
The Bone Marrow Niche, Stem Cells, and Leukemia: Impact of Drugs, Chemicals, and the Environment
Wednesday, May 29, 2013 - Friday, May 31, 2013
Presented By
Over 20,000 Americans are diagnosed each year with bone marrow failure syndromes. Environmental, chemical, and genetic factors have been linked to the development of lymphomas, leukemias, and myelodysplastic syndromes (MDS). Additionally, some anti-cancer drugs have been shown to themselves induce DNA damage and secondary cancers. In light of increasing societal exposure to toxic environmental agents that may be carcinogenic, including chemicals and pharmaceuticals, we face the potential for a rise in the incidence of bone marrow failure and malignancy. In order to better understand leukemia it may be necessary to examine it from the perspective that it is an environmental disease.
To date, two separate groups of scientists and physicians have been studying bone marrow: toxicologists who examine the effects of chemicals and the environment on healthy marrow, and hematologists and oncologists who investigate bone marrow abnormalities and malignancies. Thus, there is a clear, unmet need for collaboration between these fields within academia, industry, and government in order to accelerate our investigation and understanding both of basic bone marrow biology and chemically-induced diseases of the marrow.
This 2.5-day conference will bring together representatives from two areas of research, toxicology and hematology, around a jointly shared goal — to better understand, prevent, and treat myeloid neoplasms. Conference Sessions will combine basic science and toxicology research at the level of the bone marrow niche with clinical findings from healthy subjects and patients. Topics for discussion will include bone marrow niche structure and function, the maturation and differentiation of healthy and leukemogenic hematopoietic stem cells, and the environmental, chemical, and genetic factors involved in the development of myeloid abnormalities including MDS and acute myeloid leukemia (AML). The meeting will feature a series of plenary lectures, panel discussions, a poster session, and short talk presentations selected from abstracts submitted by early career investigators.
Organizing Committee*
Conference Organizers
Michael A. Gallo, PhD
Robert Wood Johnson Medical School and Environmental and Occupational Health Sciences Institute; Rutgers, The State University of New Jersey
Helmut Greim, MD
Technical University of Munich
Robert Snyder, PhD (Chair)
Environmental and Occupational Health Sciences Institute; Rutgers, The State University of New Jersey
Subcommittee Chairs
Finance:
Robert Snyder, PhD
Environmental and Occupational Health Sciences Institute; Rutgers, The State University of New Jersey
International Advisory Committee:
Helmut Greim, MD
Technical University of Munich
Logistics:
Debra Kaden, PhD
Environ International Corporation
Programs:
Richard Larson, MD
University of Chicago
David Ross, PhD
University of Colorado Anschutz Medical Campus
Publications:
Jerry M. Rice, PhD
Georgetown University Medical Center
* Please click on the Speakers tab for a complete listing of the Organizing Committee
Registration Pricing
By 4/26/2013 | After 4/26/2013 | Onsite | |
Member | $350 | $400 | $500 |
Student/Postdoc Member | $200 | $250 | $300 |
Nonmember (Academia) | $400 | $450 | $550 |
Nonmember (Corporate) | $500 | $550 | $650 |
Nonmember (Non-profit) | $400 | $450 | $550 |
Nonmember (Student / Postdoc / Fellow) | $200 | $250 | $300 |
Registration includes a complimentary, one-year membership to the New York Academy of Sciences. Complimentary memberships are provided to non-members only and cannot be used to renew or extend existing or expiring memberships. A welcome email will be sent upon registration which will include your membership credentials.
Presented by
Agenda
* Presentation times are subject to change.
