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Neuroscience and Music VII: Connecting with Music Across the Life Span

Continuing a long-running collaboration between Ann NY Acad Sci and the community of scientists in the cross-domain fields of neuroscience and music, this collection presents papers invited from participants of the 2021 Neurosciences and Music conference in Aarhus, Denmark, organized by the Mariani Foundation. Several previous collections of papers have been published in Ann NY Acad Sci, including volumes 1423, 1337, 1252, 1169, 1060, and 999. See https://nyaspubs.onlinelibrary.wiley.com/doi/toc/10.1111/(ISSN)1749-6632.neuroscience-music-vii.

Cooley’s Anemia

The papers in this virtual issue were invited from speakers of the Eleventh Cooley’s Anemia Symposium, held at The New York Academy of Sciences on October 17-20, 2022. The symposium brought together basic scientists, clinical investigators, and clinicians to review and discuss recent research for thalassemia syndromes. Several previous Annals issues have presented papers from past Cooley’s Anemia Symposia, all in collaboration with The New York Academy of Sciences. See https://nyaspubs.onlinelibrary.wiley.com/doi/toc/10.1111/(ISSN)1749-6632.cooleys-anemia.

First Winners of the Tata Transformation Prize Announced Today, Celebrating Pathbreaking Innovation in India

Three rising stars in science are recognized for their cutting-edge solutions to food security, sustainability, and healthcare.

Mumbai, India | 7 November 2023 – Tata Sons and The New York Academy of Sciences today announced the first Winners of the Tata Transformation Prize. The prize recognizes and supports visionary scientists in India who are developing innovative solutions to critical societal challenges.

Three scientists were selected from 169 entries by an international jury of renowned experts for their innovations in food security, sustainability, and healthcare. Each winner will receive INR 2 crores (approximately US$240,000) and will be honoured at a ceremony in Mumbai in December 2023. The jury included distinguished scientists, clinicians, technologists, and engineers spanning six continents from a variety of organizations, including IBM Research, Indian Institute of Science Bangalore, Indian Institute of Technology Madras, International Centre for Genetic Engineering and Biotechnology, Public Health Foundation of India, and UN-Habitat.

The 2023 Tata Transformation Prize Winners are:

A woman in pearls smiles for the camera.

Food Security Winner: Shilpi Sharma, PhD, Indian Institute of Technology Delhi
Professor Shilpi Sharma was selected by the jury for her work in the engineering of the soil microbiome using synthetic microbial communities, called microBIOme-based soil TRANSFORMation (BIOTRANSFORM). Plant diseases threaten crop productivity and, consequently, the global economy. Unlike conventional farming that uses agrochemicals and synthetic fertilizers, soil amended organically has the natural ability to suppress a wide range of plant pathogens. Starting from naturally suppressive soil, Shilpi will catalog the active microbial players and their mechanism of suppression of a range of phytopathogens. Her work will be the first to map the natural suppressive potential of soil across six states of India and to harness this potential by microbiome engineering to facilitate sustainable agriculture in the country and beyond.

Sustainability Winner: Purnananda Guptasarma, PhD, Indian Institute of Science Education and Research Mohali
Professor Purnananda Guptasarma was selected by the jury for his breakthrough methods to degrade polyethylene terephthalate (PET), a common plastic pollutant, using enzymes. PET is currently produced and used at unsustainable levels, creating worldwide plastic pollution and micro-plastic contamination in the air, water, and soil, as well as in animal and human bodies. Only 9% of PET is actually recycled worldwide. Guptasarma’s enzyme-driven strategy uses engineered thermostable enzymes and reactions to demonstrate that solid PET can be broken up into its smallest molecular building blocks with high yield and ultra-high purity to enable PET’s degradation and recycling into virgin plastic. Building on this proof of concept at the laboratory-scale, Guptasarma will further identify and improve enzymatic reagents and reactions for PET degradation and attempt to produce the best enzymes in quantities allowing pilot-scale PET-waste degradation and recycling.

A man poses for the camera.

Healthcare Winner: Anurag S. Rathore, PhD, Indian Institute of Technology Delhi
Professor Anurag S. Rathore is a healthcare pioneer aiming to reduce the manufacturing cost of biotherapeutics for treating cancer and autoimmune diseases, thus enabling equal access to these top-tier, expensive treatments currently out of reach for 90% of the Indian population. Rathore has established a state-of-the-art drug manufacturing facility with continuous processing that incorporates novel methods for real-time process monitoring and control. Rathore’s innovation is projected to reduce manufacturing costs by 50-75%, making best-in-class biotherapeutics for complex diseases significantly more affordable for Indian populations in need and further advancing India’s position at the forefront of global medical innovation.

