Advances in Translational Models to Study Fibrosis

Advances in Translational Models to Study Fibrosis

Tuesday, April 17, 2018, 9:00 AM - 6:00 PM

The New York Academy of Sciences, 7 World Trade Center, 250 Greenwich St Fl 40, New York

Fibrosis is a common pathology in many chronic diseases and is often associated with disease progression. Many extracellular matrix macromolecules, as well as their regulators and modifiers have been identified as potential disease targets or biomarkers by extensive studies in numerous preclinical animal models of fibrosis. However, therapeutics development depends on in vitro experimental systems that model pathological processes in order to build assays for screening, mechanistic characterization and target disease link evaluation. In vitro fibrosis experimental systems have been limited, but a better understanding of shared pathways and the distinctions that lead to fibrosis in different organs is now emerging from technical advances such as proteomics, RNAseq, laser capture microdissection and the availability of clinical materials. The advent of engineered substrata with defined biomechanical properties, the use of stem cells and capabilities for genetic modification have also contributed to the design of increasingly sophisticated in vitro models of fibrosis. When coupled with co-culture and organoid technologies, these advances enable modeling of cell and tissue interactions in normal and fibrotic settings. This symposium will review what is known about the cell and molecular biology of fibrosis and reparative healing, discuss current model systems, and consider the challenges and opportunities for future innovation.

Call for Abstracts

Abstract submissions are invited for a poster session. For complete submission instructions, please visit our online portal. The deadline for abstract submission is  February 20, 2018.

Registration

Member
$60
Nonmember Academia, Faculty, etc.
$105
Nonmember Corporate, Other
$160
Nonmember Not for Profit
$105
Nonmember Student, Undergrad, Grad, Fellow
$70
Member Student, Post-Doc, Fellow
$25

Organizers

Advances in Translational Models to Study Fibrosis
Scott MacDonnell, PhD, Regeneron
Advances in Translational Models to Study Fibrosis
Ignacio Juncadella, PhD, Boehringer Ingelheim
Advances in Translational Models to Study Fibrosis
Julie Hawkins, PhD, Boehringer Ingelheim
Advances in Translational Models to Study Fibrosis
John Hambor, PhD, Boehringer Ingelheim
Advances in Translational Models to Study Fibrosis
Sonya Dougal, PhD, The New York Academy of Sciences

Speakers

Advances in Translational Models to Study Fibrosis
Florian Rieder, MD, Cleveland Clinic
Advances in Translational Models to Study Fibrosis
Joseph Bonventre, MD, PhD, Harvard Medical School
Advances in Translational Models to Study Fibrosis
Eric White, MD, University of Michigan Medical School
Advances in Translational Models to Study Fibrosis
Scott MacDonnell, PhD, Regeneron
Advances in Translational Models to Study Fibrosis
Katalin Susztak, MD, PhD, Perelmann School of Medicine University of Pennsylvania
Advances in Translational Models to Study Fibrosis
Robert Lafyatis, MD, University of Pittsburgh
Advances in Translational Models to Study Fibrosis
Christine Garcia, MD, PhD, University of Texas, Southwestern Medical Center
Advances in Translational Models to Study Fibrosis
Galina Bogatkevich, MD, PhD, Medical University of South Carolina​

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