Day 1 — Wednesday, May 29, 2013 | |
8:00 AM | Breakfast and Registration |
8:45 AM | Opening Remarks |
Session I. Stem Cells, the Niche and Myeloid NeoplasmsSession Chairs: Richard D. Irons, PhD, Fudan University; Dorothy A. Sipkins, MD, PhD, The University of Chicago | |
9:15 AM | Normal and Neoplastic Stem Cells |
9:45 AM | Myeloproliferative Neoplasm Development Remodels the Osteoblastic Bone Marrow Niche and Promotes Myelofibrosis |
10:15 AM | Niche Targeting of Leukemia Stem Cells |
10:45 AM | Networking Break |
11:15 AM | Niche and Signaling Regulation of the State and Fate of Stem Cells |
11:45 AM | Niche Initiated Oncogenesis |
12:15 PM | Contribution of the Reprogrammed Vascular Niche to Stem Cell Self-Renewal and Organ Regeneration |
12:45 PM | Discussion Panel |
1:00 PM | Networking Lunch |
Session II. Stem Cell Signaling and the NicheSession Chairs: David Ross, PhD, University of Colorado Anschutz Medical Campus; Emmanuelle Passegué, PhD, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco | |
2:00 PM | Niche-Secreted Factors Regulate Stem Cell Behavior |
2:30 PM | The Ah Receptor in Stem Cell Cycling, Regulation and Quiescence |
3:00 PM | Stress Induced Activation of Hematopoietic Stem Cells In Vivo |
3:30 PM | Networking Break |
4:00 PM | Aldehyde Dehydrogenases in Normal and Malignant Hematopoietic Stem Cells |
4:30 PM | Niche Regulation for Hematopoietic Stem Cells |
5:00 PM | Apoptosis-Related Gene Expression Profiling of Hematopoietic Stem/Progenitor Cells After Radiation Exposure |
5:30 PM | Discussion Panel |
5:45 PM | Short Talks Selection Endothelial Cells Expressing Constitutively Active AKT1 Combined With Mesenchymal Stem Cells Are Capable of Reconstituting Bone Marrow Niche In Vitro Reconstructing the Human Hematopoietic Niche: Opportunities for Studying Normal and Malignant Hematopoiesis |
6:15 PM | Poster Session and Networking Reception |
8:00 PM | Close of Day 1 |
Day 2 — Thursday, May 30, 2013 | |
7:45 AM | Registration and Breakfast |
8:00 AM | Early-Career Investigator Training: Writing for Scientific Publication |
Session III. Dysregulation of Gene Expression in Myeloid NeoplasmsSession Chairs: Michelle M. Le Beau, PhD, The University of Chicago Comprehensive Care Center; Martyn T. Smith, PhD, University of California, Berkeley | |
9:00 AM | Epigenetic Mechanisms and Therapeutics |
9:30 AM | Gene Expression in Myelodysplastic Syndromes and Acute Myeloid Leukemia |
10:00 AM | Role of Mutations In Epigenetic Regulators in Pathogenesis of Myeloid Malignancies |
10:30 AM | MicroRNAs in Myeloid Leukemia |
11:00 AM | Networking Break |
11:30 AM | Application of Genome-Wide Profiling to Evaluate Effects of Benzene and its Metabolites from Yeast to Human |
12:00 PM | Benzene Cytogenetics, Myelodysplasia and Acute Myeloid Leukemia: New Insights Into a Disease Continuum |
12:30 PM | Preventing Leukemogenic Chromosomal Translocations |
1:00 PM | Discussion Panel |
1:15 PM | Networking Lunch |
Session IV. Therapy Related Myeloid NeoplasmsSession Chairs: David Eastmond, MS, PhD, University of California, Riverside; Richard Larson, MD, The University of Chicago | |
2:30 PM | Genetics of Therapy-Related Myelodysplastic Syndromes and Acute Myeloid Leukemia |
3:00 PM | Genetic Pathways Leading to Alkylating Agent-Induced Therapy-Related Myeloid Neoplasms |
3:30 PM | Topoisomerase II and Leukemia |
4:00 PM | Networking Break |
4:30 PM | Familial Myelodysplastic Syndromes/Acute Myeloid Leukemia and Germline RUNX1 Mutations |
5:00 PM | The Genetics of Therapy-Induced Second Cancer Risk |
5:30 PM | Discussion Panel |
5:45 PM | Short Talks Selection Investigation into the Cross Talk Between Acute Myeloid Leukemia Cells and the Bone Marrow Microenvironment Functional Analysis of the Bone Marrow Microenvironment in Myelodysplastic Syndrome: Targeting the Disease Niche |
