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Alzheimer’s Disease Therapeutics: Alternatives to Amyloid

Alzheimer’s Disease Therapeutics: Alternatives to Amyloid

Tuesday, December 11, 2018, 9:00 AM - 6:00 PM

The New York Academy of Sciences, 7 World Trade Center, 250 Greenwich St Fl 40, New York

Presented By

The New York Academy of Sciences

The Brain and Behavior Discussion Group

 

For years, the Alzheimer’s research community has been focused on amyloid as the key to curing this devastating disease.  However, there are currently only four drugs approved to treat the symptoms of Alzheimer’s disease, and no new therapies have been approved in the last 15 years.  Moreover, multiple clinical trials have recently failed, including several Phase III trials that targeted amyloid with antibodies.  As a result, there is burgeoning interest in identifying alternative drug targets: over half of ongoing preclinical research in Alzheimer’s disease now focuses on pathways other than amyloid and tau.

This one-day symposium will highlight emerging mechanisms driving Alzheimer's disease — including mitochondrial factors, the vascular system, infections, and autophagy — as well as discuss strategies to identify new therapeutic targets.

Call for Abstracts

Abstract submissions are invited for a poster session. For complete submission instructions, please visit our online portal. The deadline for abstract submission is Friday, November 2, 2018.

Registration

Member
$60
Nonmember Academia, Faculty, etc.
$105
Nonmember Corporate, Other
$160
Nonmember Not for Profit
$105
Nonmember Student, Undergrad, Grad, Fellow
$70
Member Student, Post-Doc, Fellow
$25
Deadline:
15
days
left

Scientific Organizing Committee

Howard Fillit, MD,  Alzheimer's Drug Discovery Foundation
Howard Fillit, MD,
Alzheimer's Drug Discovery Foundation
Nell Rebowe,   Anavex Life Sciences
Nell Rebowe,
Anavex Life Sciences
Rudolph Tanzi, PhD,  Harvard Medical School
Rudolph Tanzi, PhD,
Harvard Medical School
George Zavoico, PhD,  B. Riley FBR
George Zavoico, PhD,
B. Riley FBR
Sara Donnelly, PhD,  The New York Academy of Sciences
Sara Donnelly, PhD,
The New York Academy of Sciences
Sonya Dougal, PhD,  The New York Academy of Sciences
Sonya Dougal, PhD,
The New York Academy of Sciences
Amanda Sadacca, PhD,  The New York Academy of Sciences
Amanda Sadacca, PhD,
The New York Academy of Sciences

Speakers

Ana Maria Cuervo, MD, PhD,  Albert Einstein College of Medicine
Ana Maria Cuervo, MD, PhD,
Albert Einstein College of Medicine
Howard Fillit, MD,  Alzheimer's Drug Discovery Foundation
Howard Fillit, MD,
Alzheimer's Drug Discovery Foundation
Paula Grammas
Paula Grammas, PhD,
University of Rhode Island
Jacob Hooker, PhD,  Harvard Medical School
Jacob Hooker, PhD,
Harvard Medical School
Xavier Langlois
Xavier Langlois, PhD,
Abbvie
Christopher Missling, PhD,  Anavex Life Sciences
Christopher Missling, PhD,
Anavex Life Sciences
Robert Moir, PhD,  Harvard Medical School
Robert Moir, PhD,
Harvard Medical School
Rudolph Tanzi, PhD,  Harvard Medical School
Rudolph Tanzi, PhD,
Harvard Medical School
Eugenia Trushina, PhD,  Mayo Clinic
Eugenia Trushina, PhD,
Mayo Clinic

Tuesday

December 11, 2018

8:30 AM

Breakfast and Registration

9:00 AM

Introduction and Welcome Remarks

Speakers

Amanda Sadacca, PhD
The New York Academy of Sciences
George Zavoico, PhD
B. Riley FBR
9:15 AM

Overview of the Current State of Alzheimer’s Disease Therapeutics

Speaker

Howard Fillit, MD
Alzheimer’s Drug Discovery Foundation
9:30 AM

Mechanisms of Alzheimer’s and Other Neurodegenerative Diseases

Speaker

Rudolf Tanzi, PhD
Harvard University
10:00 AM

Novel Tools to Study Epigenetic Changes in Neurodegenerative Diseases

Speaker

Jacob Hooker, PhD
Harvard Medical School
10:30 AM

Networking Coffee Break

11:00 AM

Mitochondrial Dysfunction and Alzheimer’s Disease

Speaker

Eugenia Trushina, PhD
Mayo Clinic
11:30 AM

Precision Medicine Approach for Treating Neurological Diseases via Sigma-1 Receptor Activation

Speaker

Christopher Missling, PhD
Anavex Life Sciences
12:00 PM

3x Data Blitz Talks – Selected from submitted abstracts

12:15 PM

Networking Lunch

1:30 PM

Amyloid Seeding as a Response to Infection

Speaker

Robert Moir, PhD
Harvard Medical School
2:00 PM

The Role of Autophagy in Alzheimer’s Disease

Speaker

Ana Maria Cuervo, MD, PhD
Albert Einstein College of Medicine
2:30 PM

Developing Immunotherapies to Target Tau

Speaker

Xavier Langlois, PhD
AbbVie
3:00 PM

Networking Coffee Break

3:30 PM

Targeting Vascular Activation in Alzheimer’s Disease

Speaker

Paula Grammas, PhD
University of Rhode Island
4:00 PM

Panel Discussion: Identifying Therapeutic Strategies to Combat Alzheimer’s Disease

4:45 PM

Closing Remarks

5:00 PM

Poster Session and Networking Reception

6:00 PM

Adjourn