Summary
Dr Lynne Maquat of the University of Rochester and Dr. Alexander Varshavsky of the California Institute of Technology have been awarded the prestigious 2024 Dr. Paul Jannsen Award for their fundamental discoveries in the regulated degradation of RNAs and proteins. Dr. Maquat’s research has unveiled how cells selectively destroy flawed messenger RNA molecules to prevent the production of abnormal proteins. Dr. Varshavsky’s work uncovered key aspects of the ubiquitin system, including the first degradation signals (degrons) in short-lived proteins. Together, their collective discoveries have profoundly advanced our understanding of cellular mechanisms, opening avenues for new treatments for many human diseases such as cystic fibrosis, cancer, neurodegeneration, and disorders of immunity. This virtual symposium will celebrate their pioneering work. Symposium registration is complimentary. However, pre-registration is required for both in-person and virtual participation.
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