
Fetal Programming and Environmental Exposures: Implications for Prenatal Care and Pre-Term Birth
Monday, June 11, 2012 - Tuesday, June 12, 2012
Presented By
Over the past two decades, it has been increasingly recognized that prenatal environmental and pharmaceutical exposures can adversely influence fetal programming, which plays a role in pre-term birth and is linked to lasting adverse health effects and the risk of adult health disorders such as diabetes, high blood pressure, and cardiovascular disease. The New York Academy of Sciences (NYAS) and Cincinnati Children's Hospital Medical Center are jointly presenting a 1.5-day scientific symposium to explore recent discoveries, challenges, and future research directions that further our understanding of the complex environmental and genetic factors, and gene–gene as well as gene–environment interactions responsible for fetal programming in utero and pre-term birth.
This conference will provide a neutral forum for discussion to multidisciplinary science investigators such as toxicologists, obstetricians, neonatologists, pediatricians, endocrinologists, epidemiologists, public health and regulatory experts from basic research to clinical settings, including experts in embryonic, fetal, and childhood development, reproductive medicine and biology, and environmental toxicology. Conference attendees will explore the impact of genetic, epigenetic, and environmental factors on the stages of prenatal development, including pre-implantation, implantation, decidualization, placentation, fetal programming in utero, and links to pre-term birth and other pregnancy disorders.
Experts with diverse perspectives will engage in a dialogue about possible ways in which we can better predict, assess, and decrease the effects of environmental and genetic factors that predispose to adverse fetal outcomes and pre-term birth, thus lowering the enormous associated physical, psychological, and economic costs.
Registration Pricing
By 4/20/2012 | After 4/20/2012 | Onsite: 6/11/2012 | |
Member | $200 | $250 | $275 |
Student / Postdoc / Fellow Member | $125 | $175 | $200 |
Nonmember Academic | $250 | $300 | $325 |
Nonmember Corporate | $300 | $350 | $375 |
Nonmember Not for Profit | $250 | $300 | $325 |
Student / Postdoc / Fellow Nonmember | $125 | $175 | $200 |
Presented by
For a full list of sponsors, please view the Sponsors tab.
Agenda
* Presentation times are subject to change.
Day 1 — Monday, June 11, 2012 | |
11:00 AM | Registration & Poster Set-up |
11:00 AM | Meet & Greet Networking Session (concurrent) |
12:00 PM | Opening Remarks |
12:15 PM | Keynote Address |
Session I: Genetic / Epigenetic Programming of Pre-implantation DevelopmentChair: Marco Conti, MD, University of California, San Francisco | |
12:45 PM | Networks of RNA Binding Proteins Regulate Maternal mRNA Translation Essential for Oocyte Maturation and Early Embryo Development |
1:10 PM | Maternal Diabesity, Oocyte Quality and Reproductive Outcomes |
1:35 PM | Trophoblast Cell Subtypes Orchestrating the Development of the Maternal-Fetal Interface |
2:00 PM | Session I Panel and Audience Discussion |
2:20 PM | Networking Break |
Session II: Embryo–Uterine Cross-TalkChair: Adrian Erlebacher, MD, PhD, New York University Langone Medical Center | |
2:50 PM | Paracrine Signals Regulating Embryo Implantation and Uterine Decidualization |
3:15 PM | Nuclear Receptor Regulation of Gestation |
3:40 PM | Immune Surveillance of the Maternal/Fetal Interface: Implications for Fetal Loss and Preterm Birth |
4:05 PM | Session II Panel and Audience Discussion |
Session III: Young Investigator PresentationsChair: Sudhansu K. Dey, PhD, Cincinnati Children's Hospital Medical Center | |
4:25 PM | Asynchronous Peri-Implantation Events Characterize a Mouse Model of Preeclampsia, BPH/5 |
4:40 PM | Heightened Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling Provokes Premature Decidual Senescence and Preterm Birth |
4:55 PM | Extraembryonic Hematopoietic Niches: Cross-Talk between Non-Hematopoietic and Hematopoietic Populations in Human Placenta and Chorion |
5:10 PM | Effects of Bisphenol A Exposure on Genomic Imprinting in Mouse |
5:25 PM | Networking Reception and Poster Session |
7:00 PM | Day 1 Concludes |
Day 2 — Tuesday, June 12, 2012 | |
8:00 AM | Networking Breakfast |
