Sohn Conference: Accelerating Translation of Pediatric Cancer Research

Sohn Conference: Accelerating Translation of Pediatric Cancer Research

Monday, February 26, 2018 - Wednesday, February 28, 2018

The Royal Society, 6-9 Carlton House Terrace, London, United Kingdom

This event is not organized or endorsed by The Royal Society

Presented By

The Sohn Conference Foundation

The New York Academy of Sciences

 

Pediatric cancer is the leading cause of death by disease past infancy among children in the United States and Europe. Despite prevailing increases in overall survival rates, it continues to be one of the most challenging diseases to treat. Our basic understanding of pediatric cancer biology has improved, but high rates of relapse remain; and 20% of pediatric cancer patients do not respond to therapy, ultimately dying from their disease. We now understand that childhood cancers are genetically distinct from their adult counterparts, and that current treatments developed for adults are particularly harsh on growing children, causing severe side effects. Thus, there is a critical need to refine established therapeutic approaches for this vulnerable population to improve treatment for patients around the world.

This 2.5-day international conference will advance the dialogue from the first meeting presented jointly by the Sohn Conference Foundation and the New York Academy of Sciences in 2016, the Sohn Conference: Pediatric Cancer in a Post-genomic World. Leading researchers, clinicians, pediatric cancer advocates, and industry and governmental stakeholders from around the globe will reconvene, this time in London, England, to discuss strategies to help bridge the gap between basic research discoveries and treatments for pediatric and adolescent cancer patients. The aim will be to provide a platform for these leaders from different countries and continents to share promising new findings, identify best practices, and develop a unified approach. Conference speakers will present emerging basic and clinical cutting edge research in pediatric cancers on topics including somatic and germline alterations, genomics and epigenomics, opportunities and challenges in immunotherapy, developmental biology, biology of tumor progression and relapse, technologies for non-invasive disease monitoring, biological determinants of survival, and strategies challenges in clinical trial design and drug development.

Abstracts and Fellowships

Call for Abstracts

Abstract submissions are invited for a poster session and top abstracts will be selected for short talks. Please see complete submission instructions here; to submit your abstract please visit our online portal. The deadline for abstract submission is December 4, 2017.

Call for Early Career Investigator and Underrepresented Minority Travel Fellowship Applications

Applications are invited from qualified early career investigators and from underrepresented minorities. Please see detailed information on eligibility and application instructions here; to submit your application, please visit our online portal. The deadline for submission is December 4, 2017.

Registration

Member
By 01/15/2018
$205
After 01/15/2018
$240
Onsite
$275
Nonmember Academia, Faculty, etc.
By 01/15/2018
$255
After 01/15/2018
$290
Onsite
$330
Nonmember Corporate, Other
By 01/15/2018
$360
After 01/15/2018
$420
Onsite
$470
Nonmember Not for Profit
By 01/15/2018
$255
After 01/15/2018
$290
Onsite
$330
Nonmember Student, Undergrad, Grad, Fellow
By 01/15/2018
$140
After 01/15/2018
$170
Onsite
$200
Member Student, Post-Doc, Fellow
By 01/15/2018
$105
After 01/15/2018
$135
Onsite
$185

Organizers

Sohn Conference: Accelerating Translation of Pediatric Cancer Research
John Anderson, PhD, University College London Great Ormond Street Institute of Child Health, United Kingdom
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Louis Chesler, PhD, MD, FRCPCH, The Royal Marsden; The Institute of Cancer Research, United Kingdom
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Richard Gilbertson, MD, PhD, Cancer Research UK Cambridge Institute; University of Cambridge, United Kingdom
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Lee J. Helman, MD, Children’s Hospital Los Angeles and the Norris Comprehensive Cancer Center, University of Southern California
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Andrew Kung, MD, PhD, Memorial Sloan Kettering Cancer Center
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
John M. Maris, MD, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Kathy Pritchard-Jones, BM BCh, PhD, FRCPCH, University College London Great Ormond Street Institute of Child Health, United Kingdom
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Poul Sorensen, MD, PhD, FRCPC¸ British Columbia Cancer Research Centre; The University of British Columbia, Canada
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Kimberly Stegmaier, MD, Dana-Farber Cancer Institute; Harvard Medical School; Boston Children's Hospital
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Gilles Vassal, MD, PhD, Institut Gustave Roussy, France
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Lauren Breslow, JD, MPH, The Sohn Conference Foundation
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Melanie Brickman Borchard, PhD, MSc, The New York Academy of Sciences
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Alison Carley, PhD, The New York Academy of Sciences
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Jennifer Lazar Schiamberg, The Sohn Conference Foundation

Keynote Speakers

Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Richard Gilbertson, MD, PhD, Cancer Research UK Cambridge Institute; University of Cambridge, United Kingdom
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Mignon Lee-Cheun Loh, MD, University of California, San Francisco

