• Academy Events

  • Epigenetics: Cancer and Beyond

    Thursday, April 28, 2016 | 9:00 AM - 5:00 PM
    The New York Academy of Sciences

    Presented by the Biochemical Pharmacology Discussion Group and the Cancer & Signaling Discussion Group

    Related Content

    Transcription of genetic information encoded in DNA is regulated by epigenetic processes that work in concert to affect chromatin structure. The process by which this occurs involves modification of chromatin by 'writers' that add post-translational modifications (such as acetylation) to amino acids present on histones. These modifications affect histone-DNA interactions, resulting in relaxation of chromatin and recruitment of proteins required for transcription. A key example of these epigenetic 'readers' are the bromodomain extra-terminal (BET) family which bind acetylated lysines found on histones in DNA coding sequences, mobilizing transcriptional machinery to these sites, and thus activating gene expression.

    Importantly, epigenetic processes are widely accepted to play an important role in cancer, and BET proteins in particular have been heavily implicated in tumorigenesis by upregulating expression of oncogenic genes. BET proteins also have important roles in immune biology, cell growth, and differentiation. These roles underscore the therapeutic potential of targeting epigenetics for the treatment of complex disorders and bromodomain inhibitors, most notably those targeting BET families, have emerged as strong candidates. The objective of this symposium is to explore the therapeutic potential of pharmacologic modulation of the epigenome.

    Registration Pricing

    Member $60
    Member (Student / Postdoc / Resident / Fellow) $25
    Nonmember (Academia) $105
    Nonmember (Corporate) $160
    Nonmember (Non-profit) $105
    Nonmember (Student / Postdoc / Resident / Fellow) $70

    This event will also be broadcast as a webinar; registration is required.

    Please note: Transmission of presentations via the webinar is subject to individual consent by the speakers. Therefore, we cannot guarantee that every speaker's presentation will be broadcast in full via the webinar. To access all speakers' presentations in full, we invite you to attend the live event in New York City where possible.

    Webinar Pricing

    Member $30
    Member (Student / Postdoc / Resident / Fellow) $15
    Nonmember (Academia) $65
    Nonmember (Corporate) $85
    Nonmember (Non-profit) $65
    Nonmember (Student / Postdoc / Resident / Fellow) $45


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