8:00 AM | Young Investigators Career Mentoring Breakfast (concurrent) |
Session IV: Decidualization and PlacentationChair: R. Michael Roberts, PhD, University of Missouri–Columbia | |
8:45 AM | Fate Specification During Human Pre-Implantation Development |
9:10 AM | Regulatory Pathways Controlling Hemochorial Placentation |
9:35 AM | Conversion of Umbilical Cord Mesenchyme to Trophoblast: A Glimpse at the Past |
10:00 AM | Session IV Panel and Audience Discussion |
10:20 AM | Networking Break |
10:50 AM | Keynote Address |
Session V: Genetic and Environmental Influences Affecting Fetal Programming In UteroChair: Sarah F. Leibowitz, PhD, The Rockefeller University | |
11:15 AM | Glucose Tolerance in Adults after Prenatal Exposure to Famine |
11:40 AM | Paternal Influence on Offspring Metabolism |
12:05 PM | Role for Placental Metabolic Pathways in Modulating Fetal Brain Development: Impact of Serotonin |
12:30 PM | Lunchtime Breakout Roundtable Discussions |
Session V: Genetic and Environmental Influences Affecting Fetal Programming In Utero (continued)Chair: Sarah F. Leibowitz, PhD, The Rockefeller University | |
1:30 PM | Mechanisms of Genetic Quality Control in the Germline |
1:55 PM | Maternal High-Fat Diet, Alcohol and Fetal Programming |
2:20 PM | Session V Panel and Audience Discussion |
2:50 PM | Networking Break |
Session VI: Pregnancy Disorders and Prematurity: Gene–Environment InteractionsChair: S. Anath Karumanchi, MD, Beth Israel Deaconess Medical Center | |
3:15 PM | Genetics and Genomics of Human Preterm Birth |
3:40 PM | The Rebirth of Progesterone: Cervical Ultrasound and Progesterone to Prevent Preterm Birth |
4:05 PM | Angiogenesis and Preeclampsia: Functional Characterization of Two Novel Secreted Gene Products Of Placental Origin (Sflt1 And Seng) |
Session VII: Environment, Hormone Action, and Pharmacological / Endocrine DisruptorsChair: L. David Wise, PhD, Merck | |
4:30 PM | Disruption of Uterine Cytodifferentation by Developmental Exposures to Diethylstilbrestrol |
4:55 PM | Making Eggs and Sperm: Environmental Effects on Gametogenesis |
5:20 PM | Prenatal Development Toxicity Study Design for Pharmaceucticals |
5:45 PM | Session VI & VII Panel and General Audience Discussion |
6:25 PM | Closing Remarks |
6:30 PM | Conference Concludes |
Speakers
Organizers
Sudhansu K. Dey, PhD
Cincinnati Children's Hospital Medical Center
Susan J. Fisher, PhD
University of California, San Francisco
Jeffrey A. Whitsett, MD
Cincinnati Children's Hospital Medical Center
Keynote Speakers
Randy L. Jirtle, PhD
Duke University
Frederick S. vom Saal, PhD
University of Missouri–Columbia
Speakers
Alicia Bárcena, PhD
University of California, San Francisco
Jeeyeon Cha
Cincinnati Children's Hospital Medical Center
John R. G. Challis, PhD
University of Toronto
Marco Conti, MD
University of California, San Francisco
James Charles Cross, DVM, PhD
University of Calgary
Francesco J. DeMayo, PhD
Baylor College of Medicine
Adrian Erlebacher, MD, PhD
New York University Langone Medical Center
Patricia Hunt, PhD
Washington State University
S. Anath Karumanchi, MD
Beth Israel Deaconess Medical Center
Sarah F. Leibowitz, PhD
The Rockefeller University
Pat R. Levitt, PhD
University of Southern California
Liang Ma, PhD
Washington University
Margaret Ann Miller, PhD
National Center for Toxicological Research, FDA
Kelle H. Moley, MD
Washington University School of Medicine in St. Louis
Louis J. Muglia, MD, PhD
Cincinnati Children's Hospital Medical Center
Bruce Murphy, PhD
Universite de Montreal
Oliver J. Rando, MD, PhD
University of Massachusetts Medical School
R. Michael Roberts, PhD
University of Missouri–Columbia
John M. Rogers, PhD
United States Environmental Protection Agency
Roberto Romero, MD
National Institute of Child Health & Human Development, NIH
John Schimenti, PhD
Cornell University
Thaddeus Schug, PhD
National Institute of Environmental Health Sciences
Michael J. Soares, PhD
Kansas University Medical Center
Jenny Sones, DVM
Cornell University
Martha Susiarjo, PhD
University of Pennsylvania
L. David Wise, PhD
Merck
Sponsors
For sponsorship opportunities please contact Kerstin Hofmeyer, PhD at khofmeyer@nyas.org or 212.298.8610.
Presented by
Academy Friends
Grant Support
Supported in part by March of Dimes Foundation Grant No. 4-FY12-545.
