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Bioorthogonal Chemistry in Biology and Medicine
Wednesday, December 11, 2013
Innovations in chemistry have been essential for major breakthroughs in biology and medicine. At the heart of bioorthogonal chemical reactions is the development of uniquely reactive functional groups that allows specific covalent ligation of molecules in biological systems. Despite the challenges of performing specific chemical reactions in biological settings, a variety of bioorthogonal ligation methods such as native chemical ligation, Staudinger ligation and many cycloaddition reactions have been developed. The application of these bioorthogonal chemistries to biology through functionalized chemical reporters has enabled the imaging and large-scale analysis of nucleic acids, proteins, glycans, lipids and other metabolites in vitro as well as in vivo, in all kingdoms of life including bacteria, plants and mammals. In addition to monitoring biomolecules, bioorthogonal chemistry has allowed the functionalization of molecules for target identification of drugs and semi-synthesis of biomolecules for basic science as well as diagnostic and therapeutic agents. This symposium will highlight recent advances in bioorthogonal chemistry that have afforded unprecedented opportunities to explore biology and facilitated the synthesis of diagnostics and therapeutics for medicine. Oral and poster presentations will showcase ongoing applications and developments of bioorthogonal chemistry and discuss new frontiers and challenges for chemical biology.
*Networking reception to follow.
Registration Pricing
Member | $0 |
Student/Postdoc Member | $0 |
Nonmember | $40 |
Nonmember (Student / Postdoc / Resident / Fellow) | $20 |
The Chemical Biology Discussion Group is proudly supported by 
Mission Partner support for the Frontiers of Science program provided by 
Agenda
* Presentation titles and times are subject to change.
December 11, 2013 | |
12:00 PM | Registration and poster set-up |
12:30 PM | Welcome and Introduction |
12:40 PM | Chemical Reporters for Biological Discovery: Dissection of Protein S-Palmitoylation in Cellular Differentiation |
1:15 PM | Early career investigator presentation |
1:35 PM | Coffee Break and Poster Session |
2:20 PM | Early career investigator presentation |
2:40 PM | Implementing Bioorthogonal Chemistry to Interrogate Protein Methyltransferases As Epigenomic Regulators |
3:15 PM | Keynote presentation |
4:00 PM | Networking Reception and Poster Session |
5:00 PM | Close |
Speakers
Organizers
Howard C. Hang, PhD
The Rockefeller University
Dr Hang received his undergraduate degree in chemistry from the University of California, Santa Cruz, in 1998 with Prof. Joseph Konopelski and his PhD in chemistry from the University of California, Berkeley, in 2003 with Prof. Carolyn Bertozzi. He was a Damon Runyon Cancer Research Foundation postdoctoral fellow at Harvard Medical School and the Whitehead Institute for Biomedical Research with Prof. Hidde Ploegh. He joined Rockefeller in 2007 as assistant professor and head of laboratory and was appointed associate professor in 2013.
Jennifer S. Henry PhD
The New York Academy of Sciences
Speakers
T. Eric Ballard, Jr, PhD
Pfizer Worldwide Research and Development
Dr. Eric Ballard is a Principal Scientist in the Biotransformation group in Pharmacokinetics, Dynamics and Metabolism at Pfizer. In his current role, Eric investigates the clearance mechanisms and metabolism of small molecules in support of early and late stage research and development. Prior to his current position, Eric was a Postdoctoral Fellow in the Worldwide Medicinal Chemistry Group at Pfizer where he investigated the design and synthesis of clickable photoaffinity-based small molecule probes and their application to mechanism-of-action studies in neurologic and psychiatric disorders. Preceding his time at Pfizer, Eric was a Postdoctoral Associate in Prof. Timothy MacDonald's lab at the University of Virginia where he worked on the synthesis of small molecule inhibitors of the PFOR enzyme present in anaerobic pathogenic bacteria. Eric received his PhD in Organic Chemistry in 2008 from North Carolina State University under the direction of Prof. Christian Melander. He has coauthored numerous publications on organic synthesis, bioorganic chemistry, chemical biology and metabolism.
Joseph M. Fox, PhD
University of Delaware
Joseph M. Fox is Professor of Chemistry and Biochemistry at the University of Delaware.
