
Tenth Cooley's Anemia Symposium
Sunday, October 18, 2015 - Thursday, October 22, 2015
Loews Chicago O'Hare Hotel
Since the Ninth Cooley's Anemia Symposium was held in 2009, all areas of thalassemia research have sustained major advances. The 2015 Symposium will bring together basic scientists, clinical investigators, and clinicians, for interactions and education. Areas of focus will include the biology of globin gene regulation and fetal hemoglobin induction; the evolving areas of stem cell transplant, gene therapy strategies, and gene editing; the biology of iron regulation and possible therapeutic interventions in the hepcidin regulatory system; and clinical issues in thalassemia treatment and imaging. Leading investigators, together with physicians involved in thalassemia care from around the world, will be featured speakers. Interactive poster sessions will allow trainees involved in all of these research areas to present their work.
Since the inaugural meeting jointly presented by the Cooley's Anemia Foundation and the Academy in 1964, this series of symposia convened at 5–6 year intervals has been the preeminent forum for convening the thalassemia research community, the pharmaceutical industry, and funding agencies dedicated to fighting this blood disorder, and the 2015 meeting will carry on this proud tradition.
Registration Pricing
| By 8/28/2015 | After 8/28/2015 | Onsite |
Member | $490 | $590 | $650 |
Student/Postdoc Member | $300 | $350 | $400 |
Nonmember (Academia/Government) | $615 | $715 | $775 |
Nonmember (Corporate) | $850 | $950 | $1,050 |
Nonmember (Non-profit) | $615 | $715 | $775 |
Nonmember (Student/Postdoc/Fellow) | $325 | $375 | $425 |
Patient | $350 | $350 | $350 |
Day Rate | $350 | $400 | $425 |
Welcome Reception ONLY | $30 | $30 | $30 |
Farewell Luncheon ONLY | $18 | $18 | $18 |
Registration fee for the entire five-day symposium includes a complimentary, one-year individual membership to the New York Academy of Sciences. Complimentary memberships are provided to non-members only and cannot be used to renew or extend existing or expiring memberships. A welcome email will be sent upon registration, which will include your membership credentials.
Proceedings will be published as a volume of Annals of the New York Academy of Sciences. Registration fee for the entire five-day symposium includes one free copy of the symposium proceedings for this event.
Please note:
- The Day Rate registration fee is available for participation on October 19, 20, or 21 only.
- Patients are welcome to attend the entire five-day symposium for a flat registration fee of $350. For more information and to register, please contact Mary Woldegiorgis, Cooley's Anemia Foundation, at mwoldegiorgis@thalassemia.org or call 212.279.8090 Ext. 208.
- Complimentary Membership and a free copy of the symposium proceedings are not included for Patient and Day Rate registration categories.
Image Credit: Wave of Hope, Wainwright Media Group.
Agenda
* Presentation titles and times are subject to change.
Day 1 — Sunday, October 18, 2015 | |
5:00 PM | Registration |
6:00 PM | Welcome Reception |
8:00 PM | Day 1 Adjourns |
Day 2 — Monday, October 19, 2015 | |
7:00 AM | Registration |
7:00 AM | Breakfast |
8:40 AM | Welcome Remarks Brooke Grindlinger, PhD, The New York Academy of Sciences |
9:15 AM | Joint Session |
9:45 AM | Keynote Address Q & A |
10:10 AM | Networking Coffee Break |
Joint Session I: Gene TherapyLocation: Avedon Ballroom C/D | |
10:30 AM | Gene Therapy for Beta-Thalassemia Major. The Memorial Sloan Kettering Experience |
10:55 AM | Outcomes of Gene Therapy for β-Thalassemia Major via Transplantation of Autologous Hematopoietic Stem Cells Transduced ex vivo with a Lentiviral βA-T87Q-Globin Vector |
