Skip to main content

In Step with the UN on Science for Sustainable Development

Flags for different countries flying outside of the United Nations.

How ISR can help in fast-moving crises to protect progress on the UN Sustainable Development Goals.

Published November 15, 2022

By ISR Staff
Academy Contributor

For a United Nations discussion of the role of science in solving the world’s most urgent problems, the International Science Reserve (ISR) convened a panel of experts from the ISR network, across academic, private and public sectors. The recording is now available on-demand (viewing instructions below). 

The panel was moderated by Mila Rosenthal, Executive Director of the International Science Reserve, and included:  

  • Nicholas Dirks, President & CEO, New York Academy of Sciences, ISR Executive Board Co-chair 
  • Erwin Gianchandani, Assistant Director for Technology, Innovation and Partnerships National Science Foundation, Federal Liaison to the ISR 
  • Tracy Marshall, University of the West Indies St. Augustine Campus. Trinidad and Tobago, ISR Science Community Member 
  • Philip Nelson, Director, AI for Social Good, Google AI, ISR Executive Board Member 

The webinar was part of the United Nations General Assembly’s Science Summit, where we discussed how the ISR can help in fast-moving climate and health-related crises to protect progress on the UN Sustainable Development Goals – the Global Goals – and limit the damage to communities and habitats.

Mila Rosenthal (ISR) introduces the Sustainable Development Goals (SDGs) and their relationship to crises.

When a crisis hits, the International Science Reserve will help scientists in our network get additional access to specialized human and technical resources, like remote sensing, geospatial mapping and high-performance computing, so that they can apply their research for crisis response.

Here are two big takeaways from the discussion:

1. Human networks are key, and they need to include everyone to make sure that science and technology is aimed at helping the most vulnerable people and most fragile environments.

Erwin Gianchandani (NSF) on how the ISR democratizes access to resources.
Philip Nelson (Google AI) on the power of coming together.
Tracy Marshall (University of the West Indies – St. Augustine Campus) on how the ISR will support her work as a scientist. 

2. You can’t just throw money at a crisis and expect rapid response solutions.  You have to learn from previous experiences and prepare in advance. 

For example, the ISR is keeping the life-saving public-private connections made during COVID-19 alive in order to prepare for the next crisis. 

Erwin Gianchandani (NSF) on why networks are just as important as money in times of crisis research.
Nicholas Dirks (NYAS) on collaboration between the public and private sector during crisis.
Tracy Marshall (University of the West Indies – St. Augustine) on valuing local contexts in disaster management research. 
Philip Nelson (Google AI) on solving crisis-related problems in an open environment. 

— 

Do you want to watch the whole webinar? Here are three steps to rewatch the panel through the ISR Science Unusual series on-demand:   

  • Register for the webinar using this link  
  • Then, click “Join Event”  
  • After logging in, select the “Schedule” menu, or the grid menu (small squares) on mobile, located at the top of your screen, then click “On Demand” 

Scientists Hunt for Clues to Post-Wildfire Recovery in Argentina  

A researcher pours a liquid into a breaker containing a soil sample.

In August, wildfires left lasting economic damage while scorching forests and pastureland.

Published September 23, 2022

By ISR Staff
Academy Contributor

In August, wildfires ripped through the Córdoba Province in central Argentina, leaving economic damage and scorched forests and pastureland in its wake. Argentina is no stranger to wildfires, but climate change is making the fires more frequent, widespread and complex – and the impacts of drought and fires are stretching across borders.  

After thousands of acres in northern Argentina burned in February of 2022, ash clouds flew into Argentina’s neighbor, Paraguay, harming local residents’ health with smog-filled air. The country made international headlines just two years prior when another set of fires in Córdoba burned 60,000 hectares of flora, fauna, grassland, forests, and homes.  

Studying Changes to Soil Properties

Healthy farmland and soil are critical to the region, given that it relies heavily on its agricultural industry, like cattle farming. Crisis after crisis has forced the region’s leading scientists to rethink how fire-driven changes to soil properties implicates vegetation, plant regeneration and ecosystem services. And it has pushed them to work together across borders and scientific disciplines.  

“In late September 2020, it was easy to see from the Córdoba City the thick black plumes of smoke rising from the ranges, while hellish images were shown on TV and social media,” said Dr. Maria Gabriela Garcia, International Science Reserve community member and a geologist based in Córdoba. “This situation led me to wonder to what extent the fires have altered the chemical and physical properties of the soils, and ultimately, impacted their fertility and runoff control capacity.” 
 
After the 2020 fires, Argentina’s National Council of Science and Technology (CONICET) called researchers together from different disciplines to propose actions and lines of research that deal with different aspects of this crisis. Today, geologists, mineralogists, chemists, microbiologists and ecologists, are all working all together to rapidly characterize the dynamics of post-fire recovery.  

On the Hunt for Stronger Data

One unique collective of Argentinian scientists are on the hunt for stronger data about the soil in the aftermath of extreme wildfires. Through the NCST, Dr. Estela Cecilia Mlewski, a microbiologist, met Dr. Garcia, a professor at the National University of Córdoba. 

