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Protein Folding in Health and Disease: The 2019 Dr. Paul Janssen Award Symposium

FREE

for Members

Protein Folding in Health and Disease: The 2019 Dr. Paul Janssen Award Symposium

Friday, October 4, 2019, 9:00 AM - 2:30 PM

The New York Academy of Sciences, 7 World Trade Center, 250 Greenwich St Fl 40, New York

Presented By

 

Proteins are responsible for a wide range of functions in cells, including structure, catalysis, transport, and signaling. In order to carry out their myriad roles, these strings of amino acids must fold into proper conformation. Franz-Ulrich Hartl, MD, of the Max Planck Institute of Biochemistry and Arthur Horwich, MD, of Yale School of Medicine and Howard Hughes Medical Institute, have dedicated their careers to better understanding the molecular machinery that drives protein folding, and the implications when a protein misfolds. Prior to their groundbreaking work, it was thought that proteins folded spontaneously within cells, with the structure determined by the amino acid sequence. While studying mitochondrial protein import, which importantly requires that proteins be unfolded and refolded, Drs. Horwich and Hartl hypothesized that the process may not be spontaneous but dependent on cellular machinery. Indeed, they discovered a new class of proteins that facilitate protein folding. These protein folders, part of the chaperone family of proteins, improve the efficiency of protein folding in cells and help avoid the formation of unfolded protein aggregates. Proper protein folding is important to human biology and health, as defects in folding are associated with aging and diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and prion disease.

For their revolutionary insights into chaperone-mediated protein folding, Drs. Hartl and Horwich will receive the 2019 Dr. Paul Janssen Award for Biomedical Research. This half-day symposium, Protein Folding in Health and Disease: The 2019 Dr. Paul Janssen Award Symposium, will celebrate their work. Following award lectures from Drs. Hartl and Horwich, fellow prominent scientists will discuss several aspects of protein folding, from basic biology to the implications for human disease.

Symposium registration is free. Although on-site registration may be possible on the day of the event, pre-registration is highly encouraged due to space limitations.

Registration

Individual
$0

Honorees and Speakers

Franz Ulrich Hartl
Franz-Ulrich Hartl, MD

Max Planck Institute of Biochemistry

Arthur Horwich
Arthur Horwich, MD

Yale School of Medicine and Howard Hughes Medical Institute

Speakers

David S. Bredt, MD, PhD
David S. Bredt, MD, PhD

Janssen Pharmaceutical Companies of Johnson & Johnson

Andrew Dillin, PhD
Andrew Dillin, PhD

University of California, Berkeley and Howard Hughes Medical Institute

Judith Frydman
Judith Frydman, PhD

Stanford University

Lila M. Gierasch, PhD
Lila M. Gierasch, PhD

University of Massachusetts, Amherst

This symposium is made possible with support from:


Friday

October 04, 2019

8:00 AM

Registration and Breakfast

9:00 AM

Welcome and Introductory Remarks

Speakers

Ellis Rubinstein
The New York Academy of Sciences
Seema Kumar
Johnson & Johnson
9:10 AM

2019 Dr. Paul Janssen Award for Biomedical Research Announcement

Speaker

Seema Kumar
Johnson & Johnson
9:20 AM

Molecular Chaperones — Central Players of the Proteostasis Network

Speaker

Franz-Ulrich Hartl, MD
Max Planck Institute of Biochemistry
9:55 AM

Chaperonin-mediated Protein Folding

Speaker

Arthur Horwich, MD
Yale School of Medicine and Howard Hughes Medical Institute
10:30 AM

Maintaining Proteostasis: The Pathways and Principles of Eukaryotic Protein Quality Control

Speaker

Judith Frydman, PhD
Stanford University
10:55 AM

Neuroendocrine Regulation of ER Stress and Aging

Speaker

Andrew Dillin, PhD
University of California, Berkeley and Howard Hughes Medical Institute
11:20 AM

Coffee and Networking Break

11:50 AM

The Versatile Hsp70 Molecular Chaperone Machine

Speaker

Lila M. Gierasch, PhD
University of Massachusetts, Amherst
12:15 PM

Getting a Handle on Neuropharmacology by Targeting Receptor Chaperones

Speaker

David S. Bredt, MD, PhD
Janssen Pharmaceutical Companies of Johnson & Johnson
12:45 PM

Panel Discussion

Speakers

Moderator: Seema Kumar
Johnson & Johnson
Panelist: Franz-Ulrich Hartl, MD
Max Planck Institute of Biochemistry
Panelist: Arthur Horwich, MD
Yale School of Medicine and Howard Hughes Medical Institute
1:15 PM

Luncheon

2:30 PM

Adjourn

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