Genome Integrity Discussion Group

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Genome Integrity Discussion Group

Monday, December 7, 2015

The New York Academy of Sciences

Presented By

 

The connection between cancer and genome integrity is widely appreciated. Importantly, the greater New York Metropolitan area is unparalleled in the concentration of world leading research on chromosome biology and function, as well as for research at the interface between chromosome integrity and the dynamics of malignancy. The Genome Integrity Discussion Group capitalize on this concentration of excellence, providing a forum for interaction between basic- and clinically-oriented research groups working in these fields. These meetings not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities can be revealed.

In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions. At each of the meetings, two early career scientists (students or postdocs) are selected to present data.

Genome Integrity Discussion Group meetings are organized under the leadership of Lorraine Symington (Columbia University Medical Center), Scott Keeney (Memorial Sloan-Kettering Cancer Center), and Susan Smith (NYU Langone Medical Center).

Call for Student/Postdoc Presentation Abstracts: Deadline November 6th, 2015

Two abstracts will be selected for short talks by students and/or postdocs at this meeting. Please submit abstracts in CSHL format with file name: NYAS.name.doc via email to Prof Lorraine Symington at lss5@cumc.columbia.edu by November 6th, 2015.

Registration Pricing

Member$0
Member (Student / Postdoc / Resident / Fellow)$0
Nonmember (Academia)$65
Nonmember (Corporate)$75
Nonmember (Non-profit)$65
Nonmember (Student / Postdoc / Resident / Fellow)$30


The Genome Integrity Discussion Group is proudly supported by

Abcam

Columbia University Medical Center

Memorial Sloan Kettering Cancer Center

NYU Langone Medical Center

Rockefeller University

Agenda

Monday, December 7, 2015

1:30 PM

Welcome and Introductory Remarks
Caitlin McOmish, PhD, The New York Academy of Sciences
Lorraine Symington, PhD, Columbia University Medical Center

1:40 PM

Recognition and Processing of DNA Interstrand Crosslinks by Mismatch Repair Proteins
Jean Gautier, PhD, Columbia University Medical Center

2:10 PM

Consequences of Ribonucleotides in DNA
Hannah Klein, PhD, NYU School of Medicine

2:40 PM

2’-O-me or not 2’-O-me: piRNA-Guided Germline DNA Elimination During Genome Rearrangement in the Ciliate Oxytricha Trifallax
Jaspreet S. Khurana, PhD, Princeton University

2:55 PM

Networking Coffee Break

3:25 PM

DNMT3A R882 Mutations Promote Chemoresistance and Therapeutic Relapse Through Impaired DNA Damage Sensing
Olga A. Guryanova, MD, PhD, Weill Cornell Medical College

3:40 PM

A Ustilago Maydis Model of the ALT (Alternative Lengthening of Telomeres) Pathway Uncovers a Critical Role for DSB Resection Factors
Neal F. Lue, MD, PhD, Weill Cornell Medical College

4:10 PM

Mcm2-7 Sliding Promotes Replication Origin Plasticity in Eukaryotes
Dirk Remus, PhD, Memorial Sloan Kettering Cancer Center

4:40 PM

Closing Remarks
Lorraine Symington, PhD, Columbia University Medical Center

4:45 PM

Networking Reception

5:30 PM

Adjourn

Speakers

Organizers

Lorraine Symington, PhD

Columbia University Medical Center

Scott Keeney, PhD

Memorial Sloan Kettering Cancer Center

Susan Smith, PhD

NYU Langone Medical Center

Caitlin McOmish, PhD

The New York Academy of Science

Sonya Dougal, PhD

The New York Academy of Sciences

Speakers

Jean Gautier, PhD

Columbia University Medical Center

Olga A. Guryanova, MD, PhD

Weill Cornell Medical College

Despite significant advances in personalized medicine and targeted cancer therapies, most cancer treatments ultimately fail due to the development of therapeutic resistance.  Olga Guryanova aims to understand the molecular basis of drug resistance in cancer using molecular and cell biology approaches combined with genetic mouse modeling.  After graduating from Moscow State University School of Medicine, Olga trained at the Cleveland Clinic, where she identified novel signaling nodes maintaining cancer stem cell properties in aggressive brain tumors.  She is currently a postdoctoral fellow in the laboratory of Dr. Ross Levine, Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, where she is studying novel mutations in epigenetic modifier genes and their role in altered chromatin dynamics and suboptimal response to chemotherapy in acute myeloid leukemia (AML).  Olga’s career goal is to lead a research group in the field of stem cell biology of hematologic malignancies, continuing her focus on mechanistic and translational aspects of cancer research.