Speakers

Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Scott Armstrong, MD, PhD, Dana-Farber Cancer Institute, Boston Children’s Hospital, Harvard Medical School, Broad Institute of MIT and Harvard
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Smita Bhatia, MD, MPH, The University of Alabama at Birmingham
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Kevin M. Brindle, PhD, FMedSci, Cancer Research UK Cambridge Institute, University of Cambridge, United Kingdom
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Brice Fresneau, MD, PhD, Institut Gustave Roussy, France
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
David Malkin, MD, FRCP(C), FAAP, The Hospital for Sick Children, Canada
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Yael P. Mossé, MD, Children’s Hospital of Philadelphia
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Stefan Pfister, MD, Heidelberg University Hospital and German Cancer Research Center, Germany
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Nazneen Rahman, MD, PhD, The Institute of Cancer Research, United Kingdom
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Raphaël Rousseau, MD, PhD, Gritstone Oncology, Inc.
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Gudrun Schleiermacher, MD, PhD, Institut Curie, France
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Uri Tabori, MD, The Hospital for Sick Children, Canada
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Michael Taylor, MD, PhD, FRCS(C), The Hospital for Sick Children, Canada
Sohn Conference: Accelerating Translation of Pediatric Cancer Research
Matthew Vander Heiden, MD, PhD, Koch Institute for Integrative Cancer Research at MIT

Presented by

The Sohn Conference Foundation supports innovative initiatives that promote its mission to treat and cure pediatric cancer.  Toward this goal, the Foundation seeks to embolden elite scientists researching pediatric cancers to collaborate across institutions and, with this Conference, across nations, to further research toward cures.  This Conference is also a meaningful reflection of the Foundation’s unique philanthropic model: the Foundation raises funds by convening leading investment professionals to share their best ideas and fundraise for the cause of pediatric cancer research.  It is therefore the Foundation’s privilege to partner with the New York Academy of Sciences to convene the world’s scientific leaders who will change the course of treating pediatric cancer, ultimately, saving more children from cancer and treatment side-effects.

Monday

February 26, 2018

1:10 PM

Registration

1:30 PM

Introduction and Welcome Remarks

Speakers

Piers Butler
The Sohn Foundation London
Melanie Brickman Borchard, PhD, MSc
The New York Academy of Sciences
1:40 PM

Day 1 Keynote Address: Planes, Trains and Different-fields

Speaker

Richard Gilbertson, MD, PhD
Cancer Research UK Cambridge Institute and University of Cambridge, United Kingdom

Session I: Inherited Predisposition to Childhood Cancers

Session Chairperson
John Maris, MD, The Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, United States
2:20 PM

Li-Fraumeni Syndrome: The Molecular Basis of Cancer Predisposition, Early Detection and Prevention

Speaker

David Malkin, MD
The Hospital for Sick Children, Canada
2:45 PM

Genetic Predisposition to Childhood Cancer — Opportunities and Challenges

Speaker

Nazneen Rahman, MD, PhD
The Institute of Cancer Research, United Kingdom
3:10 PM

Networking Coffee Break

Session II: Somatic Alterations in Pediatric Cancers: Genomics and Epigenomics

Session Chairperson
Lee Helman, MD, Children’s Hospital of Los Angeles, United States
3:40 PM

New Vulnerabilities in Pediatric Cancer

Speaker

Kimberly Stegmaier, MD
Dana-Farber Cancer Institute, Harvard Medical School, and Boston Children's Hospital, United States
4:05 PM

TBD

Speaker

Speaker to Be Announced
4:30 PM

Next-generation Diagnostics in Pediatric Neurooncology

Speaker

Stefan Pfister, MD
German Cancer Research Center (DKFZ), Germany
4:55 PM

Closing Remarks

5:05 PM

Day 1 Ends

Tuesday

February 27, 2018

9:00 AM

Networking Breakfast, Poster Set Up

Session III: Opportunities and Challenges in Immunotherapy for the Treatment of Pediatric Cancers

Session Chairperson
Kimberly Stegmaier, MD, Dana-Farber Cancer Institute, Harvard Medical School, and Boston Children's Hospital, United States
9:30 AM

Targeting Childhood Solid Cancers with Engineered T Cells

Speaker

John Anderson, PhD
University College London Great Ormond Street Institute of Child Health, United Kingdom
9:55 AM

Pediatric Cancer Immunotherapy: Not a Trickle Down from Medical Oncology

Speaker

John Maris, MD
The Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, United States
10:20 AM

The Role of Hypermutation and Replication Repair Deficiency in Response of Childhood Cancers to Immune Checkpoint Inhibitors

Speaker

Uri Tabori, MD
The Hospital for Sick Children, Canada
10:45 AM

Networking Coffee Break

Session IV: Incorporating Developmental Biology into Our Understanding of Pediatric Cancers

Session Chairperson
Richard Gilbertson, MD, PhD, Cancer Research UK Cambridge Institute and University of Cambridge, United Kingdom
11:15 AM

Title to Be Announced

Speaker

Louis Chesler, PHD, MD, FRCPCH
The Royal Marsden and The Institute of Cancer Research, United Kingdom
11:40 AM

Title to Be Announced

Speaker

Scott Armstrong, MD, PhD
Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, and Broad Institute of MIT and Harvard, United States
12:05 PM

Networking Lunch and Poster Viewing

Session V: Hot Topic Talks from Submitted Abstracts

Session Chairperson
Poul Sorensen, MD, PhD, British Columbia Cancer Research Centre and University of British Columbia, Canada
1:20 PM

Selected from Submitted Abstracts

1:35 PM

Selected from Submitted Abstracts

Session VI: Emerging Biology of Tumor Progression and Relapse

Session Chairperson
Gilles Vassal, MD, PhD, Institut Gustave Roussy, France
1:50 PM

Stress-mediated Translational Control of Sarcoma Metastasis

Speaker

Poul Sorensen, MD, PhD
British Columbia Cancer Research Centre and University of British Columbia, Canada
2:15 PM

Title to Be Announced

Speaker

Matthew Vander Heiden, MD, PhD
Koch Institute for Integrative Cancer Research at MIT, United States
2:40 PM

Heterogeneity through Space and Time Drive the Clinical Behavior of Childhood Brain Cancers

Speaker

Michael D. Taylor, MD, PhD, FRCS(C)
The Hospital for Sick Children, Canada
3:05 PM

Title to Be Announced

Speaker

Andrew Kung, MD, PhD
Memorial Sloan Kettering Cancer Center, United States
3:30 PM

Day 2 Closing Remarks

3:35 PM

Networking Reception and Poster Session

5:00 PM

Day 2 Ends

Wednesday

February 28, 2018

9:00 AM

Networking Breakfast

9:30 AM

Day 3 Keynote Address:

Speaker

Mignon Lee-Cheun Loh, MD
University of California, San Francisco, United States
10:10 AM

Networking Coffee Break

Session VII: Strategies and Challenges in Clinical Trial Design and Drug Development

Session Chairperson
John Anderson, PhD, University College London Institute of Child Health, United Kingdom
10:40 AM

Innovative Designs and Strategy to Accelerate Translation of Pediatric Cancer Research into New Effective Therapies

Speaker

Gilles Vassal, MD, PhD
Institut Gustave Roussy, France
11:05 AM

Title to Be Announced

Speaker

Yael P. Mossé, MD
Children's Hospital of Philadelphia, United States
11:30 AM

Accelerating New Drug Development for Children with Cancer: An Industry Perspective

Speaker

Raphaël Rousseau, MD, PhD
Gritstone Oncology, Inc., United States
11:55 AM

Panel Discussion: Accelerating Drug Development

12:45 PM - 1:55 PM

Networking Lunch

Early Career Investigator and Underrepresented Minority Mentoring Lunch

For Graduate Students, Post-doctoral Fellows, and Junior Faculty

Session VIII: Emerging Technologies in Non-invasive Disease Monitoring

Session Chairperson
Louis Chesler, PHD, MD, FRCPCH, The Royal Marsden and The Institute of Cancer Research, United Kingdom
1:55 PM

Development of Liquid Biopsies/cfDNA in Osteosarcoma: An Unmet Need

Speaker

Lee Helman, MD
Children’s Hospital of Los Angeles, University of Southern California, United States
2:20 PM

Title to Be Announced

Speaker

Gudrun Schleiermacher, MD, PhD
Institut Curie, Paris, France
2:45 PM

Imaging Tumor Cell Metabolism with Hyperpolarized Carbon 13-labelled Cell Substrates — from Mouse to Man

Speaker

Kevin Brindle, BA, MA, D.Phil.
University of Cambridge, United Kingdom
3:10 PM

Networking Coffee Break

Session IX: Hot Topic Talks from Submitted Abstracts

Session Chairperson
Andrew Kung, MD, PhD, Memorial Sloan Kettering Cancer Center, United States
3:35 PM

Selected from Submitted Abstracts

3:50 PM

Selected from Submitted Abstracts

Session X: Biological Determinants and Risk Factors of Survivorship in Pediatric Cancers

Session Chairperson
Kathy Pritchard Jones, BM BCh, PhD, FRCPCH, Great Ormond Street Institute of Child Health, University College London, United Kingdom
4:05 PM

Mitigating the Risk of Treatment-related Complications in Childhood Cancer Survivors — Are We There Yet?

Speaker

Smita Bhatia, MD, MPH
The University of Alabama at Birmingham, United States
4:30 PM

Title to Be Announced

Speaker

Brice Fresneau, MD, PhD
Institut Gustave Roussy, France
4:55 PM

Day 3 Closing Remarks

5:00 PM

Conference Adjourns