The Addicted Brain and New Treatment Frontiers: Sixth Annual Aspen Brain Forum

The Addicted Brain and New Treatment Frontiers: Sixth Annual Aspen Brain Forum

Wednesday, May 18, 2016 - Friday, May 20, 2016

The New York Academy of Sciences

Presented By

The Aspen Brain Forum Foundation

Science Translational Medicine

The New York Academy of Sciences

 

Substance and alcohol-use disorders — characterized by continued, compulsive, stimulus-seeking behaviors despite serious negative physical, emotional, and social consequences — impose significant human health, economic, and legal burdens on society. Although research suggests that addiction is strongly related to neurobiological changes in the brain, implementation of neuroscience-based therapeutic strategies to address addiction is a relatively nascent development. As such, patients in need of treatment for addiction may not be receiving short- and long-term care that considers neurobiological, molecular, and/or genetic aspects of addiction.

This 2.5-day conference will convene a multidisciplinary group of researchers, clinicians, government and industry representatives, and non-profit leaders to explore the latest scientific advances in the field of addiction, with the end goal of improving treatment. The event will feature sessions and presentations focused on the neural circuitry of addiction, neuroplasticity, the susceptibility of the developing adolescent brain, and new horizons for treatment strategies, and will draw on speakers from the fields of neuroscience, behavioral physiology/medicine, cognitive and clinical neuroimaging, pharmacogenetics, neurobiology, psychology, epigenetics, genetic medicine, criminal justice, policy, and economics.  The conference will conclude with a session dedicated to improving social and government policies so that neuroscience research can be more effectively applied to addiction treatment.

The conference will begin with an evening public lecture and panel discussion, followed by a networking receptionScientific sessions over the next two days will feature keynote addresses from National Institute on Drug Abuse Director, Nora D. Volkow, MD and National Institute on Alcohol Abuse and Alcoholism Director, George F. Koob, PhD, along with two interactive poster sessions, invited lectures, and short Hot Topic presentations selected from submitted abstracts.

Public Lecture Information

Registration for this conference includes free access to the Public Lecture, Arrested Development: The Teenage Brain and Substance Abuse, and Reception on Wednesday, May 18, 2016. 

Registration Pricing

By 4/18/2016After 4/18/2016Onsite
Member$295$350$395
Student/Postdoc Member$195$250$295
Nonmember (Academia)$395$450$495
Nonmember (Corporate)$495$595$650
Nonmember (Non-profit)$395$450$495
Nonmember (Student/Postdoc/Fellow)$220$275$320

Registration includes a complimentary, one-year membership to the New York Academy of Sciences. Complimentary memberships are provided to non-members only and cannot be used to renew or extend existing or expiring memberships. A welcome email will be sent upon registration which will include your membership credentials.

Webinar Pricing

This event will also be broadcast as a webinar; registration is required.

Please note: Transmission of presentations via the webinar is subject to individual consent by the speakers. Therefore, we cannot guarantee that every speaker's presentation will be broadcast in full via the webinar. To access all speakers' presentations in full, we invite you to attend the live event in New York City where possible.

5/19/20165/20/20165/19 – 5/20/2016
Member$75$75$145
Student/Postdoc Member$40$40$90
Nonmember (Academia)$100$100$195
Nonmember (Corporate)$125$125$245
Nonmember (Non-profit)$100$100$195
Nonmember (Student/Postdoc/Fellow)$50$50$110

Agenda

* Presentation titles and times are subject to change.


Day 1: Wednesday May 18, 2016 – Public Lecture

To register solely to attend Day 1, please visit www.nyas.org/TeenAddiction

5:00 PM

Registration

5:45 PM

Welcome and Introductory Remarks
Includes special Introductory Remarks from New York City First Lady Chirlane McCray (via video address)

6:00 PM

Public Lecture
Arrested Development: The Teenage Brain and Substance Abuse

Moderator:Claudia Wallis, Managing Editor, Scientific American Mind
Panelists:Honorable Gregory P. Canova, JD, King County Superior Court (2000–2015); King County Drug Court (2012–2015)
Cheryl Healton, DrPH, MPA, College of Global Public Health, New York University
Nora D. Volkow, MD, National Institute on Drug Abuse, U.S. National Institutes of Health
Jeremy Waletzky, MD, The George Washington University

