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Neurodegeneration and Proteostasis

Neurodegeneration and Proteostasis

Monday, March 7, 2022, 8:30 AM - 6:00 PM EST

New York City

Presented By

The New York Academy of Sciences

AbbVie Inc

 

This symposium highlights translational research that targets protein homeostasis (proteostasis) to treat neurodegenerative diseases. It will bring together basic researchers in proteostasis biology and neurodegenerative diseases with clinicians, drug developers, and investors interested in biomedicine to discuss how the emerging understanding of the functioning of the proteostasis network components can be leveraged to benefit patients.

Topics include:

  • How do proteostasis pathways fail with aging and in neurodegenerative disease?
  • Are there potential contra-indications and undesired consequences of sustained activation of pathways aimed at restoring proteostatic function?
  • What are the challenges to developing proteostasis-directed therapies in the CNS?
  • What biomarkers are available or need to be developed to measure proteostasis in the clinic?
  • What are the current therapeutics entering clinical trials?
  • What are the challenges with systemic treatment in an elderly population?
Deadline:
0
days
left

Scientific Organizing Committee

Ana Maria Cuervo, MD, PhD
Ana Maria Cuervo, MD, PhD

Albert Einstein College of Medicine

Jeffery Kelly, PhD
Jeffery Kelly, PhD

The Scripps Research Institute

Matthew Townsend, PhD
Matthew Townsend, PhD

AbbVie Inc.

Sonya Dougal, PhD
Sonya Dougal, PhD

The New York Academy of Sciences

Barbara Knappmeyer, PhD
Barbara Knappmeyer, PhD

The New York Academy of Sciences

Speakers

Ana Maria Cuervo MD, PhD
Ana Maria Cuervo MD, PhD

Albert Einstein College of Medicine

Fiona Elwood, PhD
Fiona Elwood, PhD

Novartis Institutes for BioMedical Research

Steven Finkbeiner, MD, PhD
Steven Finkbeiner, MD, PhD

University of California, San Francisco

Judith Frydman, PhD
Judith Frydman, PhD

Stanford University

Katherine A. High, MD
Katherine A. High, MD

Ask Bio

Peter T. Lansbury, PhD
Peter T. Lansbury, PhD

Harvard University, Bial Biotech

Richard I. Morimoto, PhD
Richard I. Morimoto, PhD

Northwestern University

Ralph A. Nixon, MD, PhD
Ralph A. Nixon, MD, PhD

NYU Langone Health

David Rubinsztein, PhD
David Rubinsztein, PhD

University of Cambridge

Luke Wiseman, PhD
Luke Wiseman, PhD

The Scripps Research Institute

Ai Yamamoto, PhD
Ai Yamamoto, PhD

Columbia University

Richard J. Youle, PhD
Richard J. Youle, PhD

National Institute of Neurological Disorders and Stroke

Monday

March 07, 2022

8:15 AM

Continental Breakfast and Registration

9:00 AM

Welcome Remarks

Speakers

Sonya Dougal, PhD
New York Academy of Sciences
Matthew Townsend, PhD
AbbVie Inc
Ana Maria Cuervo, MD, PhD
Albert Einstein College of Medicine

Session 1: Basic Biology of Proteostasis as It Informs Drug Discovery

Session Chairperson
Ana Maria Cuervo, MD, PhD, Albert Einstein College of Medicine
9:20 AM

Proteostasis, Protein Conformation and Drug Discovery

Speaker

Richard Morimoto, PhD
Northwestern University
9:50 AM

Failure of Proteostasis in Neurodegenerative Disease

Speaker

David Rubinsztein, PhD
University of Cambridge, UK
10:20 AM

Cell and Molecular Biology of Neurodegeneration

Speaker

Judith Frydman, PhD
Stanford University
10:50 AM

Networking Coffee Break

11:20 AM

Panel Discussion: Which Pathways Should be Targeted?

Speakers

Moderator: Jeffery Kelly, PhD
The Scripps Research Institute
Panelist: Ana Maria Cuervo, MD, PhD
Albert Einstein College of Medicine
Panelist: Richard Youle, PhD
National Institute of Neurological Disorders and Stroke
Panelist: Ralph Nixon, MD, PhD
NYU Langone Health
Panelist: Ai Yamamoto, PhD
Columbia University
12:05 PM

Lunch / Poster Viewing

Session 2: Translational Research Approaches

Session Chairperson
TBD
1:30 PM

Using PROTACS to Treat Neurodegenerative Disorders

Speaker

Angela Cacace, PhD
Arvinas
2:00 PM

The Clinical Path for Gene Therapy Development

Speaker

Katherine High, MD
AskBio
2:30 PM

Targeting GCase for Parkinson's & Lysosomal Storage Disorders

Speaker

Peter Lansbury, PhD, Harvard University
Bial Biotech
3:00 PM

Investor Perspective

Speaker

Stacie Weninger, PhD
F-Prime Capital
3:30 PM

Networking Coffee Break

4:00 PM

Panel Discussion: What is Needed to Move into the Clinic?

Speakers

Moderator: TBD
Panelist: Fiona Elwood, PhD
Novartis Institutes for Biomedical Research
Panelist: Luke Wiseman, PhD
Scripps Research Institute
Panelist: Steven Finkbeiner, MD, PhD
University of California, San Francisco
Additional Panelist TBD
4:45 PM

Conference Takeaways and Summary

Speaker

Jeffery Kelly, PhD
The Scripps Research Institute
5:00 PM

Closing Remarks

Speaker

Sonya Dougal, PhD
New York Academy of Sciences
5:05 PM

Networking Reception / Poster Viewing

6:00 PM

Adjourn

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