6:15 PM | Close of Day 2 |
Day 3 — Friday, May 31, 2013 | |
8:30 AM | Breakfast |
Session V. Models and ToolsSession Chairs: Lucy A. Godley, MD, PhD, The University of Chicago; Robert Oostendorp, PhD, Technical University of Munich | |
9:00 AM | Regulation of Leukemia Cell Dormancy by The Bone Marrow Niche |
9:30 AM | Methods to Analyze Homing of Stem Cells in Bone Marrow |
10:00 AM | Modeling Exposure-Induced Leukemogenesis in the Mouse |
10:30 AM | Networking Break |
11:00 AM | Redox Proteomics for Measurement of Oxidative Stress |
11:30 AM | Long-term Quantitative Single Cell Imaging: New Tools for Old Questions |
12:00 PM | Genome-Exposome Interactions in Leukemia Etiology |
12:30 PM | Discussion Panel |
12:45 PM | Closing Remarks |
1:00 PM | Close of Conference |
Speakers
Speakers
Mette Klarskov Andersen, MD, PhD
Rigshospitalet, Denmark
Jane E. Churpek, MD
University of Chicago Hospitals
Marieke Essers, PhD
Heidelberg Institute for Stem Cell Technology and Experimental Medicine; German Cancer Research Center
Thomas A. Gasiewicz, PhD
University of Rochester Medical Center
Lucy A. Godley, MD, PhD
The University of Chicago
Yoko Hirabayashi, MD
National Institute of Health Sciences
Robert Hromas, MD
University of Florida Department of Medicine
Richard D. Irons, PhD
Fudan University
Dean P. Jones, PhD
Emory University
Michelle M. Le Beau, PhD
The University of Chicago Comprehensive Cancer Center
Linheng Li, PhD
Stowers Institute for Medical Research
Guido Marcucci , MD
Wexner Medical Center at The Ohio State University
Susie K. Nilsson, PhD
Commonwealth Scientific and Industrial Research Organisation (CSIRO)
Stephen Nimer, MD
University of Miami
Kenan Onel, MD, PhD
The University of Chicago
Robert A. J. Oostendorp, PhD
Technical University of Munich
Neil Osheroff, PhD
Vanderbilt University School of Medicine
Emmanuelle Passegué, PhD
The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at University of California, San Francisco
Shahin Rafii, MD
Weill Cornell Medical College
David T. Scadden, MD
Massachusetts General Hospital; Harvard University
Timm Schroeder, PhD
Helmholtz Center Munich
Dorothy A. Sipkins, MD, PhD
The University of Chicago
Martyn T, Smith, PhD
University of California, Berkeley
Clayton Smith, MD
University of Colorado, Denver
Toshio Suda, MD, PhD
School of Medicine, Keio University
Michael J. Thirman, MD
The University of Chicago
Irving Weissman, MD
Stanford University
Luoping Zhang, PhD
School of Public Health, University of California, Berkelely
Organizing Committee
Subcommittee Abbreviations:
FIN | — | Finance Subcommittee |
IAC | — | International Advisory Committee |
LOG | — | Logistics Subcommittee |
PRO | — | Programs Subcommittee |
PUB | — | Publications Subcommittee |
* Denotes Subcommittee Chair/Co-Chair |
Patrick Beatty, PhD [FIN]
American Petroleum Institute
Hermann Bolt, MD, PhD [IAC]
University of Dortmund
David Eastmond, MS, PhD [PRO]
University of California, Riverside
John E. French, PhD [PRO, PUB]
National Institute for Environmental Health Sciences, National Institutes of Health
Michael A. Gallo, PhD [FIN, PRO, PUB]
Robert Wood Johnson Medical School and Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey
Bernard D. Goldstein, MD
University of Pittsburgh
Helmut Greim, MD [FIN, IAC*]
Technical University of Munich
Rogene Henderson, PhD
Lovelace Respiratory Research Institute
Yoko Hirabayashi, MD [IAC]
National Center for Biological Safety and Research, National Institute of Health Sciences, Japan
Tohru Inoue, MD, PhD [IAC]
ToxSCO (ToxSafety Consultations) and Nihon University School of Medicine
Richard D. Irons, MT, PhD [IAC, PRO]
University of Colorado, Fudan University, and Cinpathogen Inc.
