
From Tumor Suppressors to Oncogenic Dynamics: The 2015 Dr. Paul Janssen Award Symposium
Wednesday, September 16, 2015
Presented By
Over the last several decades our knowledge of the molecular and genetic mechanisms of cancer development has dramatically advanced, resulting in improved therapeutics and diagnostics for treating this devastating disease. Much of the understanding of complex oncogenic processes at the genetic and molecular level would not have been possible without the groundbreaking research conducted by Dr. Bert Vogelstein over his distinguished forty-year career. Dr. Vogelstein’s pioneering work in understanding how the tumor suppressor gene TP53 promotes cancer development provided the groundwork for his discovery that cancer is a progressive, multi-step disease defined by a series of genetic alterations. This concept was further advanced when Dr. Vogelstein and his colleagues identified and characterized the Adenomatous Polyposis Coli (APC) genetic mutation in colorectal cancer, which had profound implications on how this prevalent form of cancer is diagnosed and treated. Ongoing research on the genomic landscape of cancer as well as the development of novel, cutting-edge research technologies will continue to solidify Dr. Vogelstein’s reputation as a leader in the field. For his extensive characterization of the underlying mechanisms of cancer and its resulting clinical impact, Dr. Vogelstein will receive the 2015 Dr. Paul Janssen Award for Biomedical Research.
This symposium will honor Dr. Bert Vogelstein, who will reflect on his influential work defining how cancer is studied, diagnosed, and treated, and share his vision for the future discoveries in the field. Following his Award lecture, fellow prominent scientists at the forefront of oncology research will discuss emerging concepts and technologies in both basic and clinical cancer research.
Featuring
Bert Vogelstein, MD
Johns Hopkins School of Medicine
Howard Hughes Medical Institute
Registration Pricing
This event is free, but registration is required. To attend, please click on the "Register Now" button in the grey box at the top of this page. Your registration will be complete upon receipt of a confirmation email. If you do not receive a confirmation, please contact customerservice@nyas.org for assistance.
This symposium is made possible with support from
Agenda
* Presentation titles and times are subject to change.
September 16, 2015 | |||||||
8:00 AM | Registration and Breakfast | ||||||
9:00 AM | Welcome and Introductory Remarks | ||||||
Session I: Understanding the Molecular Landscape of Cancer: From Basic Mechanisms to Clinical Intervention | |||||||
9:15 AM | 2015 Dr. Paul Janssen Award for Biomedical Research Announcement | ||||||
2015 Dr. Paul Janssen Award for Biomedical Research Lecture | |||||||
9:30 AM | Cancer Genomics & the Wars Against Cancers | ||||||
10:20 AM | Coffee and Networking Break | ||||||
Session II: Expanding the Scientific Tool Kit for Enhancing Cancer Diagnostics and TherapeuticsSession Chair: Brooke Grindlinger, PhD, The New York Academy of Sciences | |||||||
10:50 AM | Engineering T Cells: Moving Beyond Leukemia | ||||||
11:20 AM | Modular Characterization of Circulating Tumor Cells | ||||||
11:50 AM | Copper is Required for Oncogenic BRAF Signaling and Tumorigenesis | ||||||
12:20 PM | The Path to New Medicines: The K-RAS Story | ||||||
12:50 PM | Panel Discussion: The Future of Cancer Therapy
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1:15 PM | Luncheon | ||||||
2:15 PM | Adjourn |
Speakers
Christopher Counter, PhD
Duke University School of Medicine
Dr. Counter undertook his PhD with Drs. Harley and Bacchetti at McMaster University and his postdoctoral fellowship with Dr. Weinberg at the Whitehead Institute, where he studied the role of telomeres and telomerase on cell immortalization and cancer. He began an Assistant Professorship in the Department of Pharmacology & Cancer Biology at Duke University, where he exploited the ability of telomerase to immortalize human cells as an experimental platform to explore oncogenic RAS signaling, which is now a major focus of the lab. Dr. Counter is currently a Professor in the Department of Pharmacology & Cancer Biology at Duke University and has active leadership roles in the Duke Cancer Institute.
