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Targeting Molecular Mechanisms of Aging

Targeting Molecular Mechanisms of Aging

Monday, February 7, 2022, 9:00 AM - Tuesday, February 8, 2022, 5:05 PM EST

7 World Trade Center, 250 Greenwich St Fl 40, New York

Presented By

The Biochemical Pharmacology Discussion Group

The New York Academy of Sciences

 

Registration Opening Soon


​Aging is the strongest risk factor for many serious diseases and co-morbidities, including cancer, heart disease, kidney disease, dementia, Alzheimer’s disease, frailty, and sarcopenia. Increasing evidence suggests that aging occurs in a regulated manner and that perturbation of discrete cell-signaling pathways can extend lifespan and delay age-related diseases and co-morbidities.  A number of key questions have surfaced through research efforts to better understand the molecular mechanisms underlying age-associated disease.  For example, what are the triggers for age-induced changes?  Which pathways are activated or suppressed as a result of age?  How could counter-regulating these pathways be used to treat established diseases that are age-related, or to improve co-morbidities which are age-associated?

This conference will bring scientists together from across academia and industry to examine these questions through a keynote and plenary talks on modeling aging in different systems, biomarkers and molecular clocks, disease processes and other age-related diseases, epigenetics and germline mutations, proteostasis and senescence, and secreted factors and reprogramming.  The concepts discussed in this symposium will help to drive work to improve treatments of age-related disorders.

Call for Abstracts

You are invited to submit a poster abstract to be considered for a virtual poster session and short talks. For submission instructions, please visit our online portal here. The deadline for abstract submission is December 7, 2021.

Scientific Organizing Committee

David Glass, MD
David Glass, MD

Regeneron Pharmaceuticals

Vera Gorbunova
Vera Gorbunova, PhD

University of Rochester

Pura Muñoz Cánoves
Pura Muñoz Cánoves, PhD

University Pompeu Fabra (UPF), CIBERNED, ICREA

Paola Sebastiani, PhD
Paola Sebastiani, PhD

Tufts Medical Center

Melanie Brickman Borchard
Melanie Brickman Borchard, MSc. PhD

New York Academy of Sciences

Keynote Presenter

Rafael de Cabo, PhD

National Institute on Aging, NIH

Speakers

Darren J. Baker
Darren J. Baker, PhD, MS

Mayo Clinic

Haim Cohen, PhD
Haim Cohen, PhD

Bar Ilan University

Ana Maria Cuervo
Ana Maria Cuervo, MD, PhD

Albert Einstein College of Medicine

Luigi Ferrucci
Luigi Ferrucci, PhD

National Institute on Aging, NIH

David Glass
David Glass, MD

Regeneron Pharmaceuticals

Vera Gorbunova
Vera Gorbunova, PhD

University of Rochester

Malene Hansen
Malene Hansen, PhD

The Buck Institute

Steve Horvath
Steve Horvath, PhD, ScD

University of California, Los Angeles (UCLA)

Juan Carlos Izpisua Belmonte
Juan Carlos Izpisua Belmonte, PhD

Salk Institute for Biological Studies

Pura Muñoz Cánoves
Pura Muñoz Cánoves, PhD

University Pompeu Fabra (UPF), CIBERNED, ICREA

Linda Partridge
Linda Partridge, DBE, FRS, FRSE, FMedSci

University College London and the Max Planck Institute for Biology of Ageing

Nicholas Schork
Nicholas Schork, PhD

The Translational Genomics Research Institute

Paola Sebastiani
Paola Sebastiani, PhD

Tufts Medical Center

John Sedivy, PhD
John Sedivy, PhD

Brown University

Andrei Seluanov
Andrei Seluanov, PhD

University of Rochester

Yousin Suh
Yousin Suh, PhD

Columbia University

Tea Shavlakadze
Tea Shavlakadze, PhD

Regeneron Pharmaceuticals

Saul Villeda
Saul Villeda, PhD

University of California, San Francisco (UCSF)

Tony Wyss-Coray
Tony Wyss-Coray, PhD

Stanford University

Monday

February 07, 2022

9:00 AM

WELCOME REMARKS

Speakers

Melanie Brickman Borchard, PhD, MSc
New York Academy of Sciences
David Glass, MD
Regeneron Pharmaceuticals
9:20 AM

