Protein Folding in Health and Disease: The 2019 Dr. Paul Janssen Award Symposium
Friday, October 4, 2019, 9:00 AM - 2:30 PM
The New York Academy of Sciences, 7 World Trade Center, 250 Greenwich St Fl 40, New York
The New York Academy of Sciences
Proteins are responsible for a wide range of functions in cells, including structure, catalysis, transport, and signaling. In order to carry out their myriad roles, these strings of amino acids must fold into proper conformation. Franz-Ulrich Hartl, MD, of the Max Planck Institute of Biochemistry and Arthur Horwich, MD, of Yale School of Medicine and Howard Hughes Medical Institute, have dedicated their careers to better understanding the molecular machinery that drives protein folding, and the implications when a protein misfolds. Prior to their groundbreaking work, it was thought that proteins folded spontaneously within cells, with the structure determined by the amino acid sequence. While studying mitochondrial protein import, which importantly requires that proteins be unfolded and refolded, Drs. Horwich and Hartl hypothesized that the process may not be spontaneous but dependent on cellular machinery. Indeed, they discovered a new class of proteins that facilitate protein folding. These protein folders, part of the chaperone family of proteins, improve the efficiency of protein folding in cells and help avoid the formation of unfolded protein aggregates. Proper protein folding is important to human biology and health, as defects in folding are associated with aging and diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and prion disease.
For their revolutionary insights into chaperone-mediated protein folding, Drs. Hartl and Horwich will receive the 2019 Dr. Paul Janssen Award for Biomedical Research. This half-day symposium, Protein Folding in Health and Disease: The 2019 Dr. Paul Janssen Award Symposium, will celebrate their work. Following award lectures from Drs. Hartl and Horwich, fellow prominent scientists will discuss several aspects of protein folding, from basic biology to the implications for human disease.
Symposium registration is free. Although on-site registration may be possible on the day of the event, pre-registration is highly encouraged due to space limitations.
Honorees and Speakers
Max Planck Institute of Biochemistry
Yale School of Medicine and Howard Hughes Medical Institute
Janssen Pharmaceutical Companies of Johnson & Johnson
University of California, Berkeley and Howard Hughes Medical Institute
University of Massachusetts, Amherst
October 04, 2019
Registration and Breakfast
Welcome and Introductory Remarks
2019 Dr. Paul Janssen Award for Biomedical Research Announcement
Molecular Chaperones — Central Players of the Proteostasis Network
Chaperonin-mediated Protein Folding
Maintaining Proteostasis: The Pathways and Principles of Eukaryotic Protein Quality Control
Neuroendocrine Regulation of ER Stress and Aging
Coffee and Networking Break
The Versatile Hsp70 Molecular Chaperone Machine
Getting a Handle on Neuropharmacology by Targeting Receptor Chaperones