N. Chandrasekaran, Chairman of the Board of Tata Sons, said, “We are extremely delighted to announce the first cohort of Tata Transformation Prize winners and their groundbreaking innovations aimed at solving India’s national problems in the areas of food security, sustainability, and healthcare. On behalf of Tata Sons, we are pleased to provide these scientists a global stage to take their technologies from India to the rest of the world.”

Nicholas Dirks, President and CEO of The New York Academy of Sciences, said, “Congratulations to the first Winners of the 2023 Tata Transformation Prize. From developing new soil enhancements to improve crop yield, creating methods to make critical medicines available to all, and developing techniques to tackle plastic pollution, these scientists are making important contributions to Indian society and the world. We also thank the jury for sharing their time and expertise in reviewing the submissions in the first year of the Tata Transformation Prize.”

About the Tata Transformative Prize

The Tata Transformation Prize was established in 2022 by Tata Sons and The New York Academy of Sciences to support breakthrough, innovative technologies that address India’s most significant challenges. By recognizing and supporting the implementation at scale of high-risk, high-reward research, the Prize will drive impactful innovation in scientific disciplines of importance to India’s societal needs and economic competitiveness. The Prize will leverage the exceptional potential of scientists in India to address critical national challenges in three categories—Food Security, Sustainability, and Healthcare—and generate improved life quality outcomes across India and beyond. The Tata Transformation Prize recognizes one Winner in each category, with INR 2 crores (approximately US$240,000) for each Winner. Click here for more information about the Tata Transformation Prize.

About the Tata Group

Founded by Jamsetji Tata in 1868, the Tata Group is a global enterprise, headquartered in India, comprising 30 companies across ten verticals. The group operates in more than 100 countries across six continents, with a mission ‘To improve the quality of life of the communities we serve globally, through long-term stakeholder value creation based on Leadership with Trust’.

Tata Sons is the principal investment holding company and promoter of Tata companies. Sixty-six percent of the equity share capital of Tata Sons is held by philanthropic trusts, which support education, health, livelihood generation and art and culture.

In 2022-23, the revenue of Tata companies, taken together, was $150 billion (INR 12 trillion). These companies collectively employ over 1 million people. Each Tata company or enterprise operates independently under the guidance and supervision of its own board of directors. There are 29 publicly listed Tata enterprises with a combined market capitalisation of $300 billion (INR 24 trillion) as on July 31, 2023. Companies include Tata Consultancy Services, Tata Motors, Tata Steel, Tata Chemicals, Tata Consumer Products, Titan, Tata Capital, Tata Power, Tata Communications, Indian Hotels, Tata Digital, Air India and Tata Electronics. Website: https://www.tata.com

The Tata Transformation Prize is the latest in a series of prominent awards and scholarship programs The New York Academy of Sciences and its partners present each year to accomplished early-career and established scientists worldwide. These initiatives, along with education and professional development programs for students and young scientists, reflect the Academy’s broader commitment to strengthening and diversifying the pipeline for skilled and talented scientists globally. Please visit us online at nyas.org.

Media Contact

Tata Sons
Harsha Ramachandra
harsha.r@tata.com

Evolution and Epigenetics

The 2022 symposium entitled “How Evolution Learnt to Learn – Epigenetics of Experienced Context” and this virtual issue follow on published volumes of previous symposia: Ann. N.Y. Acad. Sci. Vol. 1178 (Natural Genetic Engineering and Natural Genome Editing) in 2008, Ann. N.Y. Acad. Sci. Vol. 1341 (DNA Habitats and Its RNA Inhabitants) in 2014, and Ann. N.Y. Acad. Sci Vol. 1447 (Evolution — Genetic Novelty/Genomic Variations by RNA-Networks and Viruses) in 2018.

The symposia were organized by Guenther Witzany. The 2022 symposium included 50 experts to discuss epigenetic marking and its regulatory impact on transgenerational inheritance, cell fate and identity, morphology, physiology, genetic instructions, neuroepigenetic reprogramming, memory and learning, physical and mental disease, immunity, and the roles of persistent viruses and their co-opted and exapted defectives such as non-coding RNA networks and mobile genetic elements. The symposium took place on July 6-10, 2022 at the St. Virgil Conference Center in Salzburg.