The team also brought on Edith Filippini, a lichenologist focused on ecological studies and biomonitoring of environments affected by fire; Romina Cecilia Torres – a specialist in postfire regeneration by resprouting and seedlings; and Daihana Argibay – a specialist in satellite image analysis. 

The group’s collected data will be fundamental to understanding the geochemical and microbiological disturbances that occur in soils of a semi-arid mountainous area of southern South America affected by forest fires, and help researchers design effective strategies for remediation of the affected ecosystems across the region. If their research can find the presence of microorganisms, for example, there is an opportunity for regrowth and regeneration of local flora – which could lessen the fires’ impact on farming or other ecological or economic activities. 

The Utility of the International Science Reserve

The group recently worked together on the International Science Reserve’s readiness exercise on wildfires. The ISR conducts readiness exercises – or scenarios – to bring scientists from across borders and disciplines together to prepare for crisis. The Argentinian scientists believe that the International Science Reserve can be useful for giving researchers the tools for fire prevention and support through much needed resources to predict fire behavior, and help in control and monitoring tasks against a crisis.  

“The ISR is an excellent opportunity to know researchers around the world working on similar aspects to us. It gives us the potential to generate collaborations between foreign groups and enrich our knowledge. The ISR’s readiness exercises can improve existing tools and more importantly, expand our ideas,” Dr. Mlewski recently told the ISR team in an interview. 

If you are interested in joining the International Science Reserve network and collaborating with scientists like the Argentinian group, please visit our sign-up page to learn more about becoming a member of the ISR community. 

A New Administration and a Renewed Investment in STEM

Alondra Nelson and Nicholas Dirks discuss the priorities for the Biden-Harris Administration’s Office of Science and Technology Policy.

Published December 23, 2021

By Roger Torda
Academy Contributor

Alondra Nelson

Alondra Nelson, at The New York Academy of Sciences’ (the Academy’s) recent Annual Meeting, told an audience of Academy Members that science, like representative government, is always a work-in-progress. “There’s an interesting parallel between scientific research and democracy in the sense that they both are never quite realized, never quite finished, never quite perfected,” said Nelson, a sociologist who serves as the inaugural Deputy Director for Science and Society in the White House Office of Science and Technology Policy (OSTP). She recently joined Academy President Nicholas Dirks for a virtual discussion titled “Renewed Investment in STEM.”

Nelson is a Professor at the Institute for Advanced Study in Princeton, New Jersey. Nelson’s earlier positions include President of the Social Science Research Council, an international research nonprofit organization, professor of sociology at Columbia University, and Columbia’s dean of social science. She has an extensive record of research on issues at the intersection of science, technology, and society.

“I have always been interested in race and racism and social inequality,” she said in her conversation with Dirks. “I’m particularly interested in how new and emerging technologies impact, for good and for bad, vulnerable communities…So that really has, I think, forged the experience that I brought into public service, this conviction that science and technology are inherently social things, and that when they enter the world, they do social things, they do political things.”

The Promise of Science and Technology

Nelson’s PhD dissertation at New York University grew into her first book, Body and Soul, about the Black Panther Party’s health activism in the late 1960s, especially its use of newly-available genetic screening tests for sickle cell anemia. “This new technology allowed a social movement to do these tests in the park and in auditoriums,” Nelson said. “It was really a new technology, SICKLEDEX, introduced in 1968, that allowed all of these social possibilities to happen around it, and allowed what we would call today ‘patient advocacy’ around a genetic disease.”

In her second book, The Social Life of DNA, Nelson was one of the first social scientists to write about direct-to-consumer genetic testing. The approach reflected her interests in inequality, the empowerment of communities, and the way communities make use of new technologies. As she told Dirks, the book explores complex issues in genetic genealogy, including how African Americans who are descendants of slavery can “use these technologies to try to look back to the past and … complete genealogical stories about themselves and about their families.” She said these new technological and scientific points in history are opportunities to think about how science and technology can “make our lives safer, better, fairer, more just.”

The Interplay of Science and Community

Nelson suggests that an awareness of the interplay of science and community is historically necessary and especially important right now:

[T]he Biden-Harris administration [faced] … some pretty pronounced crises, all of which have something to do with science and technology…There was this-once-in-a-century pandemic that’s still raging all around us. We’re obviously in the middle of a climate emergency…There’s a complex set of national security threats…ransomware attacks and cyber security issues…and then issues around injustice and inequity throughout society. Health outcomes during the pandemic, educational outcomes, and sort of everything in between.

Later in the discussion, Nelson used a campaign slogan of President Biden’s to frame this critical moment: “What does it mean to do science, and science and technology policy, in a way that ‘builds back better’?”

The answer, Dr. Nelson suggests, includes the recognition that hard science alone cannot do the job:

“It was amazing that we had SARS-CoV-2 decoded, the genome, in less than a month. And wow, it was like earth shattering and incredible that we had in 313 days, 314 days, a viable vaccine…[yet] we’ve spent all of the rest of the time trying to get people to use it…So, it was clear that social science, social issues, thinking about inequality, was going to have to be a course. And we had the…incredible, tragic disparities around race, around ethnicity, and immigration status, with regard to rates of people perishing.”