7:00 PM

Reception

7:45 PM

Public Lecture Adjourns

Day 2: Thursday, May 19, 2016

7:30 AM

Registration, Continental Breakfast, and Poster Session Setup

8:30 AM

Opening Remarks

8:45 AM

Keynote Address
Disease of Addiction: Significance to Brain Development, Function, and Behavior
Nora D. Volkow, MD, National Institute on Drug Abuse, U.S. National Institutes of Health


Session I: Mechanisms of Neuroplasticity in Addiction

Session Chair:
George F. Koob, PhD, National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health

9:30 AM

Synaptic Plasticity and Circuitry Mediating Relapse to Drug Use
Peter W. Kalivas, PhD, Medical University of South Carolina

10:00 AM

The Neural Basis of Learning Mechanisms Underlying Addiction
Barry J. Everitt, ScD, University of Cambridge

10:30 AM

Deconstructing Aversive Brain Networks that Drive Addiction
Thomas L. Kash, PhD, University of North Carolina School of Medicine

11:00 AM

Networking Coffee Break

11:30 AM

Tolerance and Dependence: Neural Adaptations to Chronic Drug and Alcohol Exposure
David M. Lovinger, PhD, National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health

12:00 PM

Optical De(Re)construction of Neural Systems: Applications to Research on Addiction Neuroscience
Michael R. Bruchas, PhD, Washington University School of Medicine

12:30 PM

Networking Lunch

1:00 PM

Early Career Investigator Mentoring Workshop
Recommended for Graduate Students, Post-doctoral Fellows, and Junior Faculty

Editor's Guide to Writing and Publishing Your Paper
Brooke Grindlinger, PhD, The New York Academy of Sciences
Former Editor, The Journal of Clinical Investigation

In this 45-minute workshop participants will gain an inside look into the editorial review process and how to best present the results of their work for publication.


Session II: Adolescent Brain Development and Susceptibility In Addiction

Session Chair:
David R. Gastfriend, MD, Treatment Research Institute; American Society of Addiction Medicine

2:00 PM

Transcriptional and Epigenetic Mechanisms of Addiction
Eric J. Nestler, MD, PhD, Icahn School of Medicine at Mount Sinai Hospital

2:30 PM

Alcohol's Dynamic Effect on Neurodevelopment
Susan F. Tapert, PhD, University of California San Diego; Veterans Affairs San Diego Healthcare System

3:00 PM

Cannabis and Neurodevelopment in Adolescence
Staci A. Gruber, PhD, McLean Hospital, Harvard Medical School
* Presenter slides will not be included as part of the Webinar broadcast

3:30 PM

Networking Coffee Break

4:00 PM

Neurobiological Underpinnings of Adolescent Drug Abuse and Implications for Prevention and Treatment
Diana H. Fishbein, PhD and Emma J. Rose, PhD, The Pennsylvania State University

4:30 PM

Electronic Cigarettes and Adolescents
Thomas Eissenberg, PhD, Virginia Commonwealth University


Session III: Hot Topic Talks from Submitted Abstracts

Session Chair:
Joseph Dial, The Aspen Brain Forum Foundation

5:00 PM

Neural Predictors of Initiating Alcohol Use during Adolescence
Lindsay M. Squeglia, PhD, Medical University of South Carolina

5:15 PM

Perceived Susceptibility to Nicotine Addiction as a Predictor of E-cigarette Use
Olusegun Owotomo, MD, MPH, University of Texas at Austin

5:30 PM

Networking Reception and Poster Session

7:00 PM

Conference Day 2 Adjourns

Day 3: Friday, May 20, 2016

7:30 AM

Continental Breakfast

8:15 AM

Keynote Address
Dark Side of Addiction: Alcohol Abuse and the Stress System
George F. Koob, PhD, National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health