Jaspreet S. Khurana, PhD

Princeton University

After finishing up her Masters in Biotechnology at Jawaharlal Nehru University, New Delhi, India, Dr. Khurana applied for PhD programs in the US and chose to start graduate studies at University of Massachusetts medical school, Worcester MA in 2004. For her thesis project, Dr. Khurana decided to study the role of a class of small non-coding RNAs called piRNAs in germline development and genome evolution in Drosophila melanogaster. After completing her PhD in 2010, Dr. Khurana joined Princeton University as a postdoc with Laura Landweber. As a postdoc, she studied non-coding RNAs in programmed genome rearrangements in the ciliate, Oxytricha trifallax. Currently, Dr. Khurana is employed as an Associate Research Scientist with Laura Landweber at Columbia University, where she continues to research the same projects as before.

Hannah Klein, PhD

NYU Langone Medical Center

Dr. Kelin did undergraduate training at Cornell University, where she was first exposed to yeast genetics in the lab of Gerry Fink. She continued working with yeast for her PhD in the Department of Genetics, University of Washington, in the lab of Breck Byers.  There she used the EM to examine structures in meiotic DNA.  She also studied repetitive DNA in the EM, discovering the inverted repeat in 2 micron DNA, and classes of repeats in genomic DNA that turned out to be the Ty elements and the associated delta LTR sequences.  From there she went to Princeton University, to do a postdoc in the Department of Biochemistry with Arnold Levine, focusing on purification and study of an adenovirus DNA binding protein.  She then did a second postdoc with Tom Petes at The University of Chicago, returning to yeast and starting her studies on homologous recombination in yeast.  From there Dr. Kelin joined the Department of Biochemistry at New York University School of Medicine, continuing studies on recombination and repair in yeast.

Neal Lue, MD, PhD

Weill-Cornell Medical College

Neal F. Lue is Professor of Microbiology and Immunology at Weill Cornell Medicine and a member of the Meyer Cancer Center. He received his BS from Johns Hopkins University and his MD and PhD from Stanford University. Dr. Lue’s research focus is to understand the mechanisms of telomere maintenance and protection. His lab has utilized a variety of standard and unorthodox model systems (including e.g., Saccharmyces cerevisiae, Candida glabrata and more recently, Ustilago maydis) to investigate the fundamental protein-nucleic acid and protein-protein interactions that govern the assembly of the telomere nucleoprotein complex and the synthesis of telomeric DNA.  Two notable recent findings are: (1) the discovery of an evolutionarily conserved Stn1-Pol12 interaction that promotes telomere C-strand synthesis by primase-pol α, and (2) the characterization of a recombination-based telomere maintenance mechanism in U. maydis that closely mimic the ALT pathway in human cancers.

Dirk Remus, PhD

Memorial Sloan Kettering Cancer Center

Dr. Remus received an undergraduate degree (Diploma) from the University of Heidelberg, Germany, in 1999. From 1999 to 2003 he performed his Ph.D. studies in Prof. Mike Botchan’s lab at UC Berkeley on the biochemical characterization of the Drosophila melanogaster origin recognition complex (ORC). In 2005 he moved to London/UK as a postdoctoral fellow with Dr. John Diffley at Clare Hall Laboratories (Cancer Resarch UK, London Research Institute), focusing on the biochemical reconstitution and characterization of the Mcm2-7 loading reaction in the budding yeast, Saccharomyces cerevisiae. Since 2010 Dr. Reumus has been an Assistant Member in the Molecular Biology program at Sloan-Kettering Institute, where his lab pursues the biochemical and structural characterization of the eukaryotic DNA replication mechanism, using Saccharomyces cerevisiae as a model.

Sponsors

Promotional Partner

Nature


The Genome Integrity Discussion Group is proudly supported by

Abcam

Columbia University Medical Center

Memorial Sloan Kettering Cancer Center

NYU Langone Medical Center

Rockefeller University

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