
Vitamin D: Beyond Bone
Friday, September 21, 2012
Presented By
Over the past decade, researchers have produced data strongly suggesting that vitamin D and its metabolites contribute to a host of biological processes beyond the control of calcium and bone metabolism. This hypothesis is supported by the fact that the vitamin D receptor is expressed on a variety of cell types including lymphocytes, colonic cells, hepatocytes, and myocytes, including cardiac myocytes.
This 1-day conference will explore recent epidemiological data and the molecular mechanisms of action known to underlie the effects of vitamin D on pregnancy, lactation, and immune, metabolic, muscle, and cardiovascular function. Participants will also explore recent changes to vitamin D dietary guidelines, as well as critical next steps in vitamin D research that will aid the translation of basic research and epidemiological data into public health strategies that support the health and well-being of infants, adults, and the aging population.
Registration Pricing
By 9/7/2012 | After 9/7/2012 | Onsite | |
Member | $45 | $70 | $95 |
Student/Postdoc Member | $15 | $40 | $65 |
Nonmember (Academia) | $65 | $90 | $115 |
Nonmember (Corporate) | $85 | $110 | $135 |
Nonmember (Non-profit) | $65 | $90 | $115 |
Nonmember (Student / Postdoc / Fellow) | $30 | $55 | $80 |
Presented by
This event is sponsored by an unrestricted educational grant from Abbott Nutrition Health Institute.
Agenda
* Presentation times are subject to change.
September 21, 2012 | |
8:00 AM | Breakfast and Registration |
9:00 AM | Opening RemarksMandana Arabi, MD, PhD Amanda Ullman, PhD Rosemary E. Riley, PhD, LD |
Session I: Non-Classical Effects of Vitamin DChair: Martin Hewison, PhD, University of California Los Angeles | |
9:30 AM | Vitamin D Biology Beyond Bone |
10:00 AM | Vitamin D in Immune Function and Disease Prevention |
10:30 AM | Networking Coffee Break |
11:00 AM | Role of the Vitamin D Receptor in the Cardiovascular System |
11:30 AM | Vitamin D during Pregnancy and Lactation: Emerging Concepts |
Session II: Early Career Investigator PresentationsChair: Carol L. Wagner, MD, Medical University of South Carolina | |
12:00 PM | The Role of Vitamin D in the Regulation of Apoptotic Signaling Pathways in Obesity |
12:15 PM | Plasma Vitamin D is Independently Associated with Lung Function in Patients with Chronic Obstructive Pulmonary Disease (COPD) |
12:30 PM | Impact of Cholecalciferol Repletion on Erythropoietin Requirements in Vitamin D-deficient Hemodialysis Patients: Pilot Data from a Randomized Controlled Trial |
12:45 PM | Networking Lunch |
Session III: Translating Epidemiological Data into Policy and Clinical Applications in Adult and Aging PopulationsChair: Hawley K. Linke, PhD, Abbott Nutrition | |
2:00 PM | Vitamin D for Type 2 Diabetes: To D or not to D |
2:30 PM | Molecular Aspects of the Role of Vitamin D in Muscle Function |
3:00 PM | Level of Vitamin D Affects Physical and Cognitive Function in Older Persons |
3:30 PM | Networking Coffee Break |
4:00 PM | Keynote AddressVitamin D Dietary Reference Intakes: Navigating the Recommendations |
4:45 PM | Panel DiscussionWhat are the Research Gaps and Critical Next Directions in Vitamin D Research? Moderator Panelists |
5:20 PM | Closing RemarksGary Fanjiang, MD, MBA, MS, Abbott Nutrition Health Institute |
5:30 PM | Networking Reception with Poster Session |
7:00 PM | Conference Adjourns |
Speakers
Organizers
Heike Bischoff-Ferrari, MD, MPH
University of Zurich
Martin Hewison, PhD
University of California Los Angeles
Dr Hewison is currently Professor in Residence at the David Geffen School of Medicine UCLA where his group has an established interest in the role of vitamin D in human physiology, and in particular the interaction between vitamin D and the immune system. Dr Hewison gained his PhD in Biochemistry from Guy's Hospital Medical School London and then spent nine years at University College London. He then moved to the University of Birmingham where he established the UK's major vitamin D research group, leading to an appointment as Professor in Molecular Endocrinology in 2004. In 2005 he joined Cedars-Sinai Medical Center Los Angeles but was then recruited to neighboring UCLA at the end of 2007. Dr Hewison has published over 160 peer-reviewed manuscripts focused on various facets of steroid hormone endocrinology. He currently has a team of three postdocs, a clinical fellow and two PhD students and his work supported by NIH and March of Dimes funding.
