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Monitoring RNA for Diagnosis and Prognosis: Visualization of RNA in Tissues and Monitoring RNA in Circulation
Monday, April 23, 2012
Monitoring changes in the abundance of protein-coding and non-coding RNAs in tissues is valuable for diagnosis and prognosis of various disease states. RNA in circulation has also received significant interest in biomarker studies. Though the detection and quantification of RNA molecules appears within reach for such applications, technical concerns related to the preservation of RNA in tissues or its abundance and fixation in tissue are just some of the issues that have interfered with the establishment of routine diagnostic and prognostic RNA assays in comparison to protein-detection-based approaches. This symposium will review the current state of RNA methodologies and how these will impact the future development of RNA diagnostics.
Reception to follow.
Registration Pricing
Member | $0 |
Student / Postdoc / Fellow Member | $0 |
Nonmember | $30 |
Nonmember Student | $15 |
Agenda
* Presentation times are subject to change.
Monday April 23, 2012 | |
12:30 PM | Registration |
1:00 PM | Welcome and Introduction |
1:10 PM | A Transgenic Mouse Model for Imaging Single RNA Dynamics in Tissue |
1:45 PM | Development of Quantitative Multiplex RNA in situ Hybridization for Diagnostic Applications |
2:20 PM | RNA Mimics of Green Fluorescent Protein |
2:55 PM | Coffee Break |
3:30 PM | Deep Sequence Profiles of Circulating MicroRNA |
4:05 PM | Massive Expansion of RNA Species in Tissues and in Circulation Revealed from RNA-Sequencing |
4:40 PM | Quantitation of Tissue-Specific Target Gene Modulation using Circulating RNA |
5:15 PM | Networking Reception |
6:00 PM | Close |
Speakers
Organizers
Tom Tuschl, PhD
The Rockefeller University
Dr. Tuschl received his PhD in chemistry from the University of Regensburg, in Germany, in 1995. He went to the Max Planck Institute for Experimental Medicine in Göttingen, Germany, pursuing research with Fritz Eckstein. He next joined the biology department at the Massachusetts Institute of Technology and the Whitehead Institute for Biomedical Research, where he worked with Phillip A. Sharp and David P. Bartel. Dr. Tuschl was a junior investigator at the Max Planck Institute for Biophysical Chemistry before coming to Rockefeller in 2003 as associate professor. He was named professor in 2009. Dr. Tuschl's most recent honors include the Ernst Jung Prize for Medicine in 2008 and the Max Delbrück Medal and the Karl Heinz Beckurtz Award in 2007. In 2006 he received the Molecular Bioanalytics Prize from Roche Diagnostics. In 2005 he was named a fellow of the New York Academy of Sciences and received the Meyenburg Prize, the Irma T. Hirschl Trust Career Scientist Award and the Ernst Schering Award. In 2003 he received the Wiley Prize in Biomedical Sciences, the New York City Mayor's Award for Excellence in Science and Technology and the Newcomb Cleveland Prize from the American Association for the Advancement of Science. Dr. Tuschl was the recipient of the European Molecular Biology Organization Young Investigator Award in 2001 and the Biofuture Award from the German government in 1999. He is also a Howard Hughes Medical Institute investigator.
Jennifer Henry, PhD
The New York Academy of Sciences
Speakers
Pavol Cekan, PhD
The Rockefeller University
Pavol Cekan is a post-doctoral researcher in Thomas Tuschl’s laboratory at the Rockefeller University. Pavol received his B.Sc. and Ph.D. from the University of Iceland. As a PhD candidate, Pavol trained as nucleic acid chemist/biochemist and structural biologist with a focus on modified oligonucleotide synthesis and spectroscopic analysis of nucleic acid structure and function. After joining the Tuschl lab in 2009, he has focused on developing novel processes for improving the retention of nucleic acids in tissue sections during RNA in situ hybridization as well as preparation of specific oligonucleotide probes and fluorescent signal amplification processes. Currently, he is establishing conditions for diagnostic microRNA/mRNA in situ hybridization.
Iddo Ben-Dov, MD, PhD
The Rockefeller University
Iddo Ben-Dov is a post-doctoral researcher in Thomas Tuschl's laboratory at the Rockefeller University. Iddo received his M.Sc., M.D. and Ph.D. from the Hebrew University in Jerusalem. For his Masters degree, he studied piezoelectric microbalance immunosensing of C. trachomatis in clinical specimens with Prof. Itamar Willner. His medical training in internal medicine and nephrology was combined with and followed by molecular biology studies of the parathyroid hormone mRNA in the laboratory of Profs. Tally Naveh and Justin Silver. Since 2009 he is an instructor in clinical investigation at the Rockefeller University's Clinical Scholars program and the Tuschl lab, where he conducts patient-oriented RNA research.
