This two-day scientific conference will provide a neutral forum to critically examine the traditional role of pre-clinical animal models in drug discovery, how these models most effectively contribute to translational medicine and drug discovery, changes needed to increase the predictive power of various models for drug efficacy in humans, and ways in which to further refine, reduce, and replace animal models in biomedical research.
By convening multidisciplinary clinical and basic science investigators, we hope to identify common hurdles and pathways to improving model systems for the evaluation of therapeutic efficacy and toxicity in the areas of metabolic and cardiovascular disease, inflammation, and pain, among others. Sessions on the recent explosion of broadly applicable new technologies in bioimaging, biosimulation, bioinformatics, generating genetically modified animals, and phenotype screening, along with emerging non-rodent models, the use of embryonic stem cells, patient-specific induced pluripotent stem cells, and humanized animal models will ensure that recent advances in basic science knowledge gained from improved pre-clinical animal models with good predictive validity readily become available to the pharmaceutical industry and clinical researchers so as to aid the discovery and development of new disease treatments as quickly as possible.
|Student / Postdoc / Fellow Member
|Student / Postdoc / Fellow Nonmember
|Nonmember Not for Profit
The Global Medical Excellence Cluster (GMEC)
Funding for this conference was made possible by the Office of the Director of the National Institute of Environmental Health Sciences and grant number R13RR032638 from the National Center for Research Resources, National Institute of General Medical Sciences, and National Institute of Diabetes and Digestive and Kidney Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services, nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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