KEYNOTE SPEAKER

Speaker

Rafael de Cabo, PhD
National Institute on Aging, NIH

SESSION I: Modeling Aging in Different Systems

Session Chairperson
Chairperson to Be Announced
10:00 AM

Tissue-specific Effects of Reduced Insulin Signaling on Ageing

Speaker

Linda Partridge, DBE, FRS, FRSE, FMedSci
University College London and the Max Planck Institute for the Biology of Ageing
10:30 AM

Effects of Aging on Muscle Stem Cells

Speaker

Pura Muñoz Cánoves, PhD
University Pompeu Fabra (UPF), CIBERNED, ICREA
11:00 AM

Break

11:30 AM

Aging Gene Signatures

Speaker

David Glass, MD
Regeneron Pharmaceuticals
12:00 PM

What We Learn from Centenarians

Speaker

Paola Sebastiani, PhD
Tufts Medical Center
12:30 PM

Lunch and Poster Session

1:45 PM

Long-lived Mammals as Models to Discover Mechanisms of Longevity

Speaker

Vera Gorbunova, PhD
University of Rochester

SESSION II: Biomarkers and Molecular Clocks

Session Chairperson
Chairperson to Be Announced
2:15 PM

DNA Methylation Aging Clocks

Speaker

Steve Horvath, PhD, ScD
University of California, Los Angeles (UCLA)
2:45 PM

Translational Potential of the Biology of Aging

Speaker

Luigi Ferrucci, PhD
National Institute on Aging, NIH
3:15 PM

Break

SESSION III: Disease Processes and Other Age-related Diseases

Session Chairperson
Chairperson to Be Announced
3:45 PM

Sarcopenia as a Model Age-related Disorder

Speaker

Tea Shavlakadze, PhD
Regeneron Pharmaceuticals
4:15 PM

Innovative Heterochronic Parabiosis and Brain Rejuvenation

Speaker

Saul Villeda, PhD
University of California, San Francisco (UCSF)
5:00 PM

Closing Remarks, Day 1

5:05 PM

End of Day

Tuesday

February 08, 2022

WELCOME REMARKS

Speaker

Melanie Brickman Borchard, PhD, MSc
New York Academy of Sciences

SESSION IV: Epigenetics and Germline Mutations

Session Chairperson
Chairperson to Be Announced
9:00 AM

Molecular Mechanisms Determining Lifespan

Speaker

Andrei Seluanov, PhD
University of Rochester
9:30 AM

Functional Genomics of Aging

Speaker

Yousin Suh, PhD
Columbia University
10:00 AM

SIRT6 activity and Lifespan

Speaker

Haim Cohen, PhD
Bar Ilan University
10:30 AM

Break

11:00 AM

Chromatin Changes during Cellular Senescence and the Activation of Retrotransposable Elements in Aging

Speaker

John Sedivy, PhD
Brown University
11:30 AM

The Polygenic Germline Contribution to Longevity

Speaker

Nicholas Schork, PhD
The Translational Genomics Research Institute

SESSION V: Short Talks from Submitted Abstracts

12:00 PM

Title to be announced

Speaker

Speaker to be selected
12:10 PM

Title to be announced

Speaker

Speaker to be selected
12:20 PM

Title to be announced

Speaker

Speaker to be selected
12:30 PM

Lunch and Poster Session

SESSION VI: Proteostasis and Senescence

Session Chairperson
Chairperson to Be Announced
1:45 PM

Cellular Senescence in Brain Aging and Neurodegenerative Diseases

Speaker

Darren J. Baker, PhD, MS
Mayo Clinic
2:15 PM

Autophagy and Aging

Speaker

Ana Maria Cuervo, MD, PhD
Albert Einstein College of Medicine
2:45 PM

The Role and Regulation of the Autophagy In Aging and Age-Related Diseases

Speaker

Malene Hansen, PhD
The Buck Institute
3:15 PM

Break

SESSION VII: Secreted Factors and Reprogramming

Session Chairperson
Chairperson to Be Announced
3:45 PM

Organismal Rejuvenation Approaches

Speaker

Juan Carlos Izpisua Belmonte, PhD
Salk Institute for Biological Studies
4:15 PM

The Molecular Basis of Systemic Communication, Perturbed by Aging

Speaker

Tony Wyss-Coray, PhD
Stanford University
5:00 PM

Closing Remarks

Speaker

Melanie Brickman Borchard, PhD, MSc
New York Academy of Sciences
5:05 PM

End of Day