Nabeeha Mujeeb Kazi, MIA, MPH
Humanitas Global Development
Hawley K. Linke, PhD
Abbott Nutrition
Hawley K. Linke is a Senior Scientist in the Global Discovery Group at Abbott Nutrition. Her early expertise arose from postdoctoral studies in mitochondrial gene identification at Stanford University Medical School and study of human viral gene expression for her PhD from UCLA's Molecular Biology Institute and related investigations at the Salk Institute. She joined Abbott Laboratories Diagnostics Division, Hepatitis-AIDS investigation group, before transferring to Abbott Nutrition. Her contributions to nutrition research include the development and exploitation of industrial scale expression technologies producing genetically modified and unmodified human proteins for nutritional applications; and conduct of clinical studies demonstrating therapeutic innovations in infant formula. As a subject matter expert regarding vitamin D, she advises the division on nutritional products to optimize the pleiotropic health benefits of this molecule and has authored review articles (in press). Innovation areas for which she maintains technical evaluation and theoretical R&D support include technologies for women's health, neurogastroenterology, and manipulation of the microbiome. Dr. Linke enjoys serving annually as a judge for the Collegiate Inventors Competition created by Invent Now.
Rosemary E. Riley, PhD, LD
Abbott Nutrition Health Institute
Rosemary E. Riley, PhD, LD, is senior manager, science programs for the Abbott Nutrition Health Institute, where she is responsible for developing and directing programs that educate health care professionals throughout the world on the importance of nutrition as therapy to improve patient outcomes. While at Abbott, Rosemary has worked on a variety of nutrition initiatives, including a comprehensive, multidisciplinary medically supervised weight management program, geriatric nutrition, sports nutrition, women's health— with a focus on bone health—and diabetes. She also has experience in strategic discovery and evaluation of ingredients and technology to address these same health conditions.
Carol L. Wagner, MD
Medical University of South Carolina
Mandana Arabi, MD, PhD
The Sackler Institute for Nutrition Science
Brooke Grindlinger, PhD
The New York Academy of Sciences
Keynote Speaker
Daniel D. Bikle, MD, PhD
University of California San Francisco and VA Medical Center
Daniel D. Bikle is Professor of Medicine and Dermatology at the University of California, San Francisco, and Co-director of the Special Diagnostic and Treatment Unit of the San Francisco VA Medical Center. He has a long history in the area of vitamin D, performing a number of the initial studies in its metabolism in the kidney and more recently its extrarenal metabolism in the skin. These latter studies enabled Dr. Bikle and his collaborators to clone and sequence the human enzyme, CYP27B1, responsible for 1,25 dihydroxy vitamin D (1,25(OH)2D) production, the most biologically active metabolite of vitamin D. Much of Dr. Bikle's recent research has focused on the molecular mechanisms by which 1,25(OH)2D and its receptor (VDR) regulate gene expression, in particular during normal epidermal differentiation, wound healing, and hair follicle cycling and the pathologic changes underlying epidermal carcinogenesis. Dr. Bikle is also a practicing Endocrinologist with particular interest in metabolic bone disease, and has written extensively on the interface between the laboratory and clinic with respect to the implications of the recent research in vitamin D function and its impact on patient care.
Speakers
Ricardo Boland, PhD
Universidad Nacional del Sur, Argentina
Dr. Ricardo Boland is Superior Investigator of the National Research Council (CONICET) and Director of the Biological Chemistry Laboratories at the Universidad Nacional del Sur, Argentina. Dr. Boland obtained his PhD in Biochemistry at the University of Missouri- Columbia. He completed postdoctoral training at St. Louis University School of Medicine and the Max-Planck Institute for Medical Research, Heidelberg. He served as President of the Argentinean Societies for Biochemistry and Molecular Biology and of Bone and Mineral Research. Dr. Boland´s research career has been mainly focused on the actions of vitamin D3 on skeletal muscle functions. His major contributions are the identification of the vitamin D receptor (VDR) in this tissue, the characterization of signal transduction pathways involved in the regulation of the Ca2+ messenger system and myogenesis by 1α,25(OH)2-vitamin D3, and the demonstration of a functional role of the VDR in these events.