Session IV: New Horizons for Treatment Strategies

Session Chair:
Orla M. Smith, PhD, Science Translational Medicine

9:00 AM

Optogenetically-inspired Deep Brain Stimulation Reverses Cocaine-evoked Synaptic Plasticity
Meaghan Creed, PhD, University of Geneva

9:30 AM

Immune-based Therapies for Substance Dependence
Ronald G. Crystal, MD, Weill Cornell Medical College

10:00 AM

Networking Coffee Break

10:30 AM

Pharmacologic Approaches to Resolving the Opioid Epidemic
David R. Gastfriend, MD, Treatment Research Institute; American Society of Addiction Medicine

11:00 AM

Personalized Treatment Using Genetics: An Illustration from Tobacco
Rachel F. Tyndale, PhD, Centre for Addiction and Mental Health; University of Toronto


Session V: Hot Topic Talks from Submitted Abstracts

Session Chair:
Rachel F. Tyndale, PhD, Centre for Addiction and Mental Health; University of Toronto

11:30 AM

Temporal Discounting as an Individualized Computational Marker of Treatment Efficacy for Opioid Use Disorder
Silvia Lopez-Guzman, MD, New York University

11:45 AM

Accumbens nNOS Interneurons Underlie Cued Relapse to Cocaine Seeking
Michael D. Scofield, PhD, Medical University of South Carolina

12:00 PM

Networking Lunch

12:30 PM

Poster Session


Session VI: Neuroscience to Action: What's Wrong and What Can We Fix?

Session Chair:
Peter W. Kalivas, PhD, Medical University of South Carolina

1:30 PM

State of the Science of Cannabis Research: Update from the NIH Marijuana Summit, March, 2016
Susan R. B. Weiss, PhD, National Institute on Drug Abuse, U.S. National Institutes of Health

2:00 PM

Translational Overview of the Neurobiology of Addiction and Societal Implications
Yasmin Hurd, PhD, Icahn School of Medicine at Mount Sinai Hospital

2:30 PM

Neurobiology of Decision-making and Willful Choice in the Context of Addiction
P. Read Montague, PhD, Virginia Polytechnic Institute and State University; University College London

3:00 PM

Networking Coffee Break

3:30 PM

Optimizing Public Health and Safety in the Face of Addiction
Mark A. R. Kleiman, PhD, New York University, Marron Institute of Urban Management

4:00 PM

Healthcare Systems and Policy in the Management of Care for Addiction
The Peter G. Dodge Foundation Lecture
A. Thomas McLellan, PhD, Treatment Research Institute

4:30 PM

Introduction by Susan R. B. Weiss, PhD
National Institute on Drug Abuse, US National Institutes of Health

Closing Lecture Keynote Address: My Journey—Making Mental Health Essential Health
The Honorable Patrick J. Kennedy, Former United States Representative, Rhode Island; Co-Founder, One Mind; and Founder, Kennedy Forum

5:00 PM

Closing Remarks

5:15 PM

Conference Concludes

Keynote Speakers

The Honorable Patrick J. Kennedy

Former United States Representative, Rhode Island; Co-Founder, One Mind; and Founder, Kennedy Forum
website

George F. Koob, PhD

National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health
website

Nora D. Volkow, MD

National Institute on Drug Abuse, U.S. National Institutes of Health
website
Any reference to NIDA or the NIH, or Dr. Volkow, should not be viewed as an endorsement of The New York Academy of Sciences, its products, or services.

Organizers

Melanie Brickman Stynes, PhD, MSc

The New York Academy of Sciences
website

Joseph Dial

Chair, Scientific Advisory Board, The Aspen Brain Forum Foundation

David R. Gastfriend, MD

Treatment Research Institute; American Society of Addiction Medicine
website

Staci A. Gruber, PhD

McLean Hospital, Harvard Medical School
website

Peter W. Kalivas, PhD

Medical University of South Carolina
website

Katrina L. Kelner, PhD

Science Translational Medicine
website

George F. Koob, PhD

National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health
website

Orla M. Smith, PhD

Science Translational Medicine
website

Erick T. Tatro, PhD

The New York Academy of Sciences

Rachel F. Tyndale, PhD

Centre for Addiction and Mental Health; University of Toronto

Nora D. Volkow, MD

National Institute on Drug Abuse, U.S. National Institutes of Health
website
Any reference to NIDA or the NIH, or Dr. Volkow, should not be viewed as an endorsement of The New York Academy of Sciences, its products, or services.

