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Genome Integrity Discussion Group February 2015

Genome Integrity Discussion Group February 2015

Monday, February 2, 2015

The New York Academy of Sciences

Presented By

Presented by the Genome Integrity Discussion Group at the New York Academy of Sciences.


The greater New York Metropolitan area has become a leading center for research on chromosome biology and function, as well as for research at the interface between chromosome integrity and onset and progression of malignancy. The connection between cancer and genome integrity is widely appreciated, and the concentration of excellence in this field is unparalleled anywhere in the world. The Genome Integrity meetings are designed to provide a forum for interactions between the many basic science and clinically-oriented research groups working on these issues. We feel that these interactions will not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities will be revealed.

In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions.

Genome Integrity Discussion Group meetings are organized under the leadership of Scott Keeney (Memorial Sloan Kettering Cancer Center), Susan Smith (NYU Langone Medical Center) and Lorraine Symington (Columbia University). This meeting will include a scientific symposium from 1:30 to 4:30 PM, followed by a networking reception from 4:30 to 5:30 PM.

Call for Student/Postdoc Presentation Abstracts: Deadline January 23rd
Two spaces are available for students and/or postdocs to present at our next meeting. Abstracts should be in CSHL format with file name: and submitted via email to Dr Scott Keeney at by January 23rd.

Registration Pricing

Member (Student / Postdoc / Resident / Fellow)$0
Nonmember (Student / Postdoc / Resident / Fellow)$20

The Genome Integrity Discussion Group is proudly supported by

  • Columbia University CPS
  • Memorial Sloan Kettering Cancer Center
  • NYU Langone Medical Center
  • Rockefeller University

Mission Partner support for the Frontiers of Science program provided by   Pfizer


* Presentation titles and times are subject to change.

February 2, 2015

1:30 PM

Welcome and Introduction
Sonya Dougal, PhD, The New York Academy of Sciences
Scott Keeney, PhD, Memorial Sloan-Kettering Cancer Center

1:40 PM

Prevalent p53 Gain-of-Function Mutants Co-Opt Epigenetic Pathways to Drive Cancer Growth
Shelley Berger, PhD, University of Pennsylvania

2:10 PM

Dynamic Regulation of Kinetochore-Microtubule Attachments by the Mps1 Kinase
Prasad Jallepalli, MD, PhD, Memorial Sloan-Kettering Cancer Center

2:40 PM

The Dynamics of Eukaryotic Replication Initiation: Origin Specificity, Licensing, and Firing at the Single-molecule Level
Daniel Duzdevich, Columbia University (Greene lab)

2:55 PM

Networking Coffee Break

3:25 PM

Rapid Epigenetic Adaptation to Uncontrolled Heterochromatin Spreading
Jiyong Wang, PhD, Columbia University (Jia lab)

3:40 PM

Chromosome Replication
Iestyn Whitehouse, PhD, Memorial Sloan-Kettering Cancer Center

4:10 PM

Long Range Communication: Interdependence of the Rad50 Hook and Globular Domain Functions
John Petrini, PhD, Memorial Sloan-Kettering Cancer Center

4:40 PM

Closing Remarks
Scott Keeney, PhD, Memorial Sloan-Kettering Cancer Center

4:45 PM

Networking Reception

5:30 PM




Scott Keeney, PhD

Memorial Sloan-Kettering Cancer Center

Susan Smith, PhD

NYU Langone Medical Center

Lorraine Symington, PhD

Columbia University Medical Center


Prasad Jallepalli, MD, PhD

Memorial Sloan-Kettering Cancer Center

Prasad Jallepalli is Member and Professor in the Molecular Biology Program at Sloan Kettering. Prior to arriving in New York, Prasad earned his A.B. degree at Harvard and his M.D. and Ph.D. degrees from Johns Hopkins. During his postdoctoral research with Bert Vogelstein, Prasad developed methods for precisely “knocking out” or otherwise modifying endogenous loci in human somatic cells. By combining these genome-editing techniques with high-resolution cell imaging, chemical genetics, and phosphoproteomics, Prasad’s lab has made significant advances in our understanding of chromosome segregation and cell division, defects in which give rise to aneuploidy, birth defects, and cancer. Current areas of interest include (1) how mitotic kinases regulate chromosome-spindle attachments; (2) how sister chromatid cohesion is established during S phase and coupled to DNA replication; and (3) how kinetochores and nuclear pore complexes transduce signals via the spindle assembly checkpoint (SAC) to control the speed and fidelity of mitosis.

Shelley Berger, PhD

University of Pennsylvania

John HJ Petrini, PhD

Memorial Sloan-Kettering Cancer Center

Dr. Petrini is the Paul A Marks Chair of Molecular Cell Biology and member of the Molecular Biology Program at SKI. He is also Professor of Medicine at WCMC. The work in Dr. Petrini's lab is focused on the DNA damage response, a network of functions comprising DNA damage signaling, DNA repair, and DNA damage dependent cell cycle regulation. His laboratory employs yeast and mice to undertake genetic, molecular biological, and biochemical analyses of the pathways in eukaryotic cells that are responsive to chromosome breaks. His laboratory has elucidated the genetic bases of several chromosome instability and cancer predisposition syndromes in humans, and have used model systems based on those diseases to understand the mechanisms that underlie the basic biological processes that are impaired in affected individuals.

Iestyn Whitehouse, PhD

Memorial Sloan-Kettering Cancer Center

Iestyn Whitehouse received his PhD from the University of Dundee in Scotland where he studied biochemical properties of ATP dependent chromatin remodeling enzymes. He then studied as a postdoc with Toshio Tsukiyama (FHCRC in Seattle) to characterize genome wide chromatin structure. He joined MSKCC in 2008 and continue to study chromatin and its relationships between gene transcription and DNA replication.


For sponsorship opportunities please contact Perri Wisotsky at or 212.298.8642.

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The Genome Integrity Discussion Group is proudly supported by

  • Columbia University CPS
  • Memorial Sloan Kettering Cancer Center
  • NYU Langone Medical Center
  • Rockefeller University

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