Brooke Grindlinger, PhD
The New York Academy of Sciences
Daniel A. Haber, MD, PhD
Massachusetts General Hospital
Dr. Daniel Haber is Director of the MGH Cancer Center and the Isselbacher/Schwartz Professor of Oncology at Harvard Medical School. His laboratory interests have focused on the area of cancer genetics, including the etiology of the pediatric kidney cancer Wilms tumor and genetic predisposition to breast cancer. Recently, his laboratory reported that lung cancers with activating mutations in the epidermal growth factor receptor (EGFR) are uniquely sensitive to tyrosine kinase inhibitors that target this receptor. This observation has had important implications for the genotype-directed treatment of non-small cell lung cancer, and more broadly for strategies to identify critical genetic lesions in cancers that may serve as an "Achilles heel" and be suitable for molecular targeting. In collaboration with Dr. Mehmet Toner’s laboratory, Dr. Haber’s laboratory has recently established the application of a novel microfluidic technology for quantifying and purifying circulating tumor cells from the blood of patients with various epithelial cancers. This new application has potentially profound implications for early diagnosis of cancer and for noninvasive molecular profiling of cancers during the course of therapy.
William N. Hait, MD, PhD
Janssen Research & Development
Carl June, MD
University of Pennsylvania
Carl June is the Richard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine. He is currently Director of Translational Research at the Abramson Cancer Center at the University of PA, and is an Investigator of the Abramson Family Cancer Research Institute. He is a graduate of the Naval Academy in Annapolis, and Baylor College of Medicine in Houston, 1979. He had graduate training in Immunology and malaria with Dr. Paul-Henri Lambert at the World Health Organization, Geneva, Switzerland from 1978-79, and post-doctoral training in transplantation biology with Dr. E. Donnell Thomas and Dr. John Hansen at the Fred Hutchinson Cancer Research Center in Seattle from 1983-1986. He is board certified in Internal Medicine and Medical Oncology. He founded the Immune Cell Biology Program and was head of the Department of Immunology at the Naval Medical Research Institute from 1990 to 1995 before joining the faculty of the Perelman School of Medicine in 1999. He maintains a research laboratory that studies various mechanisms of lymphocyte activation that relate to immune tolerance and adoptive immunotherapy for cancer and chronic infection. In 2014, Dr. June is considered the most influential academic scientist in the biopharmaceutical industry according to FierceBiotech.
Peter Lebowitz, MD, PhD
Janssen Research & Development
Bert Vogelstein, MD
Johns Hopkins School of Medicine
Howard Hughes Medical Institute
website
Dr. Vogelstein obtained a B.A. degree in mathematics from the University of Pennsylvania and an M.D. degree from the Johns Hopkins University School of Medicine. He performed his internship and residency in pediatrics at the Johns Hopkins Hospital and completed a post-doctoral fellowship at the National Cancer Institute. He is currently the Clayton Professor of Oncology and Pathology and Co-Director of the Ludwig Institute at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He is an Investigator of the Howard Hughes Medical Institute and a Scholar of the Lustgarten Foundation for Pancreatic Cancer Research. His work focuses on the molecular genetic basis of human tumorigenesis and its implications for the diagnosis and treatment of patients with cancer.
Additional speakers to be announced.
Sponsors
Promotional Partners
Sandra and Edward Meyer Cancer Center
This symposium is made possible with support from
Abstracts
Cancer Genomics & the Wars Against Cancers
Bert Vogelstein, MD, The Johns Hopkins University
Molecular Characterization of Circulating Tumor Cells
Daniel A. Haber, MD PhD1,3
Coauthors: Shyamala Maheswaran, PhD1, Ravi Kapur, PhD2 and Mehmet Toner, PhD2
1 Massachusetts General Hospital Cancer Center
2 Center for Bioengineering in Medicine, Harvard Medical School, Boston, Massachusetts, United States
3 Howard Hughes Medical Institute, Chevy Chase, Maryland, United States
Copper is Required for Oncogenic BRAF Signaling and Tumorigenesis
Christopher M. Counter, PhD1
Coauthors: Donita C. Brady, PhD1, Matthew S. Crowe, BS1, Michelle L. Turski, PhD1, G. Aaron Hobbs,PhD2, Xiaojie Yao, PhD3, Apirat Chaikuad, BS4, Stefan Knapp, PhD4, Kunhong Xiao, PhD3, Sharon L. Campbell, PhD2, Dennis J. Thiele, PhD1
1 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
2 Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
3 Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
4 Nuffield Department of Clinical Medicine, Target Discovery Institute and Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK
Travel & Lodging
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