Debra Kaden, PhD [LOG*, PUB]
Environ International Corporation
Richard Larson, MD [IAC, PRO*, PUB]
University of Chicago
Serrine S. Lau, PhD
University of Arizona
Terrance J. Monks, PhD
University of Arizona
Eileen Murphy, PhD [FIN, LOG]
Rutgers, The State University of New Jersey
Franz Oesch, PhD [IAC]
University of Mainz
Robert A. J. Oostendorp, MD [IAC, PRO]
Technical University of Munich
Christine Palermo, PhD, DABT [FIN, LOG, PUB]
ExxonMobil Biomedical Sciences, Inc.
David Pyatt, PhD [LOG]
Summit Toxicology, LLP and University of Colorado
Jerry M. Rice, PhD [FIN, PUB*]
Georgetown University Medical Center
David Ross, PhD [PRO*, PUB]
University of Colorado Anschutz Medical Campus
A. Robert Schnatter, MS, MSc, DPh
ExxonMobil Biomedical Sciences, Inc.
Dieter Schrenk, MD, PhD [IAC]
University of Kaiserlauthern
Dorothy Sipkins, MD [PRO]
University of Chicago
Martyn T. Smith, PhD
University of California, Berkeley
Babasaheb R. Sonawane, PhD
U.S. Environmental Protection Agency
Robert Snyder, PhD [FIN*, IAC, LOG]
Environmental and Occupational Health Sciences Institute; Rutgers, The State University of New Jersey
Michael A. Trush, PhD [PRO]
Johns Hopkins Bloomberg School of Public Health
Helmut Zarbl, PhD
Cancer Institute of New Jersey; UMDNJ - Robert Wood Johnson Medical School; Environmental and Occupational Health Sciences Institute; Rutgers, The State University of New Jersey
Luoping Zhang, MS, PhD [PUB]
School of Public Health, University of California, Berkeley
Sponsors
Bronze Sponsors
American Chemistry Council's Center for Advancing Risk Assessment Science and Policy
Academy Friends
European Research Group on Environment and Health in the Transport Sector (EUGT e.V.)
United States Environmental Protection Agency
Grant Support
This conference is supported by an educational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology Company.
Funding for this conference was made possible (in part) by 1R13 ES022912-01 from the National Institute of Environmental Health Sciences and National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Promotional Partners
American Society for Blood and Marrow Transplantation
American Society for Pharmacology & Experimental Therapeutics (ASPET)
American Society of Hematology
Aplastic Anemia & MDS International Foundation
British Society of Toxicological Pathology
Environmental Health Perspectives
European Hematology Association
The Journal of Clinical Investigation
Journal of Experimental Medicine
Keystone Symposia on Molecular & Cellular Biology
The New York Academy of Medicine
Presented by
Abstracts — Day 1
Normal and Neoplastic Stem Cells
Irving Weissman, MD, Stanford University
Myeloproliferative Neoplasm Development Remodels the Osteoblastic Bone Marrow Niche and Promotes Myelofibrosis
Emmanuelle Passegué, PhD, The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, San Francisco
Niche Targeting of Leukemia Stem Cells
Catriona Jamieson, MD, PhD, University of California, San Diego
Niche and Signaling Regulation of the State and Fate of Stem Cells
Linheng Li, PhD, Stowers Institute for Medical Research
Niche Initiated Oncogenesis
David T. Scadden, MD, Massachusetts General Hospital; Harvard University
Contribution of the Reprogrammed Vascular Niche to Stem Cell Self-Renewal and Organ Regeneration
Jason M. Butler, PhD, Bisen Ding, PhD, Daylon James, PhD, Daniel Nolan, PhD, Michael Ginsberg, PhD, Sina Rabbany, PhD, and Shahin Rafii, MD, Weill Cornell Medical College, Ansary Stem Cell Institute; Howard Hughes Medical Institute, New York
After partial hepatectomy, SECs within the liver stimulated regeneration by angiocrine expression of Wnt2 and HGF (Nature, 468(7321):310-5, 2010). Pulmonary capillary ECs (PCECs), by deploying MMP14 and release of EGF ligands, sustain lung regeneration. Notably, transplantation of SECs or PCECs into mice restores organ regeneration (Cell, 47(3):539-53, 2011). These data establish the remarkable tissuespecific vascular heterogeneity in orchestrating organ regeneration.