Reframing How We Think About the World

Nelson pointed out that her boss, Eric Lander, is the first Director of OSTP whose work has been in the life sciences, and that this is helping focus the Office’s work on healthcare issues, including pandemic preparedness. Nelson also described the value of the administration’s proposed ARPA-H agency, designed to fund advanced research projects to improve healthcare capabilities and platforms. She said this approach can support research in maternal health, maternal mortality rates, and behavioral science.

Nelson and Lander are also tackling problems resulting from bias in artificial intelligence data sets that can lead to discrimination in housing, employment, and healthcare. They are calling on the public to submit information about biometric technologies that might support a new “AI Bill of Rights.”

Amid global challenges and crises, Nelson seems optimistic. She refers to President Biden’s belief that difficult moments can lead to “promise and possibility” rather than peril. And she said of her own goals: “I really want to challenge folks in industry, folks in academia, to think about upstream issues, and to think about equity and justice, and safety in science and technology, as a kind of ‘innovation’, and to reframe how we think about that word.”

Nicholas Dirks used the occasion of the Academy’s Annual Meeting to outline plans for the International Science Reserve (ISR), a collaboration with IBM and other stakeholders to mobilize scientific communities to respond to global crises.

Do you want to be part of this impactful network of scientists? Join the ISR today

NYC Teacher Brings STEM to Her Social Studies Class

A woman poses for the camera with NYC's Brooklyn Bridge in the background.

Servena Narine, who teaches at a New York City public school in Brooklyn, uses science, technology, engineering, and math (STEM) skills to help her elementary school students master their social studies curriculum.

Published November 2, 2020

By Roger Torda
Academy Contributor

This summer, Narine used time made available because of the COVID-19 shutdown to take The New York Academy of Sciences’ online course STEM Education in the 21st Century. During the eight-week course, she designed a curriculum for fourth-grade students. One of the units called for students to use data analytics in creating an infographic to “tell a story about the effects of immigration on New York City’s industrial growth in the 1900s.”

The Seven Essential STEM Skills

Servena Narine outside her classroom at PS 307 in Brooklyn

“It was a course where we incorporated seven essential STEM skills into our teaching,” Narine said in a recent phone interview. “I think sometimes as teachers we do that naturally, but through the course I was able to more deeply integrate the STEM skills into my lesson plans.”

Narine was referring to seven skills Identified by the Academy’s STEM Education Framework. critical thinking, problem solving, creativity, communication, collaboration, data literacy, and digital literacy and computer science. These skills form the foundation of the course.

“The Academy developed its Framework back in 2016 as a research-based tool that can be used to ensure students receive high-quality STEM learning,” said Chris Link, the Academy’s Director of Education. “Our online course coaches teachers on strategies they can use to help their students build critical 21st-century skills.”

“Eight years ago, my school became a magnet school for STEM studies,” Narine explained, referring to PS 307, which serves pre-K through fifth grade in the Vinegar Hill neighborhood of Brooklyn. “I’m always looking to learn more about what it means to be a STEM school, and what it means to integrate the principles of STEM into the classroom. When I saw that this course was available, and that it was free, and that I had time on my hands because everyone was self-isolating because of COVID-19, I jumped right into it.”

Continuing Teacher and Leader Education

Narine was one of 100 New York City teachers enrolled in the course through the sponsorship of Medidata, which has supported several Academy STEM programs. Narine and other teachers who completed the course received 30 Continuing Teacher and Leader Education (CTLE) credits required by New York State to maintain certification.

“I loved that the course was asynchronous, so I could set a schedule for myself,” Narine said. “The participants, the other teachers, all reviewed each others’ work, and offered feedback. That was a great benefit. And I loved that for each of the seven skills there was an expert in the field who was able to share information.

Narine’s course not only incorporated STEM skills, but aligned closely with the state’s Passport to Social Studies curriculum. To develop critical thinking skills, one of her units calls on students to analyze documents from the Colonial and Revolutionary War periods. A unit on problem solving asks students to develop solutions to clashes between Native Americans and colonists.

Cross-Interdisciplinary Skills for Students

A unit on the geography of New York calls for creativity in designing maps to promote tourist destinations. Yet another unit is designed to promote collaboration skills as teams make a game to test knowledge of material covered in earlier units. These cross-disciplinary skills serve students in their social studies classes, their STEM classes, and beyond.

“The curriculum asks students to look at Native Americans as the first inhabitants of New York State,” Narine said, explaining how she started thinking about a unit that would focus on communication skills, another area of focus in the Academy’s online course.

“I remember thinking that we’d be learning about Native Americans in the region around the time we’d be celebrating Thanksgiving,” she continued. “And I thought it would be nice to have the children create a public service announcement to give thanks to Native Americans for the contributions they have made to New York State and to our society, rather than the other way around, where we pretty much look at the European influence and teach that it is because of the Europeans that we have Thanksgiving. I said, ‘Let’s turn it around and say thank you to the first inhabitants of New York for their contributions.’”

