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Progressive Multifocal Leukoencephalopathy (PML) is, in the general population, a rare but serious demyelinating disease of the brain, often resulting in severe disability or death and is caused by infection of oligodendrocytes by the JC polyomavirus (JCV). It is believed that fifty to sixty percent of the population is sero-positive for JCV, indicating exposure to the virus. Despite the high prevalence of JCV infection in the human population, which typically leads to a chronic, asymptomatic infection, incidence of PML in the general population is very low. The pathogenesis of PML is not well understood. It is believed that the development of PML, while dependent on the presence of JCV, is the result of a confluence of viral and host risk factors, which may include an altered or compromised immune system such as in individuals with HIV-1 infection/acquired immune deficiency syndrome (AIDS), or patients undergoing chronic immunosuppressive therapies after organ transplantation, for treatment of lymphomas, or for autoimmune conditions, such as MS.
This 2-day conference will bring together basic science researchers, clinicians, physicians, epidemiologists, and regulatory experts from academia, industry, and government to address novel issues, current challenges, and future directions of basic and clinical research relevant to the mitigation, potential future cure, and risk stratification of PML. Topics of discussion will include JCV virology, PML pathogenesis, risk stratification and disease diagnosis and management. The meeting will feature a series of plenary lectures, short talk presentations selected from submitted abstracts, a poster session, and a closing panel discussion.
Conference Planning Committee
Claudio Carini, MD
Pfizer Inc.
Teresa Compton, PhD
Biogen Idec (Conference Chair)
Marion Kasaian, PhD
Pfizer Inc.
Theodora Salcedo, PhD
Bristol-Myers Squibb Company
Anne Vogt, PhD
F. Hoffmann-La Roche Ltd
Scientific Advisory Board
Leonard H. Calabrese, DO
Cleveland Clinic
Paola Cinque, MD, PhD
San Raffaele Scientific Institute
David B. Clifford, MD
Washington University School of Medicine
Robert L. Garcea, MD
University of Colorado at Boulder
Eugene O. Major, PhD
National Institute of Neurological Disorders and Stroke
Kenneth Tyler, MD
University of Colorado School of Medicine
Thomas Weber, MD
University of Hamburg
Registration Pricing
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By 5/13/2013 |
After 5/13/2013 |
Onsite |
| Member |
$125 |
$150 |
$175 |
| Student/Postdoc Member |
$75 |
$100 |
$125 |
| Nonmember (Academia) |
$150 |
$185 |
$225 |
| Nonmember (Corporate) |
$185 |
$225 |
$265 |
| Nonmember (Non-profit) |
$150 |
$185 |
$225 |
| Nonmember (Student / Postdoc / Fellow) |
$75 |
$100 |
$125 |
Registration includes a complimentary, one-year membership to the New York Academy of Sciences. Complimentary memberships are provided to non-members only and cannot be used to renew or extend existing or expiring memberships. A welcome email will be sent upon registration which will include your membership credentials.
Presented by
Agenda
* Presentation titles and times are subject to change.
Day 1: June 19, 2013
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8:00 AM
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Breakfast and Registration
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8:45 AM
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Welcoming Remarks Brooke Grindlinger, PhD, The New York Academy of Sciences Teresa Compton, PhD, on behalf of the PML-Consortium
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9:00 AM
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Keynote Address: Natalizumab-associated PML Alfred Sandrock, Jr., MD, PhD, Biogen Idec, Inc.
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Session 1: JCV Virology
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Thomas Weber, MD, Marienrankenhaus Hamburg Tina Dalianis, MD, PhD, Karolinska Institutet |
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9:45 AM
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Infectious Entry of JCPyV into Host Cells Walter J. Atwood, PhD, Brown University
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10:15 AM
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Leu/Ile/Phe-rich Domain of JC Virus Agnoprotein Plays Important Regulatory Roles in Dimer/Oligomer Formation, Protein Stability and Splicing of The Viral Transcripts Mahmut Safak, PhD, Temple University School of Medicine
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10:45 AM
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Networking Break
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11:15 AM
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Virion Assembly Factories in Polyoma-Infected Cells Robert L. Garcea, MD, University of Colorado, Boulder
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11:45 AM
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Short Talk 1 — Selected from Submitted Abstracts
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12:00 PM
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Short Talk 2 — Selected from Submitted Abstracts
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12:15 PM
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Short Talk 3 — Selected from Submitted Abstracts
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12:30 PM
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Networking Lunch
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1:30 PM
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Patient Keynote Address: A Patient and Family Perspective on PML Declan R. Walsh, Deferno Trust
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Session 2: Pathogenesis
| Co-Chairs: |
Kenneth Tyler, MD, University of Colorado School of Medicine Leonard H. Calabrese, DO, Cleveland Clinic |
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2:00 PM
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Immunology of PML Roland Martin, MD, University of Zürich
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2:30 PM
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Viral Determinants of PML Pathogenesis Leonid Gorelik, PhD, Biogen Idec Inc.
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3:00 PM
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Networking Break
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3:30 PM
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Virus-Host Interactions — Lessons from the BK Virus Hans H. Hirsch, MD, MSc, University of Basel, Switzerland
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4:00 PM
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T Lymphocyte-mediated Cellular Immune Response against JC Virus in PML Patients Igor J. Koralnik, MD, Beth Israel Deaconess Medical Center, Harvard Medical School
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4:30 PM
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Short Talk 4 — Selected from Submitted Abstracts
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4:45 PM
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Short Talk 5 — Selected from Submitted Abstracts
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5:00 PM
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Short Talk 6 — Selected from Submitted Abstracts
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5:15 PM
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Poster Session and Networking Reception
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7:00 PM
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Day 1 Close
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Day 2, June 20, 2013
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8:00 AM
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Breakfast
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8:45 AM
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Welcoming Remarks Teresa Compton, PhD, on behalf of the PML-Consortium
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Session 3: Risk Stratification
| Co-Chairs: |
Justin McArthur, MBBS, MPH, Johns Hopkins University School of Medicine Richard A. Rudick, MD, Cleveland Clinic
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9:00 AM
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Are B-cells a Reservoir of JC Virus? Raphael P. Viscidi, MD, Johns Hopkins University School of Medicine
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9:30 AM
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What Have We Learned From Natalizumab and PML Risk Stratification? Gary Bloomgren, MD, Biogen Idec Inc.
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10:00 AM
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Risk Stratification in the MS Patient Population Heinz Wiendl, MD, University of Münster
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10:30 AM
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Networking Break
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11:00 AM
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Short Talk 7 — Selected from Submitted Abstracts
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11:15 AM
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Short Talk 8 — Selected from Submitted Abstracts
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11:30 AM
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Short Talk 9 — Selected from Submitted Abstracts
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11:45 PM
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Short Talk 10 — Selected from Submitted Abstracts
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12:00 PM
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Networking Lunch
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Session 4: Diagnosis & Management of PML
| Co-Chairs: |
Paola Cinque, MD, PhD, San Raffaele Scientific Institute Joseph R. Berger, MD, University of Kentucky College of Medicine
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1:30 PM
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Immune Reconstitution Inflammatory Syndrome Avindra Nath, MD, National Institute of Neurological Disorders and Stroke
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2:00 PM
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Magnetic Resonance Imaging Findings in Progressive Multifocal Leukoencephalopathy in Natalizumab-Treated MS Patients Nancy D. Richert, MD, PhD, Biogen Idec Inc.
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2:30 PM
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PML Clinical Trials David B. Clifford, MD, Washington University School of Medicine
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3:00 PM
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Pathology of Immune Reconstitution Inflammatory Syndrome in Multiple Sclerosis With Natalizumab-Associated Progressive Multifocal Leukoencephalopathy Imke Metz, MD, University Medical Center, Georg-August-Universität Göttingen
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3:30 PM
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Networking Break
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4:00 PM
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Short Talk 11 — Selected from Submitted Abstracts
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4:15 PM
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Short Talk 12 — Selected from Submitted Abstracts
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Session 5: Closing Session
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4:30 PM
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JCV and PML: Studies at the Intersection of the Immune and Nervous Systems Eugene O. Major, PhD, National Institute of Neurological Disorders and Stroke
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4:40 PM
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Panel Discussion: The Future of PML Moderator: Eugene O. Major, PhD, National Institute of Neurological Disorders and Stroke Panelists: Thomas Weber, MD, Marienrankenhaus Hamburg Paola Cinque, MD, PhD, Hospital San Raffaele Justin McArthur, MBBS, MPH, Johns Hopkins University School of Medicine Kenneth Tyler, MD, University of Colorado School of Medicine
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5:30 PM
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Conference Adjourns
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Travel & Lodging
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The New York Academy of Sciences
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