Sylvia Christakos, PhD
UMDNJ–New Jersey Medical School
Sylvia Christakos, PhD, is Professor of Biochemistry and Molecular Biology and at the University of Medicine and Dentistry of New Jersey (UMDNJ)–New Jersey Medical School in Newark, New Jersey, USA. Dr. Christakos received her PhD degree from the State University of New York (SUNY) at Buffalo School of Medicine. She completed her postdoctoral training at the Roswell Park Memorial Institute, Buffalo, NY, SUNY Buffalo School of Medicine Department of Biochemistry, and at the University of California at Riverside, California, Department of Biochemistry. In 1980 she was appointed as Assistant Professor in the Dept of Biochemistry UMDNJ–New Jersey Medical School, Associate Professor from 1985–1990 and Professor from 1990–present. From 1995–2004 Dr. Christakos was the Graduate Program Director of the Department of Biochemistry. Dr. Christakos has received continuous funding from the National Institutes of Health (NIH) and National Science Foundation (NSF) for the past 30 years. Dr. Christakos' laboratory is one of the leading laboratories involved in research related to vitamin D, its function and mechanism of action. For the past 30 years, her laboratory has combined studies related to the functional significance of vitamin D target proteins using animal models with studies related to the molecular mechanism of 1,25(OH)2D3 action.
Dr. Christakos has served on the NSF regulatory biology study panel, NIH study sections (including General Medicine B and Skeletal Biology, Structure and Regeneration) and the Veteran Administration's Endocrinology Merit Review Board. Dr. Christakos was Associate Editor of The Primer on Metabolic Bone Diseases and Disorders of Mineral Metabolism (2000–2007) and the Journal of Bone and Mineral Research (2003–2008). She is the author or co-author of 157 publications in peer reviewed journals. Dr. Christakos is a member of the American Society for Bone and Mineral Research (ASBMR) (1980–present) and the Endocrine Society. She is a recipient of the Gideon Rodan Mentorship Award from ASBMR. She has served on numerous ASBMR committees and was ASBMR President (2004–2005).
Luigi Ferrucci, MD, PhD
National Institute on Aging
Dr. Luigi Ferrucci is a geriatrician and an epidemiologist who conducts research on the causal pathways leading to progressive physical and cognitive decline in older persons. Dr. Ferrucci has made major contributions in the design of many epidemiological studies conducted in the U.S. and in Europe, including the European Longitudinal Study on Aging, the "ICareDicomano Study," the AKEA study of Centenarians in Sardinia and the Women's Health and Aging Study. He was also the Principal Investigator of the InCHIANTI study, a longitudinal study conducted in the Chianti Geographical area (Tuscany, Italy) looking at risk factors for mobility disability in older persons. Dr. Ferrucci has refined the design of the BLSA to focus more on normal aging, age-associated frailty and factors associated with exceptionally healthy aging and longevity.
David G. Gardner, MD
University of California San Francisco
Dr. David G. Gardner received an MS (Biochemistry) and MD with Honors and Distinction in Research from the University of Rochester in 1974. He completed his residency training in Internal Medicine at the Massachusetts General Hospital (1974–76) before moving to the NIH to complete his fellowship in the Combined Endocrinology Training Program (1976–79) at that institution. In 1979 he accepted an appointment as Adjunct Instructor in Medicine at the University of California at San Francisco. He is currently the Mount Zion Health Fund Distinguished Professor of Medicine and Chief, Division of Endocrinology and Metabolism at UCSF. His research interests are concentrated in cardiovascular endocrinology—particularly on the regulation of cardiovascular and renal function by vitamin D.
Martin Hewison, PhD
University of California Los Angeles
Dr Hewison is currently Professor in Residence at the David Geffen School of Medicine UCLA where his group has an established interest in the role of vitamin D in human physiology, and in particular the interaction between vitamin D and the immune system. Dr Hewison gained his PhD in Biochemistry from Guy's Hospital Medical School London and then spent nine years at University College London. He then moved to the University of Birmingham where he established the UK's major vitamin D research group, leading to an appointment as Professor in Molecular Endocrinology in 2004. In 2005 he joined Cedars-Sinai Medical Center Los Angeles but was then recruited to neighboring UCLA at the end of 2007. Dr Hewison has published over160 peer-reviewed manuscripts focused on various facets of steroid hormone endocrinology. He currently has a team of three postdocs, a clinical fellow and two PhD students and his work supported by NIH and March of Dimes funding.
