Genome Integrity Discussion Group Meeting
Monday, October 6, 2014
The greater New York Metropolitan area has become a leading center for research on chromosome biology and function, as well as for research at the interface between chromosome integrity and onset and progression of malignancy. The connection between cancer and genome integrity is widely appreciated, and the concentration of excellence in this field is unparalleled anywhere in the world. The Genome Integrity meetings are designed to provide a forum for interactions between the many basic science and clinically-oriented research groups working on these issues. We feel that these interactions will not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities will be revealed.
In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions.
Genome Integrity Discussion Group meetings are organized under the leadership of Scott Keeney (Memorial Sloan Kettering Cancer Center), Susan Smith (NYU Langone Medical Center) and Lorraine Symington (Columbia University). This meeting will include a scientific symposium from 1:30 to 4:30 PM, followed by a networking reception from 4:30 to 5:30 PM.
|Member (Student / Postdoc / Resident / Fellow)||$0|
|Nonmember (Student / Postdoc / Resident / Fellow)||$20|
The Genome Integrity Discussion Group is proudly supported by
Mission Partner support for the Frontiers of Science program provided by
Agenda* Presentation titles and times are subject to change.
October 6, 2014
Welcome and Introductory Remarks
Organization and Dynamics of the NHEJ Complex in DNA Double-strand Break Repair
Mammalian Polymerase Theta Promotes Alternative-NHEJ and Suppresses Recombination
Networking Coffee Break
Conserved RAG2 Phosphorylation Site Controls V(D)J Recombination to Promote Genome Stability
Sae2 Promotes DNA Damage Resistance by Removing the Mre11-Xrs2-Rad50 Complex from DNA and Attenuating Rad53 Signaling
Scott Keeney, PhD
Memorial Sloan-Kettering Cancer Center
Susan Smith, PhD
NYU Langone Medical Center
Lorraine Symington, PhDColumbia University Medical Center
Eli Rothenberg, PhD
New York University School of Medicine
Agnel Sfeir, PhD
Skirball Institute of Biomolecular Medicine, New York University School of Medicine
Isabelle Schmutz, PhD
The Rockefeller University
Viji Subramanian, PhD
New York University
Jane A. Skok, PhD
New York University Langone Medical Center
Lorraine S. Symington, PhD
Columbia University Medical Center
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