11:20 AM | Toward a Gene Therapy Clinical Trial for the Treatment of Beta-Thalassemia Major at Cincinnati Children’s Hospital Medical Center |
11:45 AM | Update on Gene Therapy Clinical Trial for the Treatment of Beta-Thalassemia Major in Italy |
12:10 PM | Networking Lunch |
Concurrent Session 2A: Gene Regulation 1Location: Avedon Ballroom A/B | |
1:30 PM | Understanding the Regulation of α-globin Gene Expression and its Implication for the Treatment of β-Thalassemia |
1:55 PM | Humanized Mouse Models of Cooley’s Anemia |
2:20 PM | Modulation of the Pathways that Control HbF Synthesis |
2:45 PM | Long Range Enhancer Control of Beta-globin Genes |
Concurrent Session 2B: Clinical Management 1Location: Avedon Ballroom C/D | |
1:30 PM | Nutrition for Patients with Thalassemia |
2:00 PM | An ‘Aging’ Population of Adults with Transfusion-dependent Thalassemia (TDT) |
2:30 PM | Diagnostic Challenges: Carrier vs. Thalassemia Intermedia |
3:10 PM | Comfort Break |
Concurrent Session 3A: Gene Regulation 2Location: Avedon Ballroom A/B | |
3:30 PM | Regulation of HbF Synthesis |
4:00 PM | CRISPR/Cas-enhanced Gene Replacement for Sickle Cell Disease |
4:30 PM | The LRF/ZBTB7A Transcription Factor Regulates BCL11A-independent Globin Switching |
Concurrent Session 3B: Clinical Management 2Location: Avedon Ballroom C/D | |
3:30 PM | Diverse Hematological Phenotypes and Screening for β-Thalassemia Carriers |
3:55 PM | Cardiac Complications in Thalassemia |
4:20 PM | When to Transfuse in Patients with Non-transfusion–dependent Thalassemia (NTDT) |
4:45 PM | Assessment and Treatment of Pain in Thalassemia |
5:10 PM | Day 2 Adjourns |
Day 3 — Tuesday, October 20, 2015 | |
6:30 AM | Breakfast |
6:30 AM | Poster Session Set-up |
Concurrent Breakfast Sessions | |
7:00 AM | SESSION A |
Studies of Fetal Hemoglobin Regulation in Cultured Human Erythroblasts | |
New Insights of Ineffective Erythropoiesis in β-Thalassemia: Therapeutic Implications | |
7:00 AM | SESSION B |
Focus on Adherence: Facilitators and Barriers | |
Self-efficacy and Adherence with Iron Chelation Therapies: Motivational Interviewing Interventions | |
8:00 AM | Comfort Break |
Joint Session: Clinical KeynoteLocation: Avedon Ballroom C/D | |
8:45 AM | Clinical Keynote Address: Clinical Features of Thalassemia Syndromes in 2015 |
9:30 AM | Keynote Address Q & A |
9:45 AM | Networking Coffee Break |
Joint Session 4: ChelationLocation: Avedon Ballroom C/D | |
10:15 AM | How Do We Choose Target Iron Levels? |
10:45 AM | Evolving Concepts in Safety, Efficacy, and Side Effects of Iron Chelators |
11:15 AM | Current Recommendations for Chelation Therapy |
11:45 PM | Networking Lunch |
11:45 PM | Mentoring Lunch for Women, Underrepresented Minorities, and Early Career Investigators |
Joint Session 5: ImagingLocation: Avedon Ballroom C/D | |
1:20 PM | Imaging Assessment of Organs in Cooley’s Anemia with an Emphasis on MRI |
1:50 PM | Evolving MRI Techniques and Application to Iron Detection |
2:20 PM | Expanding our Understanding of Organ Iron Overload — Evidence for Broader Use of MRI in Iron Detection |
2:50 PM | Networking Coffee Break |
Joint Session 6: Iron Regulation/MetabolismLocation: Avedon Ballroom C/D | |
3:10 PM | Iron-related Pathways Controlling Hepcidin Expression |
3:40 PM | Non-liver Regulation of Iron Metabolism: Kidney and Heart |
4:10 PM | Clinical Disorders of Iron Metabolism: New Insights into Diseases of Hepcidin Dysregulation |
4:50 PM | Poster Session |
6:30 PM | Day 3 Adjourns (Poster Session posters removed) |
Day 4 — Wednesday, October 21, 2015 | |
7:00 AM | Breakfast |
7:00 AM | Poster Session Set-up Location: Artist Foyer |
Joint Breakfast SessionLocation: Avedon Ballroom C/D | |
7:30 AM | Special Clinical Focus: Morbidities in Non-transfusion–dependent Thalassemia (NTDT) |
8:30 AM | Comfort Break |
Joint Session 7: Clinical Management 3Location: Avedon Ballroom C/D | |
