
WEBINAR
Only
Novel Inflammatory Pathways in Chronic Human Liver Diseases
Tuesday, October 20, 2020, 10:30 AM - 5:00 PM EDT
The New York Academy of Sciences
115 Broadway, 8th Floor
New York, NY 10006, New York City, 10006 USA
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the world population. Many of these patients subsequently develop non-alcoholic steatohepatitis (NASH), a progressive chronic liver disease for which there is no approved treatment. NASH is projected to be the leading cause of liver failure and transplant in the coming decades. Inflammatory and pro-fibrotic pathways are well established drivers of NASH progression; however, recent work has identified additional cell types as novel regulators of these pathways. Thus, this symposium will focus on less studied immune lineages — such as T helper cells, innate lymphoid cells (ILCs), and natural killer (NK) cells, as well as other non-traditional cell types — including fibroblasts, liver sinusoidal endothelial cells (LSECs), and hepatocytes, which are emerging as critical contributors to NAFLD and NASH. The overarching aim of the meeting is to highlight novel mechanisms that may present new therapeutic targets for chronic liver diseases.
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Tuesday
October 20, 2020
Introduction and Welcome Remarks
Speaker
Keynote: LSEC regulation of Local Immune Responses in the Liver
Speaker
Session 1
Reprogramming Immune Cell Phenotype as an Antifibrogenic Strategy in the Liver: Focus on Macrophages and MAIT Cells
Speaker
Break
Th17 Type Cytokines in Liver Fibrosis
Speaker
iNKT cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury
Speaker
Multi-omics Data Reveal that Low but Differential Expression of IFN-γ Distinctively Breaks Down the Self-Tolerance via Host Gut Microbiota and Metabolic Interactions in Murine Autoimmune Cholangitis
Speaker
Break
Session 2
Liver Sinusoidal Endothelial Cells in Chronic Liver Disease
Speaker
Balancing Hepatic Nutrient Metabolism and Responses to Inflammation
Speaker
Break
Subsets of Innate-like T cells in the Liver and Elsewhere
Speaker
Keynote: How the Gut Microbiome Regulates Anti-Tumor Immunity in the Liver
Speaker