Genome Integrity Discussion Group December 2017
Monday, December 4, 2017, 1:30 PM - 4:30 PM
The New York Academy of Sciences, 7 World Trade Center, 250 Greenwich St Fl 40, New York, USA
The New York Academy of Sciences
The connection between cancer and genome integrity is widely appreciated. Importantly, the greater New York Metropolitan area is unparalleled in the concentration of world leading research on chromosome biology and function, as well as for research at the interface between chromosome integrity and the dynamics of malignancy. The Genome Integrity Discussion Group capitalize on this concentration of excellence, providing a forum for interaction between basic- and clinically-oriented research groups working in these fields. These meetings not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities can be revealed.
In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions. At each of the meetings, two early career scientists (students or postdocs) are selected to present data.
Genome Integrity Discussion Group meetings are organized under the leadership of Scott Keeney (Memorial Sloan Kettering Cancer Center), Susan Smith (NYU Langone Medical Center), and Lorraine Symington (Columbia University Irving Medical Center).
Call for Student/Postdoc Presentation Abstracts: Deadline November 3, 2017
Two abstracts will be selected for short talks by students/postdocs. Please submit abstracts in CSHL format with file name NYAS.name.doc via email to Professor Keeney at firstname.lastname@example.org by November 3, 2017, for consideration.
December 04, 2017
Welcome and Introductory Remarks
Phosphorylation-mediated clearance of amyloid-like assemblies in meiosis
Mechanisms of Pol ε function revealed by modeling cancer-associated mutations in yeast
Rad51 filaments are required for DNA damage-induced chromosomal mobility
CST counters resection at double-strand breaks
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Type III CRISPR-Cas: Dissecting a Multi-Pronged Attack One Molecule at A Time