourier, Grenoble France, Manuel is working in the Drug R&D industry since 2001 following genomics and bioinformatics research at Texas A&M University in the fields of agro-genomics. Manuel Duval is currently leading the bioinformatics and computational biology activity at Enumeral Biomedical in Cambridge MA.
Jennifer Henry, PhD
The New York Academy of Sciences
Speakers
Debashis Barik, PhD
Memorial Sloan-Kettering Cancer Center
I am currently a postdoctoral research assistant in the Computational Biology and Immunology program at the Memorial Sloan-Kettering Cancer Center (New York, NY). I am currently working on understating the dynamics of cell-cell communications via cytokines in T lymphocytes using both experiments and mathematical modeling. Before joining MSKCC, I was a post-doctoral research assistant in the Department of Biological Sciences, Virginia Tech, investigating effects of intrinsic molecular fluctuations on cell cycle, cell size and cell size control in budding yeast using mathematical modeling. I received PhD degree in theoretical physical chemistry from Jadavpur University in India. My graduate works involved statistical mechanics of reaction rate theory in condensed phase.
Christine Grimaldi, PhD
Boehringer-Ingelheim
I received a PhD in Pathology at SUNY Stony Brook. I was a postdoctoral fellow in the laboratory of Betty Diamond at the Albert Einstein College of Medicine, where I studied B cells and mouse models of lupus. I held faculty appointments at Columbia University Medical Center and then the Feinstein Institute for Medical Research, where I remain as an Adjunct Assistant Investigator. In 2008 I joined Boehringer Ingelheim Pharmaceuticals Inc. Currently, I am a Senior Principal Scientist in the Nonclinical Drug Safety Department. My roles and responsibilities include developing nonclinical safety strategies for immune-targeted therapies and head of the Immunotoxicology group.
Nir Hacohen, PhD
Massachusetts General Hospital, Broad Institute and Harvard Medical School
Nir Hacohen, PhD is Associate Professor at Massachusetts General Hospital and Harvard Medical School and Senior Associate Member at the Broad Institute. He obtained a PhD in biochemistry from Stanford University, and then was a Whitehead Institute Fellow. His laboratory develops and applies methods to discover genetic and biochemical networks underlying infectious immunity, autoimmunity and tumor immunity. Nir is a founding member of the RNAi Consortium, a public-private partnership that builds lentiviral genome-wide RNA interference libraries to silence every gene of the mouse and human genomes, and a founder of the Broad’s Immune Circuits Initiative. Through these efforts, a community of researchers has employed RNAi technologies to dissect both innate and adaptive immunity processes. Dr. Hacohen’s research has shown that immune cells turn on tailored genetic programs in response to distinct threats, enabling the immune system to distinguish viruses, bacteria, and fungi. He has uncovered key genes underlying the host innate immune response to pathogens, the influenza-host interaction and T cell activation. His current focus is on reconstructing molecular networks of the immune system in mice and humans.
Sponsors
Promotional Partner
The New York Academy of Medicine
The Systems Biology Discussion Group is proudly supported by
Mission Partner support for the Frontiers of Science program provided by 
Abstracts
Finding Genes and Networks of the Immune System
Nir Hacohen, PhD, Massachusetts General Hospital, Broad Institute and Harvard Medical School
Emergence of Scaling Properties in Cytokine Communication
Debashis Barik, PhD, Memorial Sloan-Kettering Cancer Center
Pharmacologic Targeting the Immune System: Challenges for Predicting Drug Safety in Humans
Christine Grimaldi, PhD, Boehringer-Ingelheim
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