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WEBINAR
Alzheimer’s Disease Therapeutics: Alternatives to Amyloid
Tuesday, December 11, 2018, 8:30 AM - 6:00 PM EST
The New York Academy of Sciences, 7 World Trade Center, 250 Greenwich St Fl 40, New York
For years, the Alzheimer’s research community has been focused on amyloid as the key to curing this devastating disease. However, there are currently only four drugs approved to treat the symptoms of Alzheimer’s disease, and no new therapies have been approved in the last 15 years. Moreover, multiple clinical trials have recently failed, including several Phase III trials that targeted amyloid with antibodies. As a result, there is burgeoning interest in identifying alternative drug targets: over half of ongoing preclinical research in Alzheimer’s disease now focuses on pathways other than amyloid and tau.
This one-day symposium will highlight emerging mechanisms driving Alzheimer's disease — including mitochondrial factors, the vascular system, infections, and autophagy — as well as discuss strategies to identify new therapeutic targets.
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Tuesday
December 11, 2018
Breakfast and Registration
Introduction and Welcome Remarks
Speakers
Overview of the Current State of Alzheimer’s Disease Therapeutics
Speaker
Alzheimer's Disease: The Role of Genes, Glia and Germs
Speaker
HDAC Dysregulation Assessed by PET Imaging in Alzheimer's Disease
Speaker
Networking Coffee Break
Mitochondria-Targeted Therapeutics for Alzheimer’s Disease
Speaker
Precision Medicine Approach for Treating Neurological Diseases via Sigma-1 Receptor Activation
Speaker
Blood-Derived Plasminogen Drives Brain Inflammation and Plaque Deposition in a Mouse Model of Alzheimer’s Disease
Speaker
Clinical Evaluation of Allogeneic Longeveron Mesenchymal Stem Cells for Mild Alzheimer’s Disease
Speaker
Genetic Rescue of Mitochondrial Calcium Efflux in Alzheimer’s Disease Preserves Mitochondrial Function and Protects Against Cognitive Decline and Neuropathology
Speaker
Networking Lunch
Targeting Vascular Activation: A New Therapeutic Approach to Alzheimer's Disease
Speaker
Tau Immunotherapy: Finding the Right Antibody for the Right Tau Species
Speaker
The Role of Autophagy in Alzheimer’s Disease
Speaker
Networking Coffee Break
The Antimicrobial Protection Hypothesis of Alzheimer’s Disease
Speaker
Panel Discussion: Identifying Therapeutic Strategies to Combat Alzheimer’s Disease
Speaker
Closing Remarks
Speaker