WEBINAR
Only
Genome Integrity Discussion Group December 2021
Monday, December 6, 2021, 1:30 PM - 5:00 PM EST
Webinar
The greater New York metropolitan area is unparalleled in the concentration of world leading research on chromosome biology and function, as well as for research at the interface between chromosome integrity and the dynamics of malignancy. The Genome Integrity Discussion Group capitalizes on this concentration of excellence, providing a forum for interaction between basic- and clinically-oriented research groups working in these fields. These meetings facilitate synergy between labs, and provide a context in which previously unappreciated complementarities can be revealed.
In that spirit, the talks cover a broad range of areas including the DNA damage response and cancer predisposition, DNA replication, transcription, chromatin modification, recombination, cell cycle control, telomeres, chromosome segregation, epigenetic states, as well as the emergence of new technologies relevant to research in genome integrity. Although a primary focus is upon basic mechanisms and processes, these areas are pertinent to cancer and myriad human disease states.
Registration
Member
$5
Nonmember Academia, Faculty, etc.
$30
Nonmember Corporate, Other
$45
Nonmember Not for Profit
$30
Nonmember Student, Undergrad, Grad, Fellow
$10
Member Student, Post-Doc, Fellow
$0
Speakers
Britt Adamson, PhD
Princeton University
Carolina Reyes Batstia, PhD
Columbia University
Jean Gautier, PhD
Columbia University Irving Medical Center
Tuan Nguyen
Rockefeller University
David Schatz, PhD
Yale University
Richard Pomerantz, PhD
Thomas Jefferson University
Scientific Organizing Committee
Scott Keeney, PhD
Memorial Sloan Kettering Cancer Center
Jean Gautier, PhD
Columbia University Irving Medical Center
Susan Smith, PhD
New York University Langone Medical Center
Agata Smogorzewska, MD, PhD
The Rockefeller University
Alison Carley, PhD
New York Academy of Sciences
Genome Integrity Group Members
Related Content
Monday
December 06, 2021
1:30 PM
Welcome Remarks
1:40 PM
Mapping the Processes of DNA Repair That Impact Genome Editing
Speaker
Britt Adamson, PhD
Princeton University
2:10 PM
Targeting and DNA Repair During Immunoglobulin Somatic Hypermutation
Speaker
David Schatz, PhD
Yale University
2:40 PM
RNA Exosome Drives Early B cell Development via Noncoding RNA Processing Mechanisms
Speaker
Carolina Reyes Batista, PhD
Columbia University
2:55 PM
Break
3:10 PM
Eukaryotic Chromatin Attenuates the Forces Exerted by Sox2 Pioneer Transcription Factor on DNA Through Co-condensation
Speaker
Tuan Nguyen
The Rockefeller University
+ Abstract
Formation of biomolecular condensates constitutes an emergingly important mechanism of transcriptional regulation. Recent studies suggest that protein-DNA co-condensation can generate forces driving genomic arrangement. Nonetheless, the extent of mechano-regulation mediated by biomolecular condensates is not well understood, notably within the context of the chromatin. Using single-molecule techniques, we show that Sox2, a model pioneer factor implicated in the regulation of pluripotency, forms biomolecular condensates that exert forces in the order of ~5-7 pN with distinct mechanical effects on DNA in cis and in trans. Moreover, we show that chromatin components, such as nucleosomes and linker histone H1, colocalize with Sox2 and attenuate its force-induced mechanical effects on DNA. Together, our data suggest a mechanism wherein chromatin components can function as a sink to buffer the mechanical stress exerted by biomolecular condensates.
3:25 PM
New Mechanisms for DNA End-joining Polymerases
Speaker
Richard Pomerantz, PhD
Thomas Jefferson University
3:55 PM
Mechanisms of Transcription-coupled Genome Insertions
Speaker
Jean Gautier, PhD
Columbia University Irving Medical Center
4:25 PM
Q&A with all speakers
4:55 PM