Lily Li, BA
Mount Sinai School of Medicine
Lily Li is a third year medical student at the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University. After receiving her BA with Distinction in Biology from Carleton College, Lily completed a year-long Post-baccalaureate Intramural Research Training Award Program in immunology at the National Institutes of Health. She is currently pursuing a 1-year Doris Duke Clinical Research Fellowship at the Mount Sinai School of Medicine, and is working with Drs. Peter Heeger and Anita Mehrotra in the Department of Medicine.
Anastassios G. Pittas, MD
Tufts Medical Center
Dr. Pittas is an Associate Professor of Medicine at Tufts University School of Medicine, an Adjunct Associate Professor of Nutrition and Policy at Tufts University Friedman School of Nutrition, Science and Policy and a Center Scientist at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. He received his BS degree from Massachusetts Institute of Technology and his MD degree from Cornell University Medical College. After completing his Internal Medicine Residency at the New York Presbyterian Hospital in New York City, NY and his Fellowship in Endocrinology at Tufts Medical Center, Boston, MA, he joined the staff in the Division of Endocrinology, Diabetes, and Metabolism at Tufts Medical Center where he has been active in all three areas of academic medicine: clinical care, research, and teaching, as they relate to the prevention and treatment of diabetes mellitus. Dr. Pittas serves as the Co-director of the Dr. Gerald J. and Dorothy R. Friedman New York Foundation for Medical Research Diabetes Self-education Program and as the Associate Director of the Endocrinology Fellowship program. He also served as the Director of the Endocrine Pathophysiology course at Tufts University School of Medicine from 2000 to 2008. Dr. Pittas earned his MS degree in Clinical Research from Sackler School of Biomedical Sciences at Tufts University in 2006. He is Diplomat of the American Board in Endocrinology and Metabolism. Dr. Pittas was the recipient of a National Institutes of Health K23 Career Development Award. His work on the role of vitamin D and calcium in cardiometabolic disease has been supported by the R01, R21 and U34 mechanisms of the National Institutes of Health (NIDDK and ODS) and the American Diabetes Association. His additional interest is in Comparative Effectiveness Research (CER) as it relates to the care of patients with diabetes. He has co-authored over 60 publications including peer-reviewed journals, books, book chapters, and evidence-based reports. Dr. Pittas has been a peer-reviewer for NIH study sections and for other international research foundations including the Canadian Institutes of Health Research, UK Diabetes, Children's Medical Research Foundation (Australia), and Health Research Council of New Zealand. He has also been a peer reviewer for major medical journals including Annals of Internal Medicine, Archives of Internal Medicine, The Lancet, and The Canadian Medical Association Journal. He is a member of various professional societies.
Erica Rutten, PhD
Ciro +, Centre of Expertise for Chronic Organ Failure
After her study on nutrition in the Catholic University Leuven in Leuven, Belgium, Dr. Rutten moved to Maastricht University in Maastricht, the Netherlands, for a PhD project on amino acid metabolism in patients with chronic obstructive pulmonary disease (COPD). After graduating, she was appointed by the Program Development Centre of the Centre of Expertise for Chronic Organ Failure (CIRO+) in Horn, the Netherlands. She is the theme leader of the topic body composition, nutrition, and metabolism. In 2008, Dr. Rutten received a research grant from the Dutch Asthma Foundation for work titled "Systemic Manifestation and Co-morbidity in COPD are Associated with Markers of Accelerated Aging." She is also interested in malnutrition in COPD, obesity, osteoporosis, vitamin D, and nutritional intake in patients with chronic disease.
Igor N. Sergeev, PhD, DSc
South Dakota State University
Dr. Sergeev has over 25 years of experience in academic research in biochemistry and nutrition. Dr. Sergeev received a PhD in 1984 from Institute of Biomedical Problem, Moscow, Russia and a DSc in 1991 from Institute of Nutrition, Moscow, Russia. As professor of nutritional sciences at South Dakota State University, he directs research program in nutritional biochemistry and molecular nutrition. Dr. Sergeev achieved an international reputation through his work on vitamin D metabolism, vitamin D receptors, and calcium signaling. In the last decade, he has been recognized for his research on the role of cellular calcium and vitamin D in the regulation of apoptosis. Dr. Sergeev's research is featured in over 100 major scientific publications. Among his most cited publications are articles in the Journal of Biological Chemistry, Endocrinology, and the Journal of Steroid Biochemistry and Molecular Biology. Dr. Sergeev has received a number of awards, including prestigious recognitions from the Academy of Medical Sciences (Russia), the Visiting Researcher award from University of California, Riverside, and the Wellcome Trust Senior Research Fellowship in Medical Science.