Additional Confirmed Speakers

Michael R. Bruchas, PhD

Washington University School of Medicine
website

Honorable Gregory P. Canova, JD

King County Superior Court (2000–2015); King County Drug Court (2012–2015)

Meaghan Creed, PhD

University of Geneva

Ronald G. Crystal, MD

Weill Cornell Medical College
website

Thomas Eissenberg, PhD

Virginia Commonwealth University
website

Barry J. Everitt, ScD

University of Cambridge
website

Diana H. Fishbein, PhD

The Pennsylvania State University
website

Cheryl Healton, DrPH, MPA

College of Global Public Health, New York University
website

Yasmin Hurd, PhD

Icahn School of Medicine at Mount Sinai Hospital
website

Thomas L. Kash, PhD

University of North Carolina School of Medicine
website

Mark A. R. Kleiman, PhD

New York University, Marron Institute of Urban Management

Silvia Lopez-Guzman, MD

New York University

David M. Lovinger, PhD

National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health
website

A. Thomas McLellan, PhD

Treatment Research Institute
website

P. Read Montague, PhD

Virginia Polytechnic Institute and State University; University College London
website

Eric J. Nestler, MD, PhD

Icahn School of Medicine at Mount Sinai Hospital
website

Olusegun Owotomo, MD, MPH

University of Texas at Austin

Emma J. Rose, PhD

The Pennsylvania State University

Michael D. Scofield, PhD

Medical University of South Carolina

Lindsay M. Squeglia, PhD

Medical University of South Carolina

Susan F. Tapert, PhD

University of California San Diego; Veterans Affairs San Diego Healthcare System
website

Jeremy Waletzky, MD

The George Washington University

Claudia Wallis

Scientific American Mind
website

Susan R. B. Weiss, PhD

National Institute on Drug Abuse, U.S. National Institutes of Health
website

Sponsors

For sponsorship opportunities please contact Erick T. Tatro at etatro@nyas.org or 212.298.8648.

Bronze Sponsor

Braeburn Pharmaceuticals

Academy Friends

Addiction Technology Transfer Centers

Gosnold on Cape Cod

The Newport Academy

The Peter G. Dodge Foundation

Grant Support

Indivior Inc. has provided unrestricted funding to support the program.

This event was supported by the National Institute On Drug Abuse of the National Institutes of Health under Award Number R13DA041813. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Media Partner

Promotional Partners

8th Annual Mississippi Addiction Conference

Alcohol

Alcoholism and Drug Addiction

Addictive Behaviors

Addictive Behaviors Reports

Botec Analysis Corporation

College on Problems of Drug Dependence

The Dana Foundation

Greater NYC Chapter of the Society for Neuroscience

International Journal of Drug Policy

International Society of Addiction Medicine

Journal of Substance Abuse Treatment

NAADAC – The Association for Addiction Professionals

National Council on Alcoholism and Drug Dependence, Inc.

Neuropsychopharmacology


Presented by

Abstracts

Day 1 — May 18, 2016

Arrested Development: The Teenage Brain and Substance Abuse

Although rates of adolescent alcohol and substance use have declined in recent years, both remain a pervasive problem in the United States. Underlying youth addiction is a complex network of neurological, psychological, social, and political factors that interplay with one another. Changes in the brain’s inhibition and reward centers that promote the transition from voluntary to compulsive drug use, psychosocial influences that shape both the process and treatment of addiction, personal family perspectives, and the therapeutic role of the drug courts will be explored in this evening event by a panel of experts in neurobiology, psychology, and criminal justice.

Travel & Lodging

Our Location

The New York Academy of Sciences

7 World Trade Center
250 Greenwich Street, 40th floor
New York, NY 10007-2157
212.298.8600

Directions to the Academy

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