Phosphatidylserine (PS) is a membrane lipid that regulates multiple biological processes. It is normally positioned in the inner leaflet of the plasma membrane but translocates to the outer, extracellular-facing surface to signal clearance of apoptotic cells, to quell unwanted inflammatory reactions and immunity, and to stimulate hemostasis and complement activation at sites of injury. PS exposure can be subverted by cells that become malignant or infected by viruses as a ploy to escape host defenses. This symposium will highlight recent developments in the understanding of PS regulation and its exploitation to create novel therapeutics for cancer and viral diseases. Alan Schroit (UT Southwestern) will introduce the topic and discuss how PS asymmetry is regulated in resting cells and the physiologic and pathologic consequences of its loss. David Ucker (University of Illinois at Chicago) will describe how PS exposure suppresses inflammatory and immune responses to cells undergoing apoptosis at the end of their natural lifespan. Ari Helenius (ETH Hönggerberg) will discuss how viruses use macropinocytosis and apoptotic mimcry to enter host cells. Chris Reutelingsperger (University of Maastricht) will discuss the use of annexin A5 to image apoptosis for detecting cardiopulmonary lesions and monitoring tumor responses to therapy. He will also discuss the use of annexin A5 for drug delivery. Finally, Philip Thorpe (UT Southwestern) will discuss clinical trials with bavituximab, an antibody that targets PS-expressing tumor vasculature and reactivates host immunity.
This event will also be broadcast as a webinar.
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