Carol L. Wagner MD
Medical University of South Carolina
As an academic neonatologist for more than 20 years, Dr. Carol Wagner has been involved in basic science, translational and clinical studies. She is a graduate of Brown University and the Boston School of Medicine, receiving her MD degree in 1986. She then completed both her Pediatric residency and Neonatal–Perinatal fellowship at the University of Rochester, completing her post-doctoral training in 1992. She accepted a faculty position at the Medical University of South Carolina in that same year, where she continues to work as Professor of Pediatrics and Associate Director of the Clinical and Translational Research Center. Dr. Wagner's current research interests are vitamin D requirements during pregnancy and lactation and human milk bioactivity and its effect on gut maturation.
Working with colleague Dr. Bruce Hollis, Drs. Hollis and Wagner undertook a series of ground-breaking pilot studies to ascertain the vitamin D requirements of lactating women and their infants from which three randomized control trials were born: NIH #R01 HD043921; R01 HD047511, and Thrasher Research Fund (#02823). These studies addressed the hormonal and more basic mechanism of vitamin D metabolism during states of both deficiency and sufficiency unique to pregnancy and lactation. Dr. Wagner is also the PI of an ongoing follow-up study of the original NICHD and Thrasher pregnancy cohorts funded by the Thrasher Research Fund with the objective of better understanding the long-term effects of fetal vitamin D status on later development, growth and immune function during childhood. She is a recent recipient of a project funded by the Kellogg Foundation to study the effect of vitamin D repletion on health disparities and outcomes during pregnancy, and to translate these findings into public health policies. Based on the team's ongoing work, Dr. Wagner will present the evidence about vitamin D requirements during pregnancy and lactation and the implication of deficiency during these critical times during the lifecycle.
Sponsors
Presented by
This event is sponsored by an unrestricted educational grant from Abbott Nutrition Health Institute.
Promotional Partners
American Society for Nutrition
The Council for Responsible Nutrition (CRN)
Greater New York Dietetic Association
The Journal of Clinical Investigation
Nature Publishing Group
Nutrition & Diabetes
Abstracts
Session I: Non-Classical Effects of Vitamin D
Vitamin D Biology Beyond Bone
Sylvia Christakos, PhD, UMDNJ-New Jersey Medical School
Vitamin D in Immune Function and Disease Prevention
Martin Hewison, PhD, University of California Los Angeles
Role of the Vitamin D Receptor in the Cardiovascular System
David G. Gardner, MD, University of California San Francisco
Vitamin D during Pregnancy and Lactation: Emerging Concepts
Carol L. Wagner, MD, Medical University of South Carolina
Session II: Early Career Investigator Presentations
The Role of Vitamin D in Regulation of Apoptotic Signaling Pathways in Obesity
Igor N. Sergeev, PhD, DSc, South Dakota State University
Plasma Vitamin D is Independently Associated with Lung Function in Patients with Chronic Obstructive Pulmonary Disease (COPD)
Erica Rutten, PhD, Ciro +, Centre of Expertise for Chronic Organ Failure
Impact of Cholecal Ciferol Repletion on Erythropoietin Requirements in Vitamin D-Deficient Hemodialysis Patients: Pilot Data from a Randomized Controlled Trial
Lily Li, BA, Mount Sinai School of Medicine
Session III: Translating Epidemiological Data into Policy and Clinical Applications in Adult and Aging Populations
Vitamin D for Type 2 Diabetes; to D or not to D
Anastassios G. Pittas, MD, Tufts Medical Center
Molecular Aspects of the Role of Vitamin D in Muscle Function
Ricardo Boland, PhD, Universidad Nacional del Sur, Argentina
Level of Vitamin D Affects Physical and Cognitive Function in Older Persons
Luigi Ferrucci, MD, PhD, National Institute on Aging, NIH
Keynote Address
Vitamin D Dietary Reference Intakes: Navigating the Recommendations
Daniel D. Bikle, MD, PhD, University of California San Francisco and VA Medical Center
Travel & Lodging
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