The barriers of the brain play a critical role in protecting the brain from toxic and infectious agents while maintaining the ionic and volumetric environments. However, the Blood-Brain Barrier and Blood-Cerebrospinal Fluid Barrier can also create an obstacle to effective drug delivery. This symposium will review the recent advances regarding the biology and therapeutic exploitation of these two barrier systems. The first portion will deal with the unique biological properties of these barriers in health and disease, specifically covering gene expression of the endothelium and its regulation by glia. The second portion will concentrate on novel approaches to drug delivery across the barriers and focus on brain penetration of large molecules, advances in nanoparticles and adenoviral vectors, and the emerging use of ultrasound. All together, these presentations will highlight fundamentals of the brain barriers and elaborate several key approaches for therapeutically breaching these barriers.
Call for Poster Abstracts
The deadline for abstract submission has been extended to Friday, October 14, 2011. For complete abstract instructions, please send an e-mail to BrainBarriers@nyas.org with the words "Abstract Information" in the subject line. There is no need to type a message: instructions will be forwarded automatically. For questions, please call 212.298.8611.
|Student / Postdoc / Fellow Member
|Student / Postdoc / Fellow Nonmember
|Nonmember Not for Profit
Image credit: The Blood-Brain Barrier Laboratory, University of Connecticut Health Center