Devising New Therapies Across Borders

Award winners pose together with their trophies.

When Japanese physicist Kumiko Hayashi of Tohoku University and neuroscientist Ephraim Trakhtenberg of the University of Connecticut met at the New York Academy of Sciences this year, the synergies between their work weren’t immediately obvious.

Published October 1, 2017

By Hallie Kapner
Academy Contributor

The two scientists were paired together as part of the Interstellar Initiative, a joint project of the Academy and the Japan Agency for Medical Research and Development (AMED), which grouped 50 early-career scientists from around the world for interdisciplinary research projects.

“The biggest global challenges, whether in health, the environment, or energy, require scientists with different expertise to work together,” said Academy President & CEO Ellis Rubinstein. “The Interstellar Initiative brings together brilliant young scientists who would likely never cross paths, and supports them as they develop solutions to major health issues.”

Devising New Therapies

Hayashi and Trakhtenberg are devising new therapies to restore neuronal function following injury. As human cells mature, their ability to replicate is severely reduced. This phenomenon is especially prevalent in the brain, where the creation of new neurons exists only at very low levels in adulthood. Trakhtenberg’s work suggests that motor proteins may be involved in this loss.

“If we can understand the dynamics of these proteins, we may be able to reverse the process,” he said. Over the past several years, Hayashi developed novel algorithms that can be applied to motor protein measurement and analysis. “I don’t know much about neuroscience,” she said, “but it turns out that my algorithms can illuminate some mechanisms of the brain.”

From left to right: President Suematsu, Japan Agency for Medical Research and Development (AMED), recognizes the collaborative work of Japanese physicist Kumiko Hayashi, Tohoku University and neuroscientist Ephraim Trakhtenberg, University of Connecticut, along with Ellis Rubinstein, President and CEO, New York Academy of Sciences at the recent Interstellar Initiative workshop presented by AMED and the Academy.

International Collaboration

This teamwork is precisely what AMED president Makoto Suematsu envisioned creating through the Interstellar Initiative, part of a broader strategy to bring international partnerships and new funding streams to Japan’s R & D pipeline. As technological advances that enable data sharing and ease remote collaboration have become ubiquitous, Suematsu believes it is crucial for Japanese researchers to join global research efforts.

“International collaboration is critical in many fields,” Suematsu said. “From infectious disease outbreaks to cancer treatment and drug development, we can accomplish much more when we reach out, shake hands and collaborate.”

Cancer Research

Another Interstellar Initiative team, comprised of NYU biologist Carlos Carmona-Fontaine, oncologist Valerie Chew of Singapore Health Services and physicist Shuichi Shimma of Osaka University, is juggling large time differences and global transport of perishable patient samples as they pursue their project. Blending Chew’s expertise in oncology with Carmona-Fontaine’s efforts to understand the role of metabolites in cancer cells and Shimma’s imaging techniques, the group is uncovering the interplay of metabolite activity and immune changes in tumor cells.

Noting that the Interstellar Initiative breaks down barriers that inhibit cross-disciplinary partnerships, Carmona-Fontaine commented that scientists “usually stick to our own communities, and there’s often a disconnect between scientists from different parts of the world — yet there are many advantages to learning different ways to look at a similar problem.” Chew was thrilled to be paired with teammates who brought both new expertise and new technologies. “If you’re working in your own zone, you’ll do what’s familiar,” she said. “But bringing together different disciplines and technologies creates a novel, creative environment for solving problems.”

Realizing Applications For Their Research

Proposals devised by Interstellar Initiative teams will be submitted to international funding agencies. For physician and biologist Deepak Lamba and biologist Akira Satoh, such funding may help them realize applications for their research. Lamba, who is developing methods for using stem cells to repair retinal tissue, is working with Satoh, whose research is illuminating the regenerative pathways of amphibians. They are probing the factors that influence regenerative capabilities in mammalian and amphibious cells, with the hope of developing methods of repairing and regenerating damaged tissue.

“[Stem cell research is] moving so quickly that I think we’ll start seeing applications in the not-so-distant future,” Lamba said. Satoh noted that stem cell research is less popular among Japanese scientists, while Lamba added that few labs in the US are using amphibians to study regenerative pathways. “We would never have done this on our own — it’s a unique challenge for us to do together.”

Rubinstein is quick to highlight that this is just the beginning for the Interstellar Initiative. “This is only our first cohort, and there’s so much exciting research in the works already,” he said.

Also read: A New Approach to Studying Aging and Improving Health

The Case for Inter-Galactic Biodiversity

Astrophysicists must consider various scientific factors as they search for habitable planets. What role does inter-galactic biodiversity play? And what makes a planet biologically active?

Published April 19, 2011

By Diana Friedman
Academy Contributor

Image courtesy of Maximusdn via stock.adobe.com.