9:00 AM | Iron Deficiency, Infection, Inflammation, and Hepcidin Regulation |
9:25 AM | Age of Transfused Blood and Blood-borne Infections |
9:50 AM | Management of Thalassemia-associated Osteoporosis |
10:15 AM | Hepatitis C Treatment Advances |
10:40 AM | Nonmyeloablative Transplantation in Adults with Severe Sickle Cell Disease |
11:05 AM | Networking Coffee Break |
Joint Session: Best of Oral Poster PresentationsLocation: Avedon Ballroom C/D | |
11:30 AM | Clinical-scale Genome Editing of the Human BCL11A Erythroid Enhancer for Treatment of β-Thalassemia |
11:45 AM | Amelioration of Murine Sickle Cell Disease by Non-Ablative Conditioning and Gamma-globin Gene–corrected Bone Marrow Cells |
12:00 PM | Rescue of Humanized Cooley’s Anemia Mice from Lethal Anemia by a Single Point Mutation in the ɣ-Globin Gene Promoter |
Patient Presentation | |
12:15 PM | Pioneering Gene Therapy – A Patient’s Perspective |
12:30 PM | Networking Lunch |
12:30 PM | Poster Session Authors stationed at posters from 12:30 PM–1:30 PM |
Joint Session 8: TransplantLocation: Avedon Ballroom C/D | |
1:30 PM | Management of Iron Overload Before, During, and After Successful Transplantation |
2:00 PM | Unrelated Donor Transplantation Using Reduced Intensity Conditioning in Children with Thalassemia Major |
2:30 PM | Comfort Break |
Joint Session 9: End Organ DamageLocation: Avedon Ballroom C/D | |
3:00 PM | Pulmonary Hypertension in Thalassemia |
3:25 PM | Renal Aspects of Thalassemia |
3:50 PM | Hepatocellular Carcinoma in Thalassemia. An Update of the Italian Registry |
4:15 PM | Iron and Cancer |
4:40 PM | Day 4 Adjourns (Poster Session posters removed) |
Day 5 — Thursday, October 22, 2015 | |
8:00 AM | Breakfast |
Joint Session 10: Emerging TherapiesLocation: Avedon Ballroom C/D | |
9:00 AM | Luspatercept (ACE-536) Trial Update |
9:25 AM | Using Murine Thalassemia Models to Evaluate Novel Therapies |
9:50 AM | Genome Editing Strategies to Induce HbF for the Beta-Hemoglobinopathies |
10:15 AM | Hepcidin Regulators |
10:40 AM | Networking Coffee Break |
Summary and Closing RemarksLocation: Avedon Ballroom C/D | |
11:00 AM | Symposium Summary |
11:30 AM | The Bright Future and the Conundrum of Beta Thalassemia |
11:50 AM | Concluding Remarks |
12:00 PM | Farewell Luncheon |
1:00 PM | Symposium Concludes |
Speakers
Chair, Scientific Organizing Committee
Ellis Neufeld, MD, PhD
Boston Children’s Hospital/Harvard Medical School
Organizers
Emanuele Angelucci, MD
Cancer Hospital "Armando Businco" Cagliari
Maria Domenica Cappellini, MD
University of Milan
Gina Cioffi, JD
Cooley's Anemia Foundation
Suthat Fucharoen, MD
Mahidol University Salaya Campus
Thalassemia Research Center, Thailand Institute of Science and Technology
Janet L. Kwiatkowski, MD, MSCE
Children’s Hospital of Philadelphia
Perelman School of Medicine, University of Pennsylvania
Antonio Piga, MD
Torino University
Stefano Rivella, PhD
Children's Hospital of Philadelphia
Ali Taher, MD, PhD, FRCP
American University of Beirut Medical Center
Alexis Thompson, MD, MPH
Northwestern University Feinberg School of Medicine
Ann and Robert H. Lurie Children's Hospital of Chicago
Vip Viprakasit, MD, PhD
Faculty of Medicine Siriraj Hospital, Mahidol University
Speakers and Session Chairs
Emanuele Angelucci, MD
Cancer Hospital "Armando Businco," Cagliari
Jodie L. Babitt, MD
Massachusetts General Hospital
Jonathan M. Barasch, MD, PhD
Columbia University
Daniel E. Bauer, MD, PhD
Boston Children's Hospital
Dana-Farber Cancer Institute
Harvard Medical School
Sunil Bhandari, MBChB, MRCP, FRCP, PhD, M Clin Ed, FHEA
Hull and East Yorkshire Hospitals NHS Trust and Hull York Medical School
James Bieker, PhD
Mount Sinai School of Medicine
Farid Boulad, MD
Memorial Sloan-Kettering Cancer Center
Caterina Borgna-Pignatti, MD
University of Ferrara
