Genome Integrity Discussion Group April 2018
Monday, April 9, 2018, 1:30 PM - 5:30 PM EDT
The New York Academy of Sciences
115 Broadway, 7th Floor, New York City, 10006 USA
The connection between cancer and genome integrity is widely appreciated. Importantly, the greater New York Metropolitan area is unparalleled in the concentration of world leading research on chromosome biology and function, as well as for research at the interface between chromosome integrity and the dynamics of malignancy. The Genome Integrity Discussion Group capitalize on this concentration of excellence, providing a forum for interaction between basic- and clinically-oriented research groups working in these fields. These meetings not only facilitate synergy between labs, but also provide a context in which previously unappreciated complementarities can be revealed.
In that spirit, the talks will cover a broad range of areas, including, but not limited to the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states, and it is expected that this will be reflected in the substance of our discussions. At each of the meetings, two early career scientists (students or postdocs) are selected to present data.
Genome Integrity Discussion Group meetings are organized under the leadership of Scott Keeney (Memorial Sloan Kettering Cancer Center), Susan Smith (NYU Langone Medical Center), and Lorraine Symington (Columbia University Irving Medical Center).
April 09, 2018
Welcome and Introductory Remarks
Pathways and Pitfalls in Base Excision DNA Repair
ncRNA-programmed Genome Rearrangement in the Ciliate Oxytricha
The Spliceosomal Component Sf3b1 Protects Embryonic Neurons from R-loop Mediated DNA Damage
Non-Canonical Homology-Directed Repair Pathway Resolves Replication Stress During Alternative Lengthening of Telomeres
Mechanisms of Condensin Mediated Gene Regulation in C. Elegans
Mechanistic Studies of Gene Silencing Complexes