Head administrator Hiltrud Oman managed all the details before and during the meeting; Andreas Oman, Martin Koller, and Tanja Walorz assisted directly at the conference center; and Land Salzburg and Stadt Salzburg supported the symposium. Heidi Vereno performed as the harpist at the conference dinner.

See https://nyaspubs.onlinelibrary.wiley.com/doi/toc/10.1111/(ISSN)1749-6632.evolution-and-epigenetics.

Getting Out the Facts on Public Health

A tablet with a medical application pulled up on the screen.

All-Girl Team Wins Junior Academy Challenge Combating Public Health Misinformation.

Published October 5, 2023

By Nicole Pope

Collaborating across borders, U.S.-based student Angel and Asmaa from Jordan won New York Academy of Sciences’ Junior Academy Innovation Challenge with a text-based campaign designed to combat online misinformation and provide young people with accurate facts about public health issues. The two participants were part of an all-female STEM team that also included participants from Lebanon and Oman.

Angel, aged 15, who lives in upstate New York, and Asmaa, aged 16, based in Amman, Jordan, have never met in person– but the two high school students got to know each other well over an intense 10-week period in the spring.

Both passionate about science, the teenagers collaborated online, alongside other team members from Lebanon and Oman, to compete in New York Academy of Sciences’ Junior Academy Innovation Challenge, “Combating Misinformation about Public Health.” The Junior Academy is a virtual, international network of students aged 13-17 who have a deep interest in STEM and work together to solve society’s greatest challenges (“Innovation Challenges”).

For Angel and Asmaa, the experience has been uplifting– not only because their team, “Girls Combating Misinformation,” won the challenge (chosen among 11 teams that submitted final presentations).

“Being part of this challenge has definitely impacted me, in my coursework at school, in other areas in my life. I feel better getting my voice out. I have become more of a scientific thinker overall because you have to come up with a creative solution that attracts people and offers a different approach. I feel I have grown as a person through this project,” said Angel.

Empowering Girls in STEM

Both participants acknowledge that girls sometimes lack the confidence to study science, technology, engineering and mathematics (STEM) subjects.

“Girls may think they don’t have enough knowledge to get into STEM. Sometimes, the community places the bar too high, although this may not just affect girls,” said Asmaa.

Globally, women are still under-represented in STEM-related fields, both in education and as practitioners. On average, less than 30 percent of the world’s researchers are women.[1] In general, fewer women than men study life sciences, and the gender gap is even wider in fields like engineering and maths.

Diversity is important for the future of science, which is why the Junior Academy seeks to empower young women in STEM and to encourage them to consider careers in these fields. In 2021-2022, its programs had 63 percent female participation.

At the initial stage, the teammates, coming from diverse backgrounds, assessed each other’s strengths and abilities, communicating through the Junior Academy’s Launchpad online platform.

“We all had different interests coming in, then we started narrowing them down. It was very useful to have their insights, different perspectives. It really helped the project blossom,” said Angel.

She praised the team spirit that developed among the participants as they allocated tasks and responsibilities and started developing and testing their ideas.

Developing an Idea

Before coming up with their innovative approach against misinformation, the team researched how information on vaccines, cancer, tobacco, drugs, mental health, nutrition, and other health conditions is disseminated online. They immersed themselves in their assignment, meeting online every Saturday, reaching out to experts, and carrying out surveys among their peers to gain a better understanding of the problem.

“A lot of misinformation about health affects children and teens through social media,” reflected Asmaa, who said she boosted her research skills during the challenge. “When you start researching a topic, you want to get to the root of it.”

Eventually, the students opted to use text messages as the most impactful way to reach young people, and designed a campaign that would deliver daily, accurate facts on health issues, focusing particularly on correcting misleading information on topics trending on social media. To test their approach, they encouraged peers to sign up to receive these reliable health messages.

“We were stoked to have won the challenge,” said Angel, who suggested to her teammates that they continue working on the project and implement their concept. “We’ll do some outreach and tell the world about our solution.”

Angel and Asmaa said working as a team on this assignment has taught them a lot and strengthened their skills in communication, writing, leadership and problem solving.

“I feel that all of us have gained more confidence in ourselves, and we’ll push to end the STEM gender divide,” Angel says.

