
Neurodegeneration and Proteostasis
Monday, March 7, 2022, 8:30 AM - 6:00 PM EST
New York City
This symposium highlights translational research that targets protein homeostasis (proteostasis) to treat neurodegenerative diseases. It will bring together basic researchers in proteostasis biology and neurodegenerative diseases with clinicians, drug developers, and investors interested in biomedicine to discuss how the emerging understanding of the functioning of the proteostasis network components can be leveraged to benefit patients.
Topics include:
- How do proteostasis pathways fail with aging and in neurodegenerative disease?
- Are there potential contra-indications and undesired consequences of sustained activation of pathways aimed at restoring proteostatic function?
- What are the challenges to developing proteostasis-directed therapies in the CNS?
- What biomarkers are available or need to be developed to measure proteostasis in the clinic?
- What are the current therapeutics entering clinical trials?
- What are the challenges with systemic treatment in an elderly population?
Monday
March 07, 2022
Continental Breakfast and Registration
Welcome Remarks
Speakers
Session 1: Basic Biology of Proteostasis as It Informs Drug Discovery
Proteostasis, Protein Conformation and Drug Discovery
Speaker
Failure of Proteostasis in Neurodegenerative Disease
Speaker
Cell and Molecular Biology of Neurodegeneration
Speaker
Networking Coffee Break
Panel Discussion: Which Pathways Should be Targeted?
Speakers
Lunch / Poster Viewing
Session 2: Translational Research Approaches
Using PROTACS to Treat Neurodegenerative Disorders
Speaker
The Clinical Path for Gene Therapy Development
Speaker
Targeting GCase for Parkinson's & Lysosomal Storage Disorders
Speaker
Investor Perspective
Speaker
Networking Coffee Break
Panel Discussion: What is Needed to Move into the Clinic?
Speakers
Conference Takeaways and Summary
Speaker
Closing Remarks
Speaker