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Genome Integrity Discussion Group February 2012


for Members

Genome Integrity Discussion Group February 2012

Monday, February 6, 2012

The New York Academy of Sciences

Presented By


The greater New York Metropolitan area has become a leading center for research on chromosome biology and function, as well as for research at the interface between chromosome integrity and onset and progression of malignancy. The connection between cancer and genome integrity is widely appreciated, and the concentration of excellence in this field is unparalleled anywhere in the world. The Genome Integrity meetings are designed to provide a forum for interactions between the many basic science and clinically-oriented research groups working on these issues. We feel that these interactions will not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities will be revealed.

In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions.

Genome Integrity Discussion Group meetings are organized under the leadership of John Petrini (Memorial Sloan Kettering Cancer Center), and Rodney Rothstein and Lorraine Symington (Columbia University).

This meeting will include a scientific symposium from 2:00 to 5:30 PM, followed by a networking reception from 5:30 to 6:30 PM.


John Petrini, PhD

Memorial Sloan-Kettering Cancer Center

Rodney Rothstein, PhD

Columbia University Medical Center

Lorraine Symington, PhD

Columbia University Medical Center


Bruce Demple, PhD

Stony Brook University

Wenxia Jiang, PhD

Columbia University

Megan King, PhD

Yale University

Kim McKim, PhD

Waksman Institute

Nikola Pavletich, PhD

Memorial Sloan-Kettering Cancer Center

Erika Shor, PhD

Princeton University

Stewart Shuman, MD, PhD

Memorial Sloan-Kettering Cancer Center

Registration Pricing

Student / Postdoc / Fellow Member$0
Student / Postdoc / Fellow Nonmember$15


* Presentation times are subject to change.

Monday, February 6, 2012

2:00 PM

New Way of Making Ends Meet
Stewart Shuman, MD, PhD, Memorial Sloan-Kettering Cancer Center

2:30 PM

Repair Systems for Endogenous Lesions in Nuclear and Mitochondrial DNA
Bruce Demple, PhD, Stony Brook University

3:00 PM

A Nuclear Envelope-bridging Complex Influences DNA Repair
Megan King, PhD, Yale University

3:30 PM

53BP1 and XLF Overlapping Function in End Joining and Lymphocyte Development
Wenxia Jiang, PhD, Columbia University

3:45 PM

Coffee Break

4:15 PM

The Environmental Stress Response Regulates Genetic Mutation in Saccharomyces cerevisiae
Erika Shor, PhD, Princeton University

4:30 PM

From Synthetic Lethality to Meiosis: Genetics of Acentrosomal Spindle Assembly in Drosophila
Kim McKim, PhD, Waksman Institute

5:00 PM

Structure and DNA-binding Activity of the Fanconi Anemia FANCI-FANCD2 Complex
Nikola Pavletich, PhD, Memorial Sloan-Kettering Cancer Center

5:30 PM

Networking Reception


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