Click here to learn about Academy events, publications and initiatives around COVID-19.

We are experiencing intermittent technical difficulties. At this time, you may not be able to log in, register for an event, or make a donation via the website. We appreciate your patience, and apologize for any inconvenience this may cause.

Our site is under planned maintenance. At this time, you will not be able to log in, register for an event, or make a donation via the website. We appreciate your patience, and apologize for any inconvenience this may cause.

Support The World's Smartest Network
×

Help the New York Academy of Sciences bring late-breaking scientific information about the COVID-19 pandemic to global audiences. Please make a tax-deductible gift today.

DONATE
This site uses cookies.
Learn more.

×

This website uses cookies. Some of the cookies we use are essential for parts of the website to operate while others offer you a better browsing experience. You give us your permission to use cookies, by continuing to use our website after you have received the cookie notification. To find out more about cookies on this website and how to change your cookie settings, see our Privacy policy and Terms of Use.

We encourage you to learn more about cookies on our site in our Privacy policy and Terms of Use.

Pulmonary Hypertension: Beyond Vasodilators

WEBINAR

Only

Pulmonary Hypertension: Beyond Vasodilators

Tuesday, October 12, 2021, 11:00 AM - 5:30 PM EDT

Webinar

Presented By

Biochemical Pharmacology Discussion Group

The New York Academy of Sciences

 

Pulmonary hypertension (PH) is a highly morbid condition without cure. Some forms of PH, such as Pulmonary Arterial Hypertension (PAH) have a mean survival of 5-years after diagnosis with mortality most commonly due to right heart failure. Current therapies include several classes of vasodilators, including prostacyclins, calcium channel blockers, PDE5 inhibitors, endothelin receptor antagonists (ETRA), and soluble guanylate cyclase stimulators, all of which are limited by systemic hypotension. Several agents including ETRA and prostacyclin have additional dose-limiting systemic side effects or toxicities. Moreover, many patients are unresponsive to these agents at diagnosis or during the course of therapy, due to advanced disease, progression, or drug tachyphylaxis. Given these limitations, there is a strong need for new therapies beyond vasodilators acting by novel anti-proliferative, anti­fibrotic, or anti-inflammatory mechanisms to modify the natural history of disease. This virtual symposium will convene basic researchers, clinicians, and drug developers to discuss latest advances in the development of novel therapeutics that can overcome the limitations of current therapy for PH.

Registration

Member
$30
Nonmember Academia, Faculty, etc.
$65
Nonmember Corporate, Other
$85
Nonmember Not for Profit
$65
Nonmember Student, Undergrad, Grad, Fellow
$45
Member Student, Post-Doc, Fellow
$15
Deadline:
0
days
left

Speakers

Naomi C. Chesler, PhD
Naomi C. Chesler, PhD

University of California, Irvine

Frances de Man, PhD
Frances de Man, PhD

VU University Medical Center, Amsterdam

Robert Lafyatis, MD
Robert Lafyatis, MD

University of Pittsburgh School of Medicine

Tim Lahm, MD
Tim Lahm, MD

Indiana University School of Medicine

Janethe Deolina Oliveira Pena, MD, PhD
Janethe Deolina Oliveira Pena, MD, PhD

Acceleron

Soni S Pullamsetti, PhD
Soni S Pullamsetti, PhD

Max Planck Institute for Heart and Lung Research

Paul B. Yu, MD, PhD
Paul B. Yu, MD, PhD

Harvard Medical School, Brigham and Women's Hospital

Jason Yuan, MD, PhD
Jason Yuan, MD, PhD

University of California, San Diego, School of Medicine

Scientific Organizing Committee

Yinglin Gao, PhD
Yinglin Gao, PhD

Regeneron Pharmaceuticals

Elena A. Goncharova, PhD
Elena A. Goncharova, PhD

University of California Davis

Scott MacDonnell, PhD
Scott MacDonnell, PhD

Regeneron Pharmaceuticals

Paul B. Yu, MD, PhD
Paul B. Yu, MD, PhD

Harvard Medical School, Brigham and Women's Hospital

Sonya Dougal, PhD
Sonya Dougal, PhD

The New York Academy of Sciences

Barbara Knappmeyer, PhD
Barbara Knappmeyer, PhD

The New York Academy of Sciences

Program Supporters

Tuesday

October 12, 2021

11:00 AM

Welcome Remarks

Speaker

Barbara Knappmeyer, PhD
The New York Academy of Sciences
11:10 AM

Conference Overview

Speaker

Speaker to Be Announced

Session 1: Vessel Remodeling: Molecular Mechanisms and Therapeutic Targets

Session Chairperson
Elena A. Goncharova, PhD
11:20 AM

Epigenetic Landscape of Pulmonary Hypertension: Emerging Therapeutic Avenue

Speaker

Soni S. Pullamsetti, PhD
Max Planck Institute for Heart and Lung Research
11:50 AM

Ion Channels as Drug Targets for Pulmonary Hypertension

Speaker

Jason Yuan, PhD
The University of California San Diego
12:20 PM

Single Cell Gene Expression in Idiopathic Pulmonary Arterial Hypertension

Speaker

Robert Lafyatis, MD
University of Pittsburgh, School of Medicine

Session 2: Short Talks and Poster Session

12:50 PM

Networking Lunch Break with Virtual Poster Session

1:50 PM

Short Talk 1 (Selected from Abstract Submissions)

2:05 PM

RV-specific Targeting of EndMT is a Potent Anti-fibrotic Therapy to Rescue Pulmonary Hypertension-induced Right Ventricular Failure​

Speaker

Somanshu Banerjee, PhD
UCLA
2:20 PM

Combination therapy using SERCA2a gene transfer with a novel STAT3 inhibitor, HJC0152, for treating pulmonary arterial hypertension

Speaker

Lahouaria Hadri, PhD
Icahn School of Medicine at Mount Sinai

Session 3: Emerging Therapies for Right Ventricular Dysfunction and Failure

2:35 PM

The Right Heart as Therapeutic Target in Pulmonary Hypertension

Speaker

Frances de Man, PhD
VU University Medical Center, Amsterdam
3:05 PM

Novel Therapeutic Strategies to Promote Right Ventricular Adaptation in Pulmonary Hypertension

Speaker

Tim Lahm, MD
Indiana University School of Medicine
3:35 PM

Pathways Regulating Right Ventricular Adaptation vs Decompensation

Speaker

Naomi C. Chesler, PhD
University of California, Irvine
4:05 PM

Break

Session 4: Pulmonary Hypertension Beyond Vasodilation: Clinical Practice

4:20 PM

Signaling Through the Receptors of the TGF-β Family: Impact on Vascular Remodeling and Cardiac Effects in PAH

Speaker

Paul Yu, MD, PhD
Brigham and Women's Hospital, Harvard Medical School
4:50 PM

Restoring Balance Between Activin and BMP Pathways in Pulmonary Hypertension​

Speaker

Janethe Deolina Oliveira Pena, MD, PhD
Acceleron Pharma
5:20 PM

Closing Remark

Speaker

Barbara Knappmeyer, PhD
The New York Academy of Sciences
5:25 PM

Conference Ends