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dividing cells; regenerative medicine


for Members

Frontiers in Regenerative Medicine: 2019 Innovators in Science Award Symposium

Friday, April 26, 2019

9:30AM to 6:00PM JST
Shonan iPark, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, JPN

Presented By

The New York Academy of Sciences

Takeda Pharmaceutical Company Limited


The Innovators in Science Award was established in 2016 as a partnership between the New York Academy of Sciences and Takeda Pharmaceuticals to recognize creative and impactful research being conducted around the world. This symposium will showcase the achievements of the 2019 Innovators in Science Award Winners in Regenerative Medicine and feature presentations from world leaders in stem cell research and clinical applications. During this event, Dr. Shinya Yamanaka, Nobel Laureate and Director of the Center for iPS Cell Research and Application at Kyoto University, will be the keynote speaker among a group of luminaries who will discuss advances in regenerative medicine and the growing impact of the field on human health.

Please join us at Shonan iPark in Kanagawa, Japan for a unique opportunity to engage with leading researchers, clinicians, and prominent industry stakeholders from around the world about the transformational research happening at the forefront of regenerative medicine today.

This event is free, but registration is required. Although on-site registration may be possible on the day of the event, pre-registration is highly encouraged due to space limitations. Registration will open in August 2018.

Award Program

The Innovators in Science Award recognizes a promising Early-Career Scientist and an outstanding Senior Scientist for their contributions to science in the therapeutic areas of Neuroscience, Gastroenterology, Regenerative Medicine, and Oncology. Each Award Winner receives a prize of US $200,000 intended to support their commitment to innovative research.

In 2019, academic, government, and non-profit institutions from around the globe, as well as the Award’s own distinguished Scientific Advisory Council, nominated candidates who are conducting groundbreaking research in the field of regenerative medicine. The 2019 Award Jury of international experts in regenerative medicine will convene in Fall 2018 at the New York Academy of Sciences in New York City to choose the Award Winners. Winners will be announced in January 2019 and Awards will be conferred at a formal ceremony on April 25, 2019, in Tokyo, Japan.



Andrew Plump, MD, PhD,
Takeda Pharmaceutical Company Limited
Brooke Grindlinger, PhD,
The New York Academy of Sciences
Adria Martig, PhD,
The New York Academy of Sciences


April 26, 2019

9:30 AM

Registration & Breakfast

10:00 AM

Welcome Remarks & Introduction

Keynote Lecture

10:15 AM

Keynote Lecture


Shinya Yamanaka
Kyoto University
11:00 AM

Networking Coffee Break

Early-Career Scientist Award Winner Lecture

11:15 AM

2019 Early-Career Scientist Winner Lecture


Shruti Naik
New York University

Senior Scientist Award Winner Lecture

12:00 PM

2019 Senior Scientist Winner Lecture


Michele De Luca
University of Modena and Reggio Emilia
12:45 PM

Networking Luncheon

Clinical Applications in Regenerative Medicine

2:00 PM

Distinguished Lecture


Masayo Takahashi
RIKEN Center for Biosystems Dynamics Research
2:45 PM

Long-term Ex Vivo Expansion of Functional Hematopoietic Stem Cells: A Step Towards a Holy Grail in Hematology


Hiromitsu Nakauchi
University of Tokyo & Stanford University

Multipotent self-renewing hematopoietic stem cells (HSCs) maintain hematopoiesis throughout life. The mechanism of such striking capability of HSCs remains unanswered, mainly because of the paucity of HSCs in the bone marrow. Ex vivo expansion has been a holy grail of HSC research, yet, no such system exists despite numerous studies over the decades. Here we developed a simple platform to expand functional mouse HSCs ~900-fold over 28-days using a chemically-defined, albumin-free culture conditions. The large numbers of ex vivo expanded HSCs enabled non-myeloablative HSC transplantation, curative for immunodeficient recipients. Thus, the ex vivo expansion of HSCs provides a platform not only to interrogate HSC self-renewal and lineage commitment but also suggests a novel approach in clinical HSC transplantation.

3:30 PM

Networking Coffee Break

Advances in Regenerative Medicine Research

3:45 PM

The Embryonic Stem Cell Transition


Austin Smith
University of Cambridge

Pluripotent cells emerge as a naïve founder population in the mammalian blastocyst. They then develop capacity for germline and somatic specification prior to lineage priming and differentiation. Mouse embryonic stem cells and post-implantation epiblast stem cells (EpiSC) represent the early naïve and late primed stages of pluripotency respectively. Between these two stages a formative transition occurs, in vitro and in the embryo, through which competence is acquired for multi-lineage induction. This transition is driven by three complementary transcription factor activities which orchestrate dismantling of the naïve pluripotency gene regulatory network and commissioning of the formative state.

4:30 PM

Moderated Panel Discussion


Azim Surani (moderator)
University of Cambridge
Brigid L.M. Hogan
Duke University School of Medicine
Emmanuelle Passegué
Columbia University Irving Medical Center
Hans Schöler
Max Planck Institute for Molecular Biomedicine
5:15 PM

Closing Remarks

5:20 PM

Networking Reception

6:20 PM

Event Adjourns