Samie R. Jaffrey, MD, PhD
Weill Medical College of Cornell University
Dr. Samie Jaffrey is an Associate Professor of Pharmacology at the Weill Medical College of Cornell University. He received and M.D. and Ph.D. from Johns Hopkins School of Medicine. Dr. Jaffrey's laboratory focuses on RNA regulatory mechanisms in neurons and how RNA processing pathways control neural circuit formation. A major focus is to identify RNA regulatory pathways that occur within growing axons, and to understand how defects in these pathways lead to neurodevelopmental disorders such as mental retardation and autism. His research uses novel viral, proteomic, microfluidic, and chemical biology approaches to address these questions. His group identified the first mRNAs that are locally translated in axons and are required for axon guidance. His laboratory has also developed a novel class of RNAs referred to RNA mimics of green fluorescent protein, which are used to image RNA localization and monitor RNA processing in living cells. The Jaffrey laboratory extended this technology to create a new type of genetically encoded biosensor composed of RNA that allows signaling molecules to be imaged in living cells. Dr. Jaffrey is a Klingenstein Neuroscience Fellow, Irma T. Hirschl Scholar, and recipient of the McKnight Technology development award and the NIH Director's Transformative R01 award.
Christopher E. Mason, PhD
Weill Medical College of Cornell University
Christopher E. Mason is an Assistant Professor of Computational Genomics at Weill Cornell Medical College of Cornell University in New York City, in the Department of Physiology and Biophysics and at the Institute for Computational Biomedicine. He also holds an appointment in the Tri-Institutional Program on Computational Biology and Medicine (Cornell, Memorial Sloan-Kettering Cancer Center and Rockefeller University) and the Weill Cornell Cancer Center. Professor Mason is also an affiliate fellow of Genomics, Ethics, and Law at Yale Law School, where he teaches classes and lectures on the implications of new genomics technology on the law. He has also serves as scientific adviser to the American Civil Liberties Union, faculty adviser the GenSpace community laboratory in Brooklyn, and is also the co-founder of the New York Synthetic Biology Association. Dr. Mason received his dual B.S. in Genetics and Biochemistry from University of Wisconsin-Madison in 2001, his Ph.D. in Genetics from Yale University in 2006, and spent three years as post-doc working at Yale University, focusing on mutations in genes implicated in patients with brain malformations and psychiatric disorders. Dr. Mason's current research focuses on using functional genomics and integrative molecular approaches to understand the genetic architecture of the human brain, and how the genome's elements change in human diseases such as neural tube defects and cancer.
Hye Yoon Park, PhD
Albert Einstein College of Medicine
Dr. Hye Yoon Park is a research fellow in Prof. Robert H. Singer's laboratory at Albert Einstein College of Medicine. Dr. Park received her B.S. in Physics from Seoul National University and her M.S. and Ph.D. in Applied Physics from Cornell University. For her M.S. degree, she performed research on the fabrication processes for polymeric microfluidic devices in Prof. Harold G. Craighead's group. During her Ph.D. research under the guidance of Prof. Lois Pollack and Prof. Watt W. Webb, she developed a laminar flow mixer for kinetic studies of protein and RNA folding on a microsecond time scale. In 2008, she joined the Singer lab as an NIH Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral fellow, and has been working on single molecule imaging of RNA in live cells and tissues.
Alfica Sehgal, PhD
Alnylam
Alfica Sehgal is a Principal Scientist at Alnylam Pharmaceuticals. She has worked on different delivery projects since 2008 and is currently working on siRNA mediated therapeutics for fibrosis and hemophilia. She studied regulation of sterol and oxygen homeostasis during her post-doc at Johns Hopkins and Yale Univ. Her PhD was from Dept of Molecular Biology, TIFR, Mumbai and Masters in molecular biology and BS in microbiology from Delhi University.
Abstracts
Development of quantitative multiplex RNA in situ hybridization for diagnostic applications
Pavol Cekan, PhD, The Rockefeller University
Deep Sequence Profiles of Circulating MicroRNA
Iddo Ben-Dov, MD, PhD, The Rockefeller University
RNA Mimics of Green Fluorescent Protein
Samie R. Jaffrey, MD, PhD, Weill Medical College of Cornell University
Massive Expansion of RNA Species in Tissues and in Circulation Revealed from RNA-Sequencing
Christopher E. Mason, PhD, Weill Medical College of Cornell University
A Transgenic Mouse Model for Imaging Single RNA Dynamics in Tissue
Hye Yoon Park, PhD, Albert Einstein College of Medicine
Quantitation of tissue-specific target gene modulation using circulating RNA
Alfica Sehgal, Alnylam Pharmaceuticals, Inc., Cambridge, MA, USA
*Additional abstracts to come.
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