
Targeting Molecular Mechanisms of Aging
New York City
This event has been postponed and will be rescheduled for early 2023. Please check back soon for updates.
Aging is the strongest risk factor for many serious diseases and co-morbidities, including cancer, heart disease, kidney disease, dementia, Alzheimer’s disease, frailty, and sarcopenia. Increasing evidence suggests that aging occurs in a regulated manner and that perturbation of discrete cell-signaling pathways can extend lifespan and delay age-related diseases and co-morbidities. A number of key questions have surfaced through research efforts to better understand the molecular mechanisms underlying age-associated disease. For example, what are the triggers for age-induced changes? Which pathways are activated or suppressed as a result of age? How could counter-regulating these pathways be used to treat established diseases that are age-related, or to improve co-morbidities which are age-associated?
This conference will bring scientists together from across academia and industry to examine these questions through a keynote and plenary talks on modeling aging in different systems, biomarkers and molecular clocks, disease processes and other age-related diseases, epigenetics and germline mutations, proteostasis and senescence, and secreted factors and reprogramming. The concepts discussed in this symposium will help to drive work to improve treatments of age-related disorders.
Monday
February 07, 2022
WELCOME REMARKS
Speakers
KEYNOTE SPEAKER
Speaker
SESSION I: Modeling Aging in Different Systems
Tissue-specific Effects of Reduced Insulin Signaling on Ageing
Speaker
Effects of Aging on Muscle Stem Cells
Speaker
Break
Aging Gene Signatures
Speaker
What We Learn from Centenarians
Speaker
Lunch and Poster Session
Long-lived Mammals as Models to Discover Mechanisms of Longevity
Speaker
SESSION II: Biomarkers and Molecular Clocks
DNA Methylation Aging Clocks
Speaker
Translational Potential of the Biology of Aging
Speaker
Break
SESSION III: Disease Processes and Other Age-related Diseases
Sarcopenia as a Model Age-related Disorder
Speaker
Innovative Heterochronic Parabiosis and Brain Rejuvenation
Speaker
Closing Remarks, Day 1
End of Day
Tuesday
February 08, 2022
WELCOME REMARKS
Speaker
SESSION IV: Epigenetics and Germline Mutations
Molecular Mechanisms Determining Lifespan
Speaker
Functional Genomics of Aging
Speaker
SIRT6 activity and Lifespan
Speaker
Break
Chromatin Changes during Cellular Senescence and the Activation of Retrotransposable Elements in Aging
Speaker
The Polygenic Germline Contribution to Longevity
Speaker
SESSION V: Short Talks from Submitted Abstracts
Title to be announced
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Title to be announced
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Title to be announced
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Lunch and Poster Session
SESSION VI: Proteostasis and Senescence
Cellular Senescence in Brain Aging and Neurodegenerative Diseases
Speaker
Autophagy and Aging
Speaker
The Role and Regulation of the Autophagy In Aging and Age-Related Diseases
Speaker
Break
SESSION VII: Secreted Factors and Reprogramming
Organismal Rejuvenation Approaches
Speaker
The Molecular Basis of Systemic Communication, Perturbed by Aging
Speaker
Closing Remarks
Speaker