On April 12, 2011, Ben Oppenheimer, a comparative exoplanetary scientist, spoke to educators, students, and amateur astronomers at The New York Academy of Sciences (the Academy) about Inter-Galactic Biodiversity: Astrophysicists’ Search for Habitable Planets. Oppenheimer’s work often straddles the world of philosophy and science as he tackles the engineering and astrophysics of the search for habitable planets. He constantly grapples with the question “What if we actually find life on other planets?” as he engineers better ways to collect, analyze, and interpret the brightness of light as a function of wavelength, that is emitted or reflected by not too distant planets and their stars.

While Oppenheimer is an astrophysicist by training, his main area of study and the subject of his talk at the Academy offer something for teachers and students interested in the big questions of the universe—not only “Are we alone?”, but also “What does a planet with life look like?” His work and his answers to these questions traverse the historical divisions between physics, biology, and engineering.

In addition to describing the recent redefinition of planetary bodies in our solar system, he explained his use of adaptive optics (AO) to improve spectroscopy. The improvements to AO, which are technologies that decrease effects of wavefront distortion introduced when light travels through our inhomogeneous atmosphere, allow Oppenheimer a better, clearer picture of the radiating energy from planets and stars.

A Biologically Active Planet

That better picture has allowed scientists like Oppenheimer to predict what a biologically active planet would look like, specifically what chemical changes biology effects on a planet. Through improved spectroscopy, we can see that a biologically active planet will have different ratios of methane, carbon dioxide, carbon monoxide, and oxygen compared to a biologically inactive planet.

The combination of big, philosophical questions about the nature of the universe with a rich thought experiment about how life changes a planet makes Oppenheimer’s work an enticing topic for educators. His talk not only highlights a new and exciting interdisciplinary science but also clearly outlines the process by which he and other scientists combine experimental design, philosophy, and engineering to conceive, test, and refine their ideas.

Also read: The Crucial Need for Ethics in Space Exploration

Cooking for Geeks: Chemistry from the Kitchen

Do you know about the chemical and physical process that occur when cookies are baked in a toaster oven? Engineer-turned-cookbook-author Jeff Potter explores the chemistry of the kitchen in his new book.

Published November 8, 2010

By Adrienne J. Burke
Academy Contributor

Image courtesy of Pixel-Shot via stock.adobe.com.

On November 1, 2010, cookbook author, software engineer, and self-proclaimed geek Jeff Potter visited The New York Academy of Sciences (the Academy) to talk about how to teach chemistry from the kitchen. From the work of food scientists such as Harold McGee to the urban gardening movement, teachers have plenty of ways to use cooking, food, and nutrition as a theme in the classroom. Riding the wave of this interest and excitement, Potter’s talk called Cooking for Geeks: Chemistry from the Kitchen provided teachers with another way to use a hacker’s thirst for unrestricted inquiry coupled with a scientific spirit and an enthusiasm for cooking to approach inquiry and learning in their lessons.

Geeks, and Jeff wears that mantle proudly, are defined by their curiosity and desire to take things apart, see what’s under the surface, and find out how action causes reaction. Hackers, geeks in their own way, take this one step further and adapt everyday tools to carry out these investigations. For teachers, following this model means taking easy-to-find tools such as kitchen thermometers and using them to collect data about the world.

Baking Cookies…in a Toaster Oven

For example, Potter queried what could be learned from making cookies in the classroom using a toaster oven. What we find, he notes, is that for every observable change in the cookie (flattening, rising, and browning) there is a chemical or physical process that can be explored by following the temperature of the cookie. Some physical changes, such as the melting of sugar or the boiling of water are great opportunities to discuss phase changes while others, such as caramelization and the Maillard reaction, are chemical changes that can lead to lessons about atomic structures or bonding. All of these processes happen at specific temperature points or over specific ranges that can be monitored with household instruments.

Potter continued with the temperature theme by telling the audience how to “hack” a sous vide pressure cooker. While many teachers may not be interested in actually “hacking” a pressure cooker for their class, he uses the cooking technique of sous vide (a low temperature poaching method) to discuss the connection between how proteins denature with heat and how foods taste as a result of this process. To illustrate this point, he looked at why most people prefer their steak cooked medium–rare.

At this temperature some proteins, myosin molecules in particular, have denatured while actin molecules have not, and as Potter pointed out, “denatured myosin equals yummy, denatured actin equals yucky.” By cooking steak, eggs, or fish sous vide, one can control exactly at what temperature the food is cooked, and thus, what proteins get denatured.

Jeff Potter is the author of Cooking for Geeks: Real Science, Great Hacks, Good Food. His background is in computer science, and he credits cooking with saving his sanity.

Also read: Exploring the Science of Haute Cuisine

Celebrating the “The Century of Science”

Old and new friends gather to celebrate science at The New York Academy of Sciences’ Fifth Annual President’s Reception.

Published August 10, 2009

By Adrienne J. Burke
Academy Contributor

An illustration of the 7 World Trade Center building.
An illustration of the 7 World Trade Center building, home to The New York Academy of Sciences.

The New York Academy of Sciences (the Academy) prides itself on being an institution that builds bridges and establishes connections between people who might otherwise not have the chance to get together. One good example was the Fifth Annual President’s Reception in June, where scores of scientists, physicians, philanthropists, artists, entrepreneurs and others gathered to celebrate the Academy’s role in supporting science and scientists worldwide.