To translate these findings to the clinical setting, we have differentiated human and mouse embryonic stem and iPSC cells into induced vascular endothelial cells (iVECs) (Cell, 151, 559-75, 2012). However, iVECs are unstable and have limited expansion potential. To circumvent this hurdle, we have developed new strategies by transcriptional reprogramming of amniotic cells into vascular ECs (rAC-VECs) (Cell, 151, 559-75, 2012). rACVECs phenocopy the specialized tissue-specific function of ECs, supporting long-term expansion of repopulating cells (Developmental Cell, In Press), such as hematopoietic stem cells in xenobiotic-free conditions. Given that rACVECs can be HLA-typed, cryopreserved, and publicly banked, these cells could establish an inventory for generating abundant tissue-specific vascular niche cells for promoting angiocrine-dependent organ regeneration.
Niche-Secreted Factors Regulate Stem Cell Behavior
Robert Oostendorp, PhD, Technical University of Munich
The Ah Receptor in Stem Cell Cycling, Regulation and Quiescence
Thomas A. Gasiewicz, PhD, University of Rochester Medical Center
Supported by NIH Grants ES01247, ES07026, and ES04862.
Stress Induced Activation of Hematopoietic Stem Cells In Vivo
Stefanie Thamm, Raphael Lutz, Andrea Kuck, Stephan Wurzer, Marieke A.G. Essers, PhD, HI-STEM and DKFZ
Our work has recently demonstrated that, very surprisingly, the cytokine IFNα, which is produced by virally infected immune cells to block the infection of more mature blood cells, is able to activate the entire HSC pool including dormant HSCs. Activated HSCs start to proliferate in vivo and up-regulate stem cell antigen 1 (Sca-1). In order to explain this surprising effect of IFNα on HSCs, we are currently exploring whether during infections IFNα might be part of a feedback loop leading to the activation of HSCs. Using a reporter mouse to monitor IFNα production in the bone marrow, several forms of bone marrow stress were tested. Interestingly, injection of mice with lipopolysaccharide (LPS) lead to increased IFNα production, followed by a TLR4-dependent activation of quiescent HSCs. Similar to IFNα, LPS induced activation is accompanied by and dependent on up-regulation of Sca-1 on the surface of HSCs. However, though IFNα has a direct effect on HSCs, both in vivo and in vitro experiments show that LPS has an indirect effect on HSCs. We are currently unraveling the mechanism underlying the indirect activation of HSCs in response to LPS and the potential role the bone marrow niche plays in this process. These data will further increase our knowledge on the mechanism of activation of HSCs under stress conditions.
Aldehyde Dehydrogenases in Normal and Malignant Hematopoietic Stem Cells
Clayton Smith, MD, University of Colorado, Denver
Niche Regulation for Hematopoietic Stem Cells
Toshio Suda, MD, PhD, School of Medicine, Keio University
Apoptosis-Related Gene Expression Profiling of Hematopoietic Stem/Progenitor Cells after Radiation Exposure
Yoko Hirabayashi, MD, National Institute of Health Sciences
Travel & Lodging
Our Location
The New York Academy of Sciences
7 World Trade Center
250 Greenwich Street, 40th floor
New York, NY 10007-2157
212.298.8600
Hotels Near 7 World Trade Center
Recommended partner hotel
Club Quarters, World Trade Center
140 Washington Street
New York, NY 10006
Phone: 212.577.1133
The New York Academy of Sciences is a member of the Club Quarters network, which offers significant savings on hotel reservations to member organizations. Located opposite Memorial Plaza on the south side of the World Trade Center, Club Quarters, World Trade Center is just a short walk to the Academy.
Use Club Quarters Reservation Password NYAS to reserve your discounted accommodations online.
Other nearby hotels
212.693.2001 | |
212.385.4900 | |
212.269.6400 | |
212.742.0003 | |
212.232.7700 | |
212.747.1500 | |
212.344.0800 |