Maria Domenica Cappellini, MD
University of Milan
Marina Cavazzana-Calvo, MD, PhD
Hospital Necker, University Paris Descartes
David H.K. Chui, MD
Boston University School of Medicine
Thomas D. Coates, MD
Childrens Hospital Los Angeles, University of Southern California Keck School of Medicine
Alan R. Cohen, MD
The Children's Hospital of Philadelphia
Ann Dean, PhD
National Institutes of Health
David Dinan, MD
Nemours Children’s Hospital
Alexander (Hal) Drakesmith, PhD
Radcliffe Department of Medicine, University of Oxford
Kathleen Durst, MA, LCSW
Cooley's Anemia Foundation
Giuliana Ferrari, PhD
San Raffaele-Telethon Institute for Gene Therapy
Steven Flamm, MD
Northwestern Medical Center
Mark D. Fleming, MD, DPhil
Boston Children's Hospital
Suthat Fucharoen, MD
Mahidol University
Ellen B. Fung, PhD, RD
UCSF Benioff Children's Hospital Oakland
Andrea Giusti, MD
Galliera Hospital
Brooke Grindlinger, PhD
The New York Academy of Sciences
Olivier Hermine, MD, PhD
Hospital Necker, University Paris Descartes
Doug Higgs, FRS
University of Oxford
Eldad Arie Hod, MD
Columbia University
Janet L. Kwiatkowski, MD, MSCE
The Children's Hospital of Philadelphia
Ashutosh Lal, MD
University of California San Francisco Benioff Children's Hospital Oakland
Stephen A. Liebhaber, MD
Perelman School of Medicine at the University of Pennsylvania
Roberto Machado, MD
University of Illinois College of Medicine
Takahiro Maeda, MD, PhD
Brigham and Women's Hospital
Punam Malik, MD
Cincinnati Children’s Hospital
Jeffery L. Miller, MD
National Institute of Diabetes and Digestive and Kidney Diseases
David G. Nathan, MD
Dana-Farber Cancer Institute
Elizabeth (Ella) Nemeth, MD
University of California, Los Angeles
Ellis Neufeld, MD, PhD
Boston Children's Hospital
Arthur Nienhuis, MD
St. Jude Children's Research Hospital
Stuart H. Orkin, MD
Boston Children's Hospital and Dana Farber Cancer Institute
Dudley Pennell, MD
Imperial College London
Antonio Piga, MD
Torino University
John Porter, MA, MD, FRCP, FRC(Path)
University College London Hospitals
Scott Reeder, MD, PhD
University of Wisconsin School of Medicine and Public Health
Stefano Rivella, PhD
Children's Hospital of Philadelphia
Thomas M. Ryan, PhD
The University of Alabama at Birmingham
Vijay Sankaran, MD, PhD
Boston Children's Hospital
Dana-Farber Cancer Institute
Shalini Shenoy, MD
St. Louis Children's Hospital
Ali Taher, MD, PhD, FRCP
American University of Beirut Medical Center
Swee Lay Thein, MD
National Institutes of Health (as of March 2015)
Alexis Thompson, MD, MPH
Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Ann and Robert H. Lurie Children's Hospital of Chicago
John F. Tisdale, MD
National Heart, Lung, and Blood Institute
Suzy V. Torti, PhD
University of Connecticut Health Center
Tim M. Townes, PhD
School of Medicine, The University of Alabama at Birmingham
Marsha J. Treadwell, PhD
Children's Hospital Oakland
Elliot Vichinsky, MD
Children's Hospital Oakland Research Institute
Anthony J. Viola, CPA
Cooley's Anemia Foundation
Vip Viprakasit, MD, PhD
Faculty of Medicine Siriraj Hospital, Mahidol University
Mark Walters, MD
Children's Hospital and Research Center Oakland
Richard Ward, MD
Toronto General Hospital
John C. Wood, MD, PhD
Children's Hospital Los Angeles
Coordinator
Jenna O'Neil
Boston Children's Hospital
Sponsors
For sponsorship opportunities please contact:
Gina Cioffi, JD | Brooke Grindlinger, PhD |
Platinum Sponsor
Silver Sponsors
Bronze Sponsors
Academy Friends
Grant Support
Funding for this conference was made possible (in part) by 1R13HL129737-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Promotional Partners
American Society for Blood & Marrow Transplantation
American Society of Hematology (ASH)
The American Society of Gene & Cell Therapy
Center for International Blood and Marrow Transplant Research (CIBMTR)