President Ellis Rubinstein took particular note of the mix of long-time Academy friends and new members of the Academy’s growing circle.

“When I was running a scientific conference on regenerative medicine in Beijing,” he said, “the Minister of Health of China…opened the conference by saying that the most important thing in life is the friendships that you make and the ones that you retain by the end of your life. I thought, ‘that’s an unusual thing for a scientist to say at the beginning of a scientific meeting. But it’s appropriate for this group here.”

Others addressing the audience included inventor Dean Kamen, who holds more than 440 patents on products ranging from the Segway transporter to the wearable infusion pump, and Academy Governor and Columbia University string theorist Brian Greene, the impetus behind the novel World Science Festival in New York City.

An Engaging Exploration of Science and Culture

Greene used the occasion to kick off the Festival, outlining the eclectic range of programming that has come to characterize this engaging annual exploration of science and culture. Kamen then introduced the audience to the success he’s had engaging young people in science and technology through his national robot-building contest, known as FIRST, which treats this technical challenge like a major sports competition. Teams from nearly 17,000 schools in 43 US cities participate in the FIRST program, backed by 85,000 scientists and engineers who serve as volunteer mentors.

“Kids are so distracted by what appear to be more exciting alternative career options than science, technology, inventing, and innovating, which…astounds me,” Kamen said. “Every major career opportunity they’re going to have available to them in the next 10 or 20 years is going to require a fundamental appreciation and awareness of science and technology–even if they don’t want to be a scientist or a technologist!”

NYU President and Academy Board Chair John Sexton echoed that sentiment in closing remarks.

“We have entered the century that will be defined by science,” he said. “It will be critical that we do all we can…to push the awareness of science as deeply as possible into society.” And the Academy, he added, has a unique capacity to serve that convening and catalyzing role.

“That’s why I’m committed to it,” he added. “That’s the vision of it that I hope all of you see.”

Also read: Academy’s Soiree Recognizes Excellence in Science

A New Approach to the Hippocratic Oath

For more than 40 years, public- and private-sector biochemical pharmacology experts have been sharing knowledge at Academy meetings.

Published September 1, 2007

By Jill Pope
Academy Contributor

Image courtesy of Artinun via stock.adobe.com.

It’s a rare occasion when scientists from competing pharmaceutical companies and academic laboratories come together to share their latest findings on human diseases and treatments. But since 1964, The New York Academy of Sciences (the Academy) has played host to a regular meeting of biochemists, molecular biologists, and biomedical researchers who do just that.

The members of the Biochemical Pharmacology Discussion Group (BPDG) hail from more than a dozen pharma and biotech companies, as well as top research universities and medical centers. Pfizer and Bristol-Myers Squibb provide major funding. The American Chemical Society, AstraZeneca, Boehringer Ingelheim, and Novartis also sponsor the group.

As the oldest of the Academy’s 14 discussion groups, the BPDG convenes eight times a year for half- and full-day symposia where experts address topics designated by the group’s steering committee. More than 70 scientists attend each meeting.

Good Career Move

Academy Fellow Martha Matteo began attending the group’s meetings nearly 25 years ago when she was a scientist for Boehringer Ingelheim. New to the pharma industry in 1983, she recalls she was pursuing a theory about how anti-inflammatory steroids affect protease levels. It ran counter to the conventional wisdom that “leukotrienes and prostaglandins modulate everything.”

She organized a BPDG meeting where other scientists presented evidence that steroids induce protease inhibitors. “The story was just unfolding and I got right in the thick of it,” she says. “I had the opportunity to test ideas with a broad range of industry and academic scientists, separate from long-held beliefs and prejudices.” Matteo, who eventually became director of knowledge management and R&D planning at Boehringer Ingelheim before retiring last year, adds, “The Academy has long provided neutral territory and instant feedback in the exploration of new ideas.”

For industry and academic researchers who work mostly in isolation from one another, BPDG events are opportunities to connect, says Charles Lunn, a research fellow at Schering-Plough Research Institute and the group’s current program coordinator. While attendees don’t disclose proprietary information, people do share their work. That’s essential because in industry, Lunn says, “Much high-quality science is accomplished that is never communicated to the academic community.”

From Theory to Therapy

An Alzheimer’s seminar drew more than 100 participants last December. This is another example of a BPDG forum where researchers discuss cutting-edge research. Alzheimer’s researchers have focused on two main culprits in their search for the cause of this devastating disease: amyloid-β peptide (A-beta), which forms plaques in the brain, and tau, a rogue protein that forms tangles. A-beta is produced when a large protein is cut by two enzymes. Several leading experts on one of those enzymes, γ-secretase, shared their insights into how it might be targeted by Alzheimer’s therapies. Others discussed the role of tau: some showed how amyloid pathology may trigger changes in tau, and others examined how tau abnormalities lead to cell death.