Fox received his bachelor’s degree from Princeton University, where he conducted undergraduate research as a Pfizer fellow with Maitland Jones Jr. He completed graduate studies under Thomas Katz at Columbia University, where he developed a combined interest in materials science and the synthesis of challenging targets. He studied organometallic chemistry with Stephen Buchwald at MIT as an NIH postdoctoral fellow, where he worked on Pd-catalyzed ketone arylation and devised a synthesis of phosphine ligands that is now used commercially.
In 2001, Fox joined the faculty at UD, and he has built a multidisciplinary program that centers on the development of new types of chemical reactions. His group has developed new syntheses and transformations of chiral cyclopropenes and trans-cycloalkenes, and a new type of bioorthogonal reaction that allows for extremely rapid conjugation to biological macromolecules. Applications of this work include synthesis of naturally occurring and designed molecules with biological function, and in the use of design concepts in organic synthesis for applications in biology, nuclear medicine, imaging, therapy and materials science. He was promoted to the rank of Professor in 2011. His awards include the NSF Career Award and the University of Delaware Outstanding Doctoral Student Advising and Mentoring Award.
Howard C. Hang, PhD
The Rockefeller University
Dr Hang received his undergraduate degree in chemistry from the University of California, Santa Cruz, in 1998 with Prof. Joseph Konopelski and his PhD in chemistry from the University of California, Berkeley, in 2003 with Prof. Carolyn Bertozzi. He was a Damon Runyon Cancer Research Foundation postdoctoral fellow at Harvard Medical School and the Whitehead Institute for Biomedical Research with Prof. Hidde Ploegh. He joined Rockefeller in 2007 as assistant professor and head of laboratory and was appointed associate professor in 2013.
Minkui Luo, PhD
Memorial Sloan-Kettering Cancer Center
Dr. Luo is an Assistant Professor and Assistant Member in the program of Molecular Pharmacology and Chemistry Program at Memorial Sloan-Kettering Cancer Center. Dr. Luo received PhD from Princeton University with the major in bioorganic and chemical biology, and then conducted his postdoctoral training at Albert Einstein College of Medicine with the focus on developing tight-binding transition-state inhibitors. Dr. Luo accumulated multiple-year experiences to develop chemical tools to define, perturb and manipulate essential functions of enzymes. Dr. Luo has published more than 30 peer-reviewed papers in the field of chemistry and chemical biology in well-recognized peer-reviewed journals. He has also received many awards and honors, such as the Basil O'Connor Starter Scholar, NIH Director’s New Innovator Award, Alfred W. Bressler Scholar, and the V Scholar Award for Cancer Research.
Lisa Shah
SUNY Stony Brook
Lisa Shah received her BS in Chemistry from New York University in 2011 and is currently a doctoral candidate at Stony Brook University under the advisement of Dr. Isaac Carrico. She is a fellow of both the NIH-funded Chemical Biology Training Program and the US Department of State/New York Academy of Science NeXXt Scholars Program. Her research interests broadly and briefly include developing bioorthogonal chemical tools to probe biology, elucidating bacterial kinase signal transduction pathways, and understanding the role of PTMs in cancer cell biology.
Sponsors
Academy Friend
Promotional Partner
The Chemical Biology Discussion Group is proudly supported by 
Mission Partner support for the Frontiers of Science program provided by 
Abstracts
Chemical Reporters for Biological Discovery: Protein S-Palmitoylation in Cellular Differentiation and Innate Immunity
Howard Hang, PhD, The Rockefeller University
Photocaging the Staudinger Reagent for Increased Spatial and Temporal Control of the Chemoselective Reaction in vivo
Lisa Shah, Department of Chemistry, SUNY Stony Brook
Coauthor: Isaac S. Carrico, PhD, Department of Chemistry, SUNY Stony Brook
Implementing Bioorthogonal Chemistry to Interrogate Protein Methyltransferases as Epigenomic Regulators
Minkui Luo, PhD, Memorial Sloan-Kettering Cancer Center
trans-Cyclooctene— a stable, voracious dienophile for bioorthogonal labeling
Joseph M. Fox, PhD, University of Delaware
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