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Genome Integrity Discussion Group April 2015

Genome Integrity Discussion Group April 2015

Monday, April 6, 2015

The New York Academy of Sciences

Presented By

Presented by the Genome Integrity Discussion Group at the New York Academy of Sciences.


The greater New York Metropolitan area has become a leading center for research on chromosome biology and function, as well as for research at the interface between chromosome integrity and onset and progression of malignancy. The connection between cancer and genome integrity is widely appreciated, and the concentration of excellence in this field is unparalleled anywhere in the world. The Genome Integrity meetings are designed to provide a forum for interactions between the many basic science and clinically-oriented research groups working on these issues. We feel that these interactions will not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities will be revealed.

In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions.

Genome Integrity Discussion Group meetings are organized under the leadership of Scott Keeney (Memorial Sloan Kettering Cancer Center), Susan Smith (NYU Langone Medical Center) and Lorraine Symington (Columbia University). This meeting will include a scientific symposium from 1:30 to 4:30 PM, followed by a networking reception from 4:30 to 5:30 PM.

Registration Pricing

Member (Student / Postdoc / Resident / Fellow)$0
Nonmember (Student / Postdoc / Resident / Fellow)$20

The Genome Integrity Discussion Group is proudly supported by

  • Columbia University CPS
  • Memorial Sloan Kettering Cancer Center
  • NYU Langone Medical Center
  • Rockefeller University

Mission Partner support for the Frontiers of Science program provided by   Pfizer


* Presentation titles and times are subject to change.

Monday, April 6, 2015

1:30 PM

Welcome and Introductory Remarks
Sonya Dougal, PhD, The New York Academy of Sciences
Scott Keeney, PhD, Memorial Sloan-Kettering Cancer Center

1:40 PM

Human LINE Elements: “Evolution Machines” and Their Host Interactions
Jef D. Boeke, PhD, DSc, NYU Langone Medical Center

2:10 PM

New Look at TCR
Evgeny Nudler, PhD, NYU Langone Medical Center

2:40 PM

Kenta Yamamoto, Columbia University Medical Center (Zha Lab)

2:55 PM

Networking Coffee Break

3:25 PM

ATR-Mediated Phosphorylation of FANCI Regulates Dormant Origin Firing in Response to Replication Stress
Yu-Hung Chen, PhD, NYU Langone Medical Center (Huang lab)

3:40 PM

Novel Features of the DNA Damage Response in Mycobacteria
Michael Glickman, MD, Memorial Sloan-Kettering Cancer Center

4:10 PM

Visualizing Homologous Recombination at the Single Molecule
Eric Greene, PhD, Columbia University Medical Center

4:40 PM

Closing Remarks
Scott Keeney, PhD, Memorial Sloan-Kettering Cancer Center

4:45 PM

Networking Reception

5:30 PM




Scott Keeney, PhD

Memorial Sloan-Kettering Cancer Center

Susan Smith, PhD

NYU Langone Medical Center

Lorraine Symington, PhD

Columbia University Medical Center

Sonya Dougal, PhD

The New York Academy of Sciences


Jef Boeke, PhD

NYU Langone Medical Center

Jef Boeke received his Bachelor's degree in Biochemistry from Bowdoin College and a PhD in Molecular Biology from the Rockefeller University, where he worked on the genetics of filamentous phage assembly with Peter Model and Norton Zinder. He did his postdoctoral work at MIT/Whitehead Institute on yeast genetics with Gerald Fink. He served on the faculty of Johns Hopkins University School of Medicine from 1986–2014, where he also found the High Throughput Biology Center. He is currently directing the new Institute for Systems Genetics at NYU Langone Medical Center.

Jef Boeke elucidated one of the major forms of DNA movement (transposition) in yeast cells, in which Ty1 elements move via reverse transcription of RNA. He coined the term retrotransposition to describe the process. His genetic and biochemical studies helped elucidate intricate molecular mechanisms involved in retrotransposition in eukaryotic cells. Retrotransposition formed about half of all human DNA and has been a major force in genome evolution. The Boeke laboratory has also constructed highly active synthetic retrotransposons as a probe of retrotransposition in cells and mice. Finally, Jef Boeke is leading an international team to synthesize an engineered version of the yeast genome called Sc2.0, the first synthetic eukaryotic genome.

Mike Glickman, MD

Memorial Sloan-Kettering Cancer Center

Michael Glickman MD is a Member in the Immunology Program of Sloan Kettering Institute and an Attending Physician on the Infectious Diseases Service of Memorial Hospital. Dr. Glickman studies mycobacterial DNA repair and mutagenesis with the goal of understanding the role of these pathways in mycobacterial pathogenesis and antimicrobial resistance.

Eric Greene, PhD

Columbia University Medical Center

Dr. Greene began as an Assistant Professor at Columbia University in the Department of Biochemistry and Molecular Biophysics in 2004. In 2009 Dr. Greene was appointed as an Early Career Scientist with the Howard Hughes Medical Institute and he was promoted to Associate Professor at Columbia the following year. Dr. Greene conducted postdoctoral research at the NIH in the laboratory of Dr. Kiyoshi Mizuuchi from 1999-2003, and he received his PhD in Biochemistry from Texas A&M University while working for Dr. Dorothy Shippen. Dr. Greene’s laboratory has pioneered novel technologies for studying protein DNA interactions at the single molecule level. This work relies on total internal reflection fluorescence microscopy to visualize proteins as they interact with their corresponding DNA substrates. These DNA substrates are anchored and aligned on a lipid bilayer-coated surface along the leading edges of nanofabricated metallic barriers within a microfluidic sample chamber. This substrate configuration allows us to directly visualize one the order of 100 to 1000 individual DNA molecules within a single field of view, along with any fluorescently tagged proteins bound to the DNA. This technology was developed specifically as a flexible experimental platform adaptable to the study of a wide range of protein nucleic-acid interactions.

Evgeny Nudler, PhD

NYU Langone Medical Center

Evgeny Nudler is the Howard Hughes Medical Institute Investigator and Julie Wilson Anderson Professor, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, where he has been on the faculty since 1997. He received his PhD from the Institute of Molecular Genetics, Moscow Russia, in 1995. Research in Nudler’s laboratory explores a wide range of topics on gene regulation and stress response in prokaryotic and eukaryotic species. The most recent studies from his laboratory revealed new mechanisms of bacterial resistance to antibiotics, novel roles of RNA polymerase and associated factors in genomic stability, and new factors that control cellular responses to heat and other proteotoxic damage in human cells. Honors for his research include the Searle Scholar Award, NIH Director’s Pioneer Award, NYAS Blavatnik Award, Vilcek Foundation Prize, Robertson Foundation Award and others.


For sponsorship opportunities please contact Perri Wisotsky at or 212.298.8642.

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The Genome Integrity Discussion Group is proudly supported by

  • Columbia University CPS
  • Memorial Sloan Kettering Cancer Center
  • NYU Langone Medical Center
  • Rockefeller University

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