Speakers included Mark Shearman, senior director of neuroscience drug discovery research at Merck in Boston; Thomas Lanz, a scientist in central nervous system biology at Pfizer Global Research & Development; Michael Wolfe, who in 2006 established the Laboratory for Experimental Alzheimer Drugs at Harvard Medical School; and David Holtzman, head of the Department of Neurology and associate director of the Alzheimer’s Disease Research Center at Washington University in St. Louis.

Matteo, who chaired the group from 1989 to 1994, says it’s not unusual to see theories presented at BPDG meetings turn into therapies years later. Around 1990, she remembers, the group held a meeting to discuss a potential approach to cardiovascular disease called angiotensin II receptor blockers. Today, ARBs such as losartan and valsartan are standard therapy for hypertension.

Setting The Agenda, Seeking Diversity

It’s easy to imagine how the BPDG will continue to benefit young scientists’ careers the way it did Martha Matteo’s.

Recent seminars have included another on Alzheimer’s research trends—“Immunotherapy for Neurodegenerative Diseases,” in which experts discussed ways to train the body’s immune response to attack the wayward proteins that plague patients with Alzheimer’s and other diseases of the brain and spinal cord.

In May 2007, the group hosted “The Future of Monoclonal Antibody Biotherapeutics.” Monoclonal antibodies are cloned proteins that modulate the activity of specific disease targets. In cancer treatment, they zero in on tumor promoters, leaving healthy tissue alone. The therapies are already benefiting patients, but they have limitations, including high production costs. Speakers discussed new approaches, such as optimizing cell culture processes, that promise to spur the therapies forward and make them more widely available. Also this past year, speakers at BPDG’s “Novel Strategies for Compound Identification from Compound Libraries: High-Throughput Screening” presented diverse approaches to drug screening such as Biotrove’s RapidFire mass spectrometry, and virtual screening with the University of New Mexico’s high-throughput flow cytometry platform.

Diabetes to Stem Cells

The 2007-2008 meeting schedule will cover progress in treating diabetes and eating disorders, psychiatric illness, and atherosclerosis, as well as tools for drug discovery including adult stem cells and molecular imaging. Setting the year’s agenda is a labor-intensive process, requiring committee chairs to tally the votes of hundreds of discussion group members. But the result is worthwhile, says Ross Tracey, an associate research fellow at Pfizer who led the group from 2002 to 2006: “The programs that emerge have clearly passed the popularity and interest test.”

To ensure the continued relevance of BPDG meetings, Jose Perez, a senior principal scientist at Pfizer and a committee co-chair, is on a mission to recruit new members to the group. In the coming year, he’ll reach out to scientists at underrepresented pharma and biotech firms, as well as at New York City’s universities. “That’s the only way the organization is going to have a broad perspective,” he says. “We really strive for diversity of thought.”

Also read: Equivalence of Complex Drug Products: Scientific and Regulatory Challenges


About the Author

Jill Pope is a freelance science writer and frequent contributor to Academy publications.

A Scientific Perspective on the Challenges of Climate

With the threat and potential impact of climate change becoming increasingly clear, scientists and researchers are shifting their focus to try to mitigate the inevitable.

Published May 1, 2007

By Alan Dove
Academy Contributor

Climate change may be the most media-unfriendly topic scientists have ever studied. It focuses on phenomena that are so gradual and insidious that they are virtually impossible to film; its conclusions reveal the terribly disturbing truth that the comfortable standard of living to which most of the world aspires is, in fact, destroying the planet; and its celebrity spokesman is Al Gore.

How, then, does one explain the current moment?

“Who would have thought that a singer singing a song about global climate change in a movie called An Inconvenient Truth would win an Academy Award for the best song in any movie in the United States in the past year? This gives you an idea of the situation that we’ve gotten to,” says Peter Raven, director of the Missouri Botanical Garden.

On February 27, 2007, The New York Academy of Sciences (the Academy) hosted an event to honor the launch of a new scientific report on the same subject. Titled “Confronting Climate Change: Avoiding the Unmanageable, Managing the Unavoidable,” the report was written by an expert panel organized by Sigma Xi, the scientific honor society, and sponsored by the UN Foundation. The meeting at the Academy was the first opportunity for the scientific community to learn about and respond to the report, and followed a meeting between the report’s lead authors and UN Secretary General Ban Ki-Moon earlier that day.

Presenting their main conclusions to an audience of about 200 in the Academy’s main auditorium, the authors discussed the problems that have dragged climate change into the media spotlight, and proposed solutions for mitigating climate change and preparing for its inevitable effects.

Keeping Our Cool

The new report, written by an international panel of 18 scientists at the behest of the United Nations Commission on Sustainable Development, complements the series of reports now being published by the UN’s Intergovernmental Panel on Climate Change (IPCC). “It differs from the IPCC report in that we have selected between possible reactions to climate change and provided a roadmap,” says Raven, the Sigma Xi report’s lead author.

Besides being more prescriptive, the Sigma Xi report is also more blunt than most politically vetted climate change assessments. “Global climate change is real, it is primarily caused by human activities…[and] it is accelerating,” says John Holdren, director of the Woods Hole Research Institute.