Funding for this conference was made possible (in part) by grant number 1R13ES021699-01 from the National Institute of Environmental Health Sciences (NIEHS) and National Institute on Drug Abuse (NIDA). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Promotional Partners
American College of Medical Genetics and Genomics
The New York Academy of Medicine
Obstetric-Fetal Pharmacology Research Units (OPRU)
Scientific Research Publishing - Open Journal of Obstetrics and Gynecology
Abstracts — Day One
Keynote Address
Challenges for Reproductive Toxicology Posed By Unpredicted Effects on Fetuses Of Very Low-Doses Of Estrogenic Endocrine Disrupting Chemicals
Frederick S. vom Saal, PhD, University of Missouri–Columbia
Session I: Genetic / Epigenetic Programming of Pre-implantation Development
Networks of RNA Binding Proteins Regulate Maternal mRNA Translation Essential for Oocyte Maturation and Early Embryo Development
Marco Conti, MD, University of California, San Francisco
Coauthors: Jing Chen, Matthew Cook, Chih-Jen Lin, Andrej Susor, and Jeong Su Oh, University of California, San Francisco.
Maternal Obesity, Oocyte Quality, and Reproductive Outcomes
Kelle H. Moley, MD, Washington University in St. Louis School of Medicine
One proposed mechanism for compromised oocyte quality and poor reproductive outcomes in obese females includes altered mitochondrial activity at the oocyte stage. Abnormal mitochondria structure and function in oocytes from type 1 diabetic mice are associated with poor fertilization rates and abnormal embryo development. It is apparent that both obesity and diabetes influence mitochondrial activity. In obese mice, uneven mitochondrial distribution and altered mitochondrial DNA copy number are linked to impaired embryonic development from the zygote to blastocyst stage. Diabetic mice have increased abnormalities in mitochondria morphology, distribution, and mtDNA copy number. These mice also exhibit spindle defects/chromosome misalignment; defects associated with mitochondrial metabolism and changes in endocrine surroundings. In the unpublished data presented in this talk, we will show that maternal obesity adversely affects oocyte mitochondria and spindle formation, and that this isolated early preimplantation insult will negatively impact embryo outcomes when transferred into nonobese control recipient mice.
Trophoblast Cell Subtypes Orchestrating the Development of the Maternal–Fetal Interface
James Charles Cross, DVM, PhD, University of Calgary, Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada
Session II: Embryo–Uterine Cross-Talk
Paracrine Signals Regulating Embryo Implantation and Uterine Decidualization
Francesco J. DeMayo, PhD, Baylor College of Medicine, Houston
Specialized Cooperative Centers in Reproduction and Infertility Research, U54HD0077495 (F.J.D.) and NIH Grant RO1-CA77530 and the Susan G. Komen Award BCTR0503763 (J.P.L.)
Coauthor: John P. Lydon, Baylor College of Medicine, Houston.
Nuclear Receptor Regulation of Gestation
Bruce Murphy, PhD, Université de Montréal
Immune Surveillance of the Maternal–Fetal Interface: Implications for Fetal Loss and Preterm Birth
Adrian Erlebacher, New York University School of Medicine and New York University Cancer Institute
Coauthors: Elisa Tagliani, Mary K. Collins, and Patrice Nancy, New York University School of Medicine.
Session III: Young Investigator Presentations
Asynchronous Peri-implantation Events Characterize a Mouse Model of Preeclampsia, bph/5
Jenny Sones, DVM, Cornell University, Ithaca, NY
Coauthors: Yi Zhou, PhD,1 Ashley Woods, PhD,1 Emilie Williamson,1 Ethan Green,1 Catherine Isroff,1 Robin L Davisson, PhD,1,2
1Cornell University, Ithaca, NY
2Weill Cornell Medical College, New York, NY
Heightened Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling Provokes Premature Decidual Senescence and Preterm Birth
Jeeyeon Cha, Division of Reproductive Sciences, Cincinnati Children's Hospital Research Center, Cincinnati, OH, USA
Coauthors: Yasushi Hirota2, Takiko Daikoku1, Sudhansu K. Dey1
1Division of Reproductive Sciences, Cincinnati Children's Hospital Research Center, Cincinnati, OH, USA
2Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
Extraembryonic Hematopoietic Niches: Cross-Talk Between Non-Hematopoietic and Hematopoietic Populations in Human Placenta and Chorion
Alicia Bárcena, PhD, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Center for Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences University of California, San Francisco, San Francisco, CA
Coauthors: Marcus O. Muench, Mirhan Kapidzic, Nicholas Larocque, Susan J. Fisher, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Center for Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences University of California, San Francisco, San Francisco, CA
Effects of Bisphenol a Exposure on Genomic Imprinting in Mouse
Martha Susiarjo, PhD, Center of Excellence in Environmental Toxicology and Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Research supported by University of Pennsylvania Center of Excellence in Environmental Toxicology 2008 Pilot Project Funding P30 ES013508 and NIEHS F32ES019416.
Coauthors: Isaac Sasson, Department of Obstetric and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Clementina Mesaros, Center of Excellence in Environmental Toxicology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Marisa Bartolomei, Center of Excellence in Environmental Toxicology and Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
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Special Needs and Additional Information
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