Click here to learn about Academy events, publications and initiatives around COVID-19.

We are experiencing intermittent technical difficulties. At this time, you may not be able to log in, register for an event, or make a donation via the website. We appreciate your patience, and apologize for any inconvenience this may cause.

Our site is under planned maintenance. At this time, you will not be able to log in, register for an event, or make a donation via the website. We appreciate your patience, and apologize for any inconvenience this may cause.

Support The World's Smartest Network
×

Help the New York Academy of Sciences bring late-breaking scientific information about the COVID-19 pandemic to global audiences. Please make a tax-deductible gift today.

DONATE
This site uses cookies.
Learn more.

×

This website uses cookies. Some of the cookies we use are essential for parts of the website to operate while others offer you a better browsing experience. You give us your permission to use cookies, by continuing to use our website after you have received the cookie notification. To find out more about cookies on this website and how to change your cookie settings, see our Privacy policy and Terms of Use.

We encourage you to learn more about cookies on our site in our Privacy policy and Terms of Use.

Genome Integrity Discussion Group December 2021

WEBINAR

Only

Genome Integrity Discussion Group December 2021

Monday, December 6, 2021, 1:30 PM - 5:00 PM EST

Webinar

Presented By

Genome Integrity Discussion Group

The New York Academy of Sciences

 

The greater New York metropolitan area is unparalleled in the concentration of world leading research on chromosome biology and function, as well as for research at the interface between chromosome integrity and the dynamics of malignancy. The Genome Integrity Discussion Group capitalizes on this concentration of excellence, providing a forum for interaction between basic- and clinically-oriented research groups working in these fields. These meetings facilitate synergy between labs, and provide a context in which previously unappreciated complementarities can be revealed.

In that spirit, the talks cover a broad range of areas including the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states.

Registration

Member
$5
Nonmember Academia, Faculty, etc.
$30
Nonmember Corporate, Other
$45
Nonmember Not for Profit
$30
Nonmember Student, Undergrad, Grad, Fellow
$10
Member Student, Post-Doc, Fellow
$0

Speakers

Britt Adamson, PhD
Britt Adamson, PhD

Princeton University

Carolina Reyes Batstia, PhD
Carolina Reyes Batstia, PhD

Columbia University

Jean Gautier, PhD
Jean Gautier, PhD

Columbia University Irving Medical Center

Tuan Nguyen
Tuan Nguyen

Rockefeller University

David Schatz, PhD
David Schatz, PhD

Yale University

Richard Pomerantz, PhD
Richard Pomerantz, PhD

Thomas Jefferson University

Scientific Organizing Committee

Scott Keeney, PhD
Scott Keeney, PhD

Memorial Sloan Kettering Cancer Center

Jean Gautier, PhD
Jean Gautier, PhD

Columbia University Irving Medical Center

Susan Smith, PhD
Susan Smith, PhD

New York University Langone Medical Center

Agata Smogorzewska, MD, PhD
Agata Smogorzewska, MD, PhD

The Rockefeller University

Alison Carley, PhD
Alison Carley, PhD

New York Academy of Sciences

Program Supporters

Monday

December 06, 2021

1:30 PM

Welcome Remarks

1:40 PM

Mapping the Processes of DNA Repair That Impact Genome Editing

Speaker

Britt Adamson, PhD
Princeton University
2:10 PM

Targeting and DNA Repair During Immunoglobulin Somatic Hypermutation

Speaker

David Schatz, PhD
Yale University
2:40 PM

RNA Exosome Drives Early B cell Development via Noncoding RNA Processing Mechanisms

Speaker

Carolina Reyes Batista, PhD
Columbia University
2:55 PM

Break

3:10 PM

Eukaryotic Chromatin Attenuates the Forces Exerted by Sox2 Pioneer Transcription Factor on DNA Through Co-condensation

Speaker

Tuan Nguyen
The Rockefeller University

Formation of biomolecular condensates constitutes an emergingly important mechanism of transcriptional regulation. Recent studies suggest that protein-DNA co-condensation can generate forces driving genomic arrangement. Nonetheless, the extent of mechano-regulation mediated by biomolecular condensates is not well understood, notably within the context of the chromatin. Using single-molecule techniques, we show that Sox2, a model pioneer factor implicated in the regulation of pluripotency, forms biomolecular condensates that exert forces in the order of ~5-7 pN with distinct mechanical effects on DNA in cis and in trans. Moreover, we show that chromatin components, such as nucleosomes and linker histone H1, colocalize with Sox2 and attenuate its force-induced mechanical effects on DNA. Together, our data suggest a mechanism wherein chromatin components can function as a sink to buffer the mechanical stress exerted by biomolecular condensates.

3:25 PM

New Mechanisms for DNA End-joining Polymerases

Speaker

Richard Pomerantz, PhD
Thomas Jefferson University
3:55 PM

Mechanisms of Transcription-coupled Genome Insertions

Speaker

Jean Gautier, PhD
Columbia University Irving Medical Center
4:25 PM

Q&A with all speakers

4:55 PM

Adjourn

Loading...