Indeed, the evidence for human-driven climate change has become overwhelming in recent years. “The incidence of extreme weather events…has been going up, sea level rise has been accelerating, sea ice is melting, glaciers are retreating, permafrost is thawing, boundaries of ecosystems are moving,” says Holdren.

Researchers have linked the accelerating changes with the gigatons of carbon dioxide, methane, and other “greenhouse” gases emitted by human activities every year. By causing the atmosphere to retain more of the sun’s heat, these emissions are driving the global average surface temperature inexorably upward.

Worse, the accumulating evidence suggests that climate change may not remain gradual. Several major “tipping points,” such as the collapse of the West Antarctic ice sheet, major melting of the Greenland ice cap, desertification of the Amazon rainforest, and changes in the frequency of strong El Niño oscillations could cause sudden and catastrophic changes over the course of a few years rather than a few centuries. Climate change may be hard to sell, but it’s now also hard to ignore.

Staying within the Recommended Range

The Sigma Xi panel concluded that allowing the global average surface temperature to rise more than 2°C to 2.5°C over the next 100 years would sharply increase the risk of these catastrophic impacts. Greenhouse gases now in the atmosphere have already committed the planet to a rise of about 1.5°C.

To stay within the recommended range, the researchers assert that human greenhouse gas emissions must stabilize not much above current levels no later than 2015, then decline to no more than one third of current emissions by 2100. Compounding the problem, these reductions must occur right when the world’s poorest countries are making the transition to modernity—in other words, at the very moment when global energy demand is about to skyrocket.

Conceding that cutting emissions while raising living standards will be an immense job, Holdren is nonetheless optimistic: “It is a challenge to which we believe society can rise,” he says. In order to meet it, the panel outlined a series of recommendations, highlighting the win-win” solutions that cut energy demand while boosting economic growth.

Unfortunately, win-win solutions, such as increasing vehicle fuel economy and providing incentives for cleaning up power plants, will not be enough. The report admits that achieving long-term emissions reductions will also require “win-lose” solutions, such as a carbon tax or a “cap-and-trade” system of emissions permits.

Besides choosing the right solutions, policymakers will need to implement them properly. Picking one topical example, Holdren explains that “in the transport sector, we should be increasing the use of biofuels to replace oil, [but] we cannot do that witlessly, because expanding biofuels witlessly will pose serious problems of competition with food production…environmental destruction, [and] loss of biodiversity.”

Jousting the Four Horsemen

Food production and biodiversity were also major topics for Rosina Bierbaum, dean of environmental and natural resource policy and management at the University of Michigan. Using a pair of world maps, Bierbaum showed the group’s projections of future ecosystem upheavals and crop failures.

Even if governments follow the panel’s recommendations to mitigate climate change, some of these events are probably inevitable. “Adaptation to climate change can’t any longer be seen as sort of a cop-out; it’s not instead of mitigation, but it’s needed in addition to mitigation,” says Bierbaum.

In a generation, Mississippi may be growing coconut palms instead of loblolly pine lumber, and Vermonters’ maple syrup might come from northern Canada. More ominously, major crop failures in the tropics could cause widespread famines in Africa, South America, and Southeast Asia. Meanwhile, rising ocean temperatures and sea levels will likely increase extreme weather events and displace entire communities from coastlines. “There will be tens of millions of environmental refugees that the world will need to deal with,” says Bierbaum.

But like the mitigation measures, many of the report’s adaptation recommendations will take a concerted effort. During the question session after the presentations, for example, an audience member asked about the depressingly instructive case of New Orleans, where a multi-billion-dollar rebuilding effort is now underway on land that is infamously below sea level.

Raven concedes that the outlook is grim. “It’s a lot easier to explain the problem than to forge a solution,” he says, adding that “if we can’t really address the problem of New Orleans in an intelligent and adaptive way, and the signs are relatively few that we will, how do we get together and address the problem of Bangladesh?”

Challenges Beyond Building Codes

The challenge goes well beyond building codes. “The wetlands that are south of New Orleans have been the shock absorber for hurricanes for a very long time, and they’ve been losing for the last 50 years about 25 square miles per year,” says Michael MacCracken of the Climate Institute. MacCracken adds that “no matter what they do to New Orleans, if they don’t recover the wetlands, they’re going to get inundated [again].” The same is true for many other low-lying regions around the world.

Framing the issue more optimistically, Richard Moss, senior director of climate and energy at the UN Foundation, says that humanity still has the opportunity to choose between two futures. “The path that we’re currently on…involves increasingly serious climate change impacts,” he says. In the alternative future, however, intelligent policymaking and sustained investment in appropriate technology could help avert the climate change disaster while simultaneously boosting living standards worldwide. “We must act collectively and urgently to change our course through the leadership at all levels of society. There really is no more time for delay,” says Moss.

Also read: Climate Change and Collective Action: The Knowledge Resistance Problem


About the Author

Alan Dove is a science writer and reporter for Nature Medicine, Nature Biotechnology, and Bioscience Technology. He also teaches at the NYU School of Journalism, and blogs.