Covalent Modification: Chemical Biology and Therapeutic Applications
Tuesday, November 9, 2021, 10:00 AM - 5:00 PM EST
The New York Academy of Sciences
Covalent target modulation is reemerging as a promising strategy to identify novel therapeutic mechanisms and to drug “tough” targets. Technological advance in proteomics have opened the door to a wider range of targetable residues and set the stage for rational design of covalent modifiers. For example, the development of the KRAS G12C covalent inhibitor has heralded a new paradigm for these agents. This symposium will convene a diverse group of academic and industry scientists from the fields of medicinal chemistry, chemical biology, proteomics and pharmacology to discuss the latest research in the design of covalent libraries and new warheads, addressing intrinsic reactivity of ligands and their relationship to promiscuousness, deconvolution of hits emerging from phenotypic screens, warhead PK tolerance and identification of novel targets in human disease context to name a few. This symposium will empower attendees to think boldly about covalent inhibitors for intractable targets and build confidence in initiating successful covalent screening campaigns, further the ground-breaking work of the speakers and gain confidence in clinical translation of covalent molecules.
University of California, San Francisco
University of California, Los Angeles
Scientific Organizing Committee
University of Virginia