Inspired to Inspire

Having a supportive mentor who shared her own expertise and provided guidance and encouragement along the way contributed to their success, Asmaa pointed out. Asmaa believes role models are important, particularly for girls who may find STEM topics daunting.

She credits a charismatic science teacher at her school for kindling her own passion for maths and biology.

“I hope one day I will be able to inspire others to do what they want. To students interested in participating in a challenge, especially girls, I would say: It is a great experience. Don’t hesitate; just go for it. We all make mistakes and we learn from them. That’s how we grow,” said Asmaa.

For teenagers who have not found such inspiration at school, she believes that participating in the Junior Academy would be an exciting way to explore STEM fields.

Asmaa says her involvement in the project has made her more self-assured, and has reinforced her desire to study medicine. Angel, whose primary interests were psychology and the human mind, says the project has sparked her interest in a new field. “After this challenge on public health, I feel I want it to be part of my future,” she said.

The Junior Academy was supported by the Stevens Initiative, which is sponsored by the U.S. Department of State, with funding provided by the U.S. Government, and is administered by the Aspen Institute.

[1] UNESCO, Women in Science 2019

A version of this story was originally published on the Stevens Initiative’s website here.

Adolescent Women Nutrition in Colombia and Vietnam

Adolescent and young women face grave nutritional challenges, but limited evidence exists on solutions to improve their diets. Supported by Fondation Botnar, Action-Research was done over three years (2020-2022) in secondary cities of Colombia (Medellin) and Vietnam (Thai Nguyen) to identify nutrient deficits in the diets of adolescent and young women; elaborate food-based recommendations to improve their nutritional status using Optifood linear programming; and engage respondents in incorporating suggested recommendations in their diet using a social innovation challenge approach. This virtual issue reports the findings of this research. See https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/nyas.15046.

Frontiers in Immunology

Technological developments such as next-generation sequencing, super-resolution imaging, and systems-level computational approaches have resulted in great leaps in our understanding of the immune system. Despite these advances, many autoimmune diseases lack effective treatments; and the current pandemic has shown the critical need to better understand the immune system in order to harness it to develop vaccines and therapeutics.

Therapeutic Promise of the Microbiome: The Dr. Paul Janssen Award Symposium

Developing targeted therapies for rare cardiomyopathies is challenging: difficulties identifying patients, delivering therapeutics, and accessing heart tissue results in a 50% mortality rate 5 years after diagnosis.  Early, accurate disease detection and classification can significantly improve outcomes for patients with rare cardiomyopathies. Achieving these goals requires multiple novel technologies to coalesce that will enable early patient identification, deepen our understanding of the disease process, improve modeling of human pathophysiology, accelerate testing of drug candidates, and leverage novel therapeutic modalities to target the heart specifically, safely and effectively.

This two-day conference will convene industry scientists, academics, and clinicians to understand the integration of artificial intelligence and engineered tissues for safe and effective delivery of novel therapeutics for patients with arrhythmogenic, hypertrophic, and dilated cardiomyopathies.

Pioneering Novel Drug Delivery Systems: The Dr. Paul Janssen Award Symposium

Since 2004, the Dr. Paul Janssen Award for Biomedical Research has honored scientists who have made a transformational contribution toward the improvement of human health. This prestigious award honors the legacy of Dr. Paul Janssen, an exceptionally gifted and passionate scientist who revolutionized modern medicine and inspired a new generation of researchers.

This half-day virtual symposium will celebrate the 2023 Honoree, Dr. Robert Langer, and his pioneering work. You can learn more about Dr. Langer below. We are proud to offer this event free of cost to anyone interested in celebrating scientific innovation. Registration is required.

Sponsors

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Artificial Intelligence & Engineered Tissues For Cardiac Disease Therapeutics

Developing targeted therapies for rare cardiomyopathies is challenging: difficulties identifying patients, delivering therapeutics, and accessing heart tissue results in a 50% mortality rate 5 years after diagnosis.  Early, accurate disease detection and classification can significantly improve outcomes for patients with rare cardiomyopathies. Achieving these goals requires multiple novel technologies to coalesce that will enable early patient identification, deepen our understanding of the disease process, improve modeling of human pathophysiology, accelerate testing of drug candidates, and leverage novel therapeutic modalities to target the heart specifically, safely and effectively.

This two-day conference will convene industry scientists, academics, and clinicians to understand the integration of artificial intelligence and engineered tissues for safe and effective delivery of novel therapeutics for patients with arrhythmogenic, hypertrophic, and dilated cardiomyopathies.