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Alzheimer's Disease Therapeutics: Alternatives to Amyloid 2019

Available via

WEBINAR

Alzheimer's Disease Therapeutics: Alternatives to Amyloid 2019

Wednesday, November 20, 2019, 8:30 AM - 5:30 PM

The New York Academy of Sciences, 7 World Trade Center, 250 Greenwich St Fl 40, New York

Presented By

Brain and Behavior Discussion Group

The New York Academy of Sciences

 

For the last 25 years, research in Alzheimer’s disease has focused on amyloid as the key driver of disease pathogenesis. However, the recent failure of several Phase III clinical trials targeting amyloid has reinforced the need to critically evaluate these trials and consider different approaches.  There is burgeoning interest in identifying alternative drug targets: over half of ongoing preclinical research in Alzheimer’s disease now focuses on neuro-inflammation, bioenergetics, epigenetics, protein homeostasis and other alternative pathways.

This conference will consider the landscape of Alzheimer’s disease research including the current state of the amyloid hypothesis, emerging disease mechanisms, and strategies to develop novel therapeutic approaches.

Call for Abstracts

Abstract submissions are invited for a poster session. For complete submission instructions, please visit our online portal. The deadline for abstract submission is Friday, September 20, 2019.

Registration

Member
By 10/11/2019
$90
After 10/11/2019
$130
Nonmember Academia, Faculty, etc.
By 10/11/2019
$180
After 10/11/2019
$260
Nonmember Corporate, Other
By 10/11/2019
$250
After 10/11/2019
$350
Nonmember Not for Profit
By 10/11/2019
$180
After 10/11/2019
$260
Nonmember Student, Undergrad, Grad, Fellow
By 10/11/2019
$100
After 10/11/2019
$145
Member Student, Post-Doc, Fellow
By 10/11/2019
$50
After 10/11/2019
$70
Member
$30
Nonmember Academia, Faculty, etc.
$65
Nonmember Corporate, Other
$85
Nonmember Not for Profit
$65
Nonmember Student, Undergrad, Grad, Fellow
$45
Member Student, Post-Doc, Fellow
$15
Deadline:
3
days
left

Scientific Organizing Committee

Howard Fillit, MD
Howard Fillit, MD

Alzheimer's Drug Discovery Foundation

Rudolph Tanzi, PhD
Rudolph Tanzi, PhD

Harvard Medical School

George Zavoico, PhD
George Zavoico, PhD

B. Riley FBR

Sara Donnelly, PhD
Sara Donnelly, PhD

The New York Academy of Sciences

Sonya Dougal, PhD
Sonya Dougal, PhD

The New York Academy of Sciences

Speakers

David Holtzman, MD
David Holtzman, MD

Washington University School of Medicine

Roberta Brinton, PhD
Roberta Brinton, PhD

University of Arizona

Marco Colonna, MD
Marco Colonna, MD

Washington Unversity School of Medicine

Cheryl Wellington, PhD
Cheryl Wellington, PhD

University of British Columbia

Joel Dudley, PhD
Joel Dudley, PhD

Icahn School of Medicine at Mount Sinai

Sangram Sisodia, PhD
Sangram Sisodia, PhD

University of Chicago

Manolis Kellis
Manolis Kellis, PhD

Massachusetts Institute of Technology

Lisa Mosconi, PhD
Lisa Mosconi, PhD

Weill Cornell Medical College

Bradley Hyman, MD, PhD
Bradley Hyman, MD, PhD

Massachusetts General Hospital, Harvard Medical School

Marilyn Albert, PhD
Marilyn Albert, PhD

Johns Hopkins University

Malú Tansey, PhD
Malú Tansey, PhD

University of Florida College of Medicine

Wednesday

November 20, 2019

8:30 AM

Breakfast and Registration

9:00 AM

Introduction and Welcome Remarks

Session 1: Perspectives on the Future of Alzheimer’s Disease Research

9:15 AM

What Would be Good Targets to Prevent or Treat Alzheimer's Disease?

Speaker

David Holtzman, MD
Washington University School of Medicine
9:45 AM

Panel Discussion: Therapeutic Strategies and New Targets

Speakers

Moderator: Rudolph Tanzi, PhD
Harvard Medical School
Roberta Brinton, PhD
University of Arizona
Brad Hyman, MD, PhD
Massachusetts General Hospital
Marilyn Albert, PhD
Johns Hopkins University
David Holtzman, MD
Washington University School of Medicine
10:30 AM

Networking Coffee Break

Session 2: Neuroinflammation and Tau as Drivers of Disease

11:00 AM

TNF-dependent Neuroinflammation in Alzheimer’s Disease

Speaker

Malú Tansey, PhD
University of Florida
11:30 AM

Innate Immunity in Neurodegeneration

Speaker

Marco Colonna, PhD
Washington University School of Medicine
12:00 PM

Age Dependent Spread of Tau in Alzheimer’s Disease

Speaker

Brad Hyman, MD, PhD
Massachusetts General Hospital
12:30 PM

Networking Lunch and Poster Session

Speakers

Odd Number Poster Boards
12:30 PM - 1:00 PM
Even Number Poster Boards
1:00 PM - 1:30 PM

Session 3: Risk Factors, Biomarkers and Early Detection

1:30 PM

Regenerating the Degenerated Alzheimer’s Brain: Challenges and Innovation Opportunities

Speaker

Roberta Brinton, PhD
University of Arizona
2:00 PM

Sex-Specific Modulation of Amyloid Deposition and Neuroinflammation by the Microbiome

Speaker

Sangram Sisodia, PhD
University of Chicago
2:30 PM

Neuro-imaging Identifies Risk Factors for Alzheimer’s Disease

Speaker

Lisa Mosconi, PhD
Weill Cornell Medical College
3:00 PM

Alzheimer’s Disease Biomarkers

Speaker

Marilyn Albert, PhD
Johns Hopkins University
3:30 PM

Networking Coffee Break

Session 4: Emerging Mechanistic Insights for Alzheimer’s Disease

4:00 PM

New Insights into the Role of Lipoproteins in Alzheimer’s Disease

Speaker

Cheryl Wellington, PhD
University of British Columbia
4:30 PM

Single-Cell Dissection of Alzheimer’s Disease

Speaker

Manolis Kelis
Massachusetts Institute of Technology
5:00 PM

Role of Human Herpesvirus in Alzheimer’s Disease

Speaker

Joel Dudley, PhD
Icahn School of Medicine at Mount Sinai
5:30 PM

Closing Remarks

5:45 PM

Networking Reception and Poster Session

6:45 PM

Adjourn