Aging is the strongest risk factor for many serious diseases and co-morbidities, including cancer, heart disease, kidney disease, dementia, Alzheimer’s disease, frailty, and sarcopenia. Increasing evidence suggests that aging occurs in a regulated manner and that perturbation of discrete cell-signaling pathways can extend lifespan and delay age-related diseases and co-morbidities. A number of key questions have surfaced through research efforts to better understand the molecular mechanisms underlying age-associated disease. For example, what are the triggers for age-induced changes? Which pathways are activated or suppressed as a result of age? How could counter-regulating these pathways be used to treat established diseases that are age-related, or to improve co-morbidities which are age-associated?
This conference will bring scientists together from across academia and industry to examine these questions through a keynote and plenary talks on modeling aging in different systems, biomarkers and molecular clocks, disease processes and other age-related diseases, epigenetics and germline mutations, proteostasis and senescence, and secreted factors and reprogramming. The concepts discussed in this symposium